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WASHINGTON, Oct. 9 (Xinhua) -- U.S. researchers have found a way to block, in an animal model, the damaging inflammation that contributes to many disease conditions. In their report receiving early online publication Sunday in Nature Biotechnology, researchers describe using small interfering RNA technology to silence the biochemical signals that attract a particular group of inflammatory cells to areas of tissue damage."The white blood cells known as monocytes play a critical role in the early stages of the immune response," says Matthias Nahrendorf, of the Massachusetts General Hospital (MGH) Center for Systems Biology, the paper's senior author. "We now know there are two subsets of monocytes -- an inflammatory subset that defends against pathogens and a reparative subset that supports healing. But if the inflammatory response is excessive, it can block the healing process and exacerbate conditions such as heart disease and cancer."Cells damaged by injury or disease release a cocktail of chemicals called cytokines that attract immune cells to the site of the damage. Inflammatory monocytes are guided to sites of tissue injury by a receptor protein called CCR2, and the MGH-led team devised a strategy targeting that molecule to block the inflammatory process but not the action of the reparative monocytes.Small interfering RNA (siRNA) technology prevents production of specific proteins by binding to associated messenger RNA molecules and preventing their translation. However, the technique requires extreme precision in developing the right siRNA molecule and delivering it to the correct cellular location.To make sure that their siRNA preparation targeted the right monocytes, researchers first confirmed that its use reduced levels of CCR2 in monocytes and increased levels of the fragments produced when siRNA binds to its target. They then showed that monocytes from mice treated with the siRNA preparation were unable to migrate towards CCR2's usual molecular target. Experiments in animal models of several important diseases showed that the siRNA preparation reduced the amount of cardiac muscle damaged by a heart attack, reduced the size and the number of inflammatory cells in atherosclerotic plaques and in lymphomas, and improved the survival of transplanted pancreatic islets."These inflammatory monocytes are involved in almost every major disease," Nahrendorf explains. "Anti-inflammatory drugs currently on the market hit every inflammatory cell in the body, which can produce unwanted side effects. This new siRNA treatment doesn't affect inflammatory cells that don't rely on the CCR2 receptor. That makes a big difference."

BEIJING, Jan. 21 (Xinhua) -- The State Grid Corporation of China (SGCC), the country's largest electric power transmission and distribution company, said Saturday that the power supply will be sufficient during the upcoming Spring Festival holiday.Thermal power plants currently have 89.34 million tonnes of coal, which is enough for 20 days of power generation.Meanwhile, the country's electricity consumption is expected to fall by 40 percent during the holiday which lasts from Jan. 22 to Jan. 28, as many factories suspend production during the period, SGCC said.The company said it will keep a close eye on the cold weather, strengthen inspections and maintenance of high-voltage grids, and take precautions to minimize the impact of snow and freezing rain on power transmission.

WASHINGTON, Dec. 2 (Xinhua) -- The U.S. Justice Department Friday approved Google's 400 million dollar acquisition of Admeld, a company that provides an online advertising platform for publishers.The Justice Department concluded that it was "not likely to substantially lessen competition in the sale of display advertising."Google operates the largest Internet search engine in the world and one of the largest display advertising platforms. It had revenues of about 29 billion dollars in 2010, most of which came from ads revenue.Admeld, with annual revenue of 30 million dollars, offers technology services to Internet publishers that help them boost revenue by optimizing ads display from hundreds of sources.Google is expected to grab 9.3 percent of online display advertising spending in the U.S. this year, up from 8.6 percent last year, making it the No. 3 provider, according to the digital intelligence company Emarketer.The No. 1 position will be taken by Facebook with its share increased to 16 percent up from 12 percent a year ago, while Yahoo! will slip slightly to 13 percent, said Emarketer.

WELLINGTON, Oct. 17 (Xinhua) -- Parents wanting to help their children avoid asthma and other allergies are being told to give their toys a frosty reception by sticking them in the freezer.Medical scientists in New Zealand and Taiwan have discovered that freezing children's soft toys can kill almost all house dust mites (HDMs), the microscopic bugs associated with a range of allergies, including asthma.Other effective remedies for killing HDMs, commonly found in children's soft toys, were tumble drying and washing with eucalyptus oil and detergent, the scientists from New Zealand's University of Otago and Taiwan's Changhua Christian Hospital found.HDMs were strongly associated with the development of asthma in children, and the severity of asthma was in proportion to the number of house dust mites a child was exposed to when sleeping with soft toys, said a statement from the university Monday."Children frequently sleep with their favorite toys close to their airways and this may be important for HDM-sensitized asthmatic children," said University of Otago Associate Professor Rob Siebers.The scientists tested the three different cleaning methods on 36 toys divided into three groups of 12.Freezing toys for at least 16 hours at minus 15 degrees centigrade resulted in a 95-percent reduction of HDMs, as did soaking in an emulsion of eucalyptus oil and liquid detergent for one hour before rinsing and drying.Hot tumble drying for one hour reduced mites by 89 percent, the study found."Washing and soaking with eucalyptus oil and detergent is very effective in not only reducing live mites, but also reducing house dust mite allergens, compared to freezing and tumble drying," said Siebers.Ten of the 12 toys cleaned this way showed no live mites at all.Siebers said all three methods were more effective than just washing toys, because water needed to be above 55 degrees centigrade to kill HDMs, but this usually damaged the toys."My advice for parents is to either tumble dry for one hour, or freeze the soft toy overnight, and then wash it in a cold wash to remove any allergens."Siebers said the thickness of the material used in making the toys could alter the effectiveness of the three methods.The scientists would conduct further research to determine how quickly HDMs recolonized soft toys and how often toys should be treated.The study has been published in the European journal, Paediatric Allergy and Immunology.

NEW YORK, Oct. 14 (Xinhua) -- The iPhone 4S went on sale at Apple store on the Fifth Avenue of Manhattan in New York early Friday.An Apple store worker said people were waiting outside the store around 3 p.m. Thursday and underwent an overnight rain for an early purchase of the smart phone which started sale at 8 a.m. Friday.About 200 people were seen lining up outside the store and some of them said they would like to pay tribute to Steve Jobs, Apple's longtime CEO who died of pancreatic cancer at the age of 56 on Oct. 5."I'm a Steve's fan, iPhone 4S is the best of Steve's work. I am not going to buy iPhone 5,"Jim Bedford, who is in his 30s, said. "Maybe this is my last iPhone," he added.People left a Steve's picture, flowers and apples on the sidewalk to pay respect to Apple's co-founder. Some apples were seen inscribed such words as "Nice job" and "We will always remember you."Tom White, 50, said he had iPhone 1 and 3 and "now is the time to change a new one."The iPhone 4S is operated seven times faster than their predecessor and features an upgraded camera. Apple reported more than 1 million pre-orders for the iPhone 4S, breaking a mark set by last year's model. The phone also went on sale Friday in six other countries -- Britain,Germany,France,Australia, Canada and Japan.

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