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LA JOLLA, Calif. (KGTV) - Researchers at UC San Diego have developed a new way to field test for Fentanyl, a dangerous opioid that is deadly even in trace amounts.Similar to diabetes testing strips that measure glucose levels, the scientists at the Center for Wearable Sensors created a testing strip that can detect Fentanyl."You simply swipe the surface and collect the sample and analyze it in one or two minutes, on the spot," says Joseph Wang, the Center's Director.The strip uses electrochemical carbon and silver electrodes. The meter runs currents from the electrodes through the sample. Based on how the material reacts, it can tell if Fentanyl is present, down to a nanogram level.They recently published their success in an article in the Chemical and Engineering News.The practical applications of the testing strips are wide-ranging, says Wang. He believes that law enforcement, first responders, border patrol agents and post office workers would use this new technology to test any unknown substance.Recently, law enforcement agencies have been looking for ways to field-test for Fentanyl, since any contact with the drug can lead to an overdose or even death.The San Diego Sheriff's Department bought 15 TruNarc devices this past fall. Those scan materials and tell what kind of drugs are present. But they cost nearly ,000 each.RELATED: New device keeps first responders safe from dangerous drugs at crime scenesWang says his lab's testing strips can be made for pennies, and the meters needed to analyze the sample could cost less than .Addiction advocates also believe this could save lives among drug users, by giving them an easy, cheap way to test the drugs they take and make sure they're not laced with Fentanyl. Wang says his test is simpler to use than current testing strips.RELATED: Drug users can now test if Fentanyl is in the drugs they are using before injection"This could save lives," says Wang. 1943
Last year's seasonal flu vaccine effectiveness was just 42%, the US Centers for Disease Control and Prevention estimated. Even if vaccinated, then, people had inadequate protection against the flu.This limited effectiveness was due to a mutation that occurred in the influenza A (H3N2) vaccine strain, according to a new study published Monday in the journal Proceedings of the National Academy of Sciences. This vaccine mutation resulted from an egg-based manufacturing process commonly used today.This year's flu vaccine may also be imperfect, said Scott Hensley, author of the new study and an associate professor at the University of Pennsylvania. Add to that, he said, "this could end up being a pretty bad flu season."Still, he said, "our best protection" against severe illness is getting vaccinated with the flu shot we have today.Finding answersEach year before flu season begins, a vaccine is made based on whichever virus strains are expected to circulate. The selected seed strains are distributed to vaccine manufacturers which then produce their formulations and make them available to health care professionals before the season begins.During the 2015-16 season, vaccine effectiveness was 47%, while for the previous 2014-15 season, effectiveness was just 19%, according to the CDC. While the overall effectiveness of last season's vaccine was 42%, it was only 34% effective against the H3N2 viruses that dominated the season.Vaccine effectiveness varies based on how well it matches the circulating virus strains. Sometimes, a vaccine corresponds to the predominant virus yet its effectiveness is still not what scientists would expect. Trying to understand which element of the vaccine failed is difficult.Hensley and his team began their investigation of last year's vaccine by looking at the seed strains that had been distributed to vaccine manufacturers. These seed strains had been propagated in chicken eggs, the common method used today."The sequences of these viruses are available and when we did an alignment to see what the sequence of these vaccines were compared to the viruses that were circulating, it became very obvious that there was this mutation," said Hensley.To see the effects of the mutation, the team next looked at how the immune systems of both animals and humans who'd been inoculated with an egg-based flu vaccine responded to the actual circulating viruses.The antibodies -- immune system proteins that fight invading pathogens -- elicited in both animals and humans failed to bind to and neutralize the flu viruses, Hensley and his colleagues found.While most vaccines in the United States are made in chicken eggs, a small fraction are produced in insects or mammalian cells, Hensley explained. (These are given to people with egg allergies.) He and his team compared immune responses in animals and humans who had received a cell-based vaccine -- in this case, Flublok made by Protein Sciences Corporation."And we found both animals and humans receiving that (cell-based) vaccine had superior antibody responses that could bind and neutralize these circulating H3N2 strains," said Hensley.Making a better vaccine"Most of the infrastructure to produce vaccines in the US is based on chicken eggs," said Hensley. There are good reasons for this, including the fact that egg-based propagation allows manufacturers to quickly produce large quantities of vaccine.While egg adaptations have always been a problem, beginning last year it had become a "huge problem," said Hensley. "As soon as you try to grow this virus in eggs, within a few hours, the virus will acquire this kind of mutation."This is not an easy problem to fix, he said. To produce vaccines in cells means "a very expensive process for companies to just change their overall manufacturing process," Hensley explained. "You can't really do that on the drop of a dime."Meanwhile, the same seed strains used last year are being used this year to make the current vaccine, said Hensley."This year may be especially difficult because, in addition to this egg adaptive mutation which was present last year, there's indication that the H3N2 viruses are actually evolving," said Hensley.Not only will the vaccine be a mismatch with the actual circulating viruses due to egg adaptation but the vaccine could also be a mismatch due to unexpected viral evolution.What kind of flu season is ahead?It's too early to speculate which viruses will become dominant in the United States over the course of the coming flu season, said Hensley, "but it's starting to look like it will be H3 viruses." H3 viruses are influenza A viruses."There are the A group of viruses and the B groups," said Dr. William Schaffner, an infectious disease specialist at Vanderbilt University. "The A groups are the ones that usually are responsible for large epidemics ... whereas the B flu strains usually smolder along. They always cause illness -- it can be just as severe as the A strains -- but they don't produce large outbreaks."Though last year's vaccine was mostly ineffective in thwarting the flu, it still prevented nearly 30% of hospitalizations that might have resulted, according to CDC calculations. For older adults, that rate was even higher, at 37%. Plus, the vaccine reduced outpatient visits by 42% last season.The CDC advises everyone 6 months and older to get a flu shot, as only injectable flu vaccines are recommended. More than 130 million doses of flu vaccine have been distributed so far this year and flu activity is still low across the nation.It's still early days, but experts believe we may be facing a tough season, and not only because of vaccine concerns.The reason?Australia had a tough flu season this year, with a total of 215,280 laboratory-confirmed cases and 504 flu-associated deaths reported to its National Notifiable Diseases Surveillance System as of October 13, government data show. According to a surveillance system report, adults over the age of 80 and children between 5 and 9 years old have been most affected."In general, we get in our season what the Southern Hemisphere got in the season immediately preceding us," Dr. Anthony Fauci, director of the United States' National Institute of Allergy and Infectious Diseases, said in an interview last month.An "intelligent guess," therefore, is that the Northern Hemisphere, like the Southern Hemisphere, will likely battle more cases of the viral infection, he said, though "with influenza, it is never 100%.""If H3N2 viruses dominate the US flu season again this year, vaccine effectiveness will likely be moderate to low again," said Hensley.Still, he said, everyone should get their annual flu shot."The other components of the vaccine, like H1N1 and influenza B, will likely provide excellent protection," said Hensley. "The vaccine will also likely prevent severe disease and death caused by H3N2 viruses, even though this component of the vaccine is mismatched." 6969
LAS VEGAS — Big lavish weddings aren’t in style right now. That’s because the global pandemic has couples rethinking their plans.A new Las Vegas business is offering a unique way to scale back wedding ceremonies in light of COVID-19.I Do Drive Thru Weddings is an Australian-based company that’s branching out in Las Vegas. They host elopements and tiny weddings.Couples can choose their own adventure — they can ump into a limo, vintage vehicle, or anything on wheels and head to a special spot to say “I do.” Couples can also walk to their destination if they prefer.“This is how I Do Drive Thru came to be as we realized getting married is still absolutely an essential business,” said Berlynn Holdmann, the lead officiant in Las Vegas. “It can be done within the limitations and guidelines that are being enforced with social distancing measures.”Couples can skip the cost of a venue, DJ, and catering costs. The average wedding costs come out to 0, Holdmann said.There’s an option to livestream the ceremony, so loved ones can be a part of the celebration from a distance.I Do Drive Thru’s website says they will offer a full refund in the event of a total lockdown.This story was originally published by Kelsey McFarland on KTNV in Las Vegas. 1259
Latest update Friday, November 13: The Associated Press projects President Donald Trump will win North Carolina and take their 15 electoral college votes. Trump leads in North Carolina by 73,697 votes. Friday was the deadline for counties to certify their election results. Trump now has 232 electoral college votes and Joe Biden is still at 290. The AP has already projected Biden will win the presidential election. Meanwhile, Georgia remains uncalled at this time. The Associated Press has not projected a winner in that state and the margin between the two candidates remains at 0.3 percent in Biden's favor. A hand recount audit is underway currently. UPDATE 12:30 p.m. ET Tuesday, November 11: The Associated Press projects President Donald Trump will win Alaska, and take their 3 electoral college votes. This brings Trump up to 217 electoral votes and Joe Biden is still at 290. The AP projected Biden will win the presidential election.A recount in the presidential race will happen in Georgia, and North Carolina has still not been called for either candidate at this time. UPDATE Saturday 7 p.m. ET: The presidential race has still not been called in Georgia and North Carolina at this time. Trump leads in North Carolina by around 75,000 votes and Biden has a small lead in Georgia. Democrats will maintain majority in the House of Representatives. In the Senate, Democrats have 48 seats and Republicans have 48 seats, there are two senate races in Georgia headed to a run-off election in January.UPDATE Saturday 11:30 a.m. ET: The Associated Press is projecting Joe Biden will be elected President of the United States, after being projected to win Pennsylvania and Nevada Saturday morning. 1712
LAKE CHARLES, La. — Wrapping gifts during the holidays is a highlight for Stacy Williams, as she does it even for friends and family who ask her to do theirs. This year, though, the normally happy task masks a sad year.“There's no tree. There’s no decorations,” she said. “It's just not something that I'm used to because Christmas is my favorite time of year.”Williams and her family evacuated their rental home in southwest Louisiana just before Hurricane Laura in August.“Then in the midst of everything, between Laura and also [Hurricane] Delta, we lost my mom,” she said.It is a deep loss Williams is still trying to come to terms with, as she faces a potential new loss: eviction from her home.“So many people are going through it and it's just like, ‘what are we supposed to do?’” Williams said.It’s not hard to find damage around Lake Charles, but it is hard to find suitable housing for those who have been displaced, months after Hurricanes Laura and Delta tore through there.“It's been a very dynamic and ever-evolving situation,” said Stephanie Wagner with the American Red Cross of Louisiana.The Red Cross is working to help Williams and others find a new place to live because hurricanes impacted their work and living situations.“For the financial assistance that is provided, that is one of the uses that residents can use it for,” Wagner said. “It can be used for a down payment. It can be used to kind of supplement what they may need for any kind of rental assistance and we are partnering with other agencies including FEMA, to again find either temporary housing or more long-term and sustainable housing for these individuals.”However, for others not impacted by natural disasters across the country, help is far more limited and the potential for evictions far more widespread.According to the Census Bureau, one-third of all the households in the country are behind on their rent or mortgage.Aside from the District of Columbia, the states with the highest percentage of people facing eviction are South Dakota, followed by North Carolina, Georgia, Oregon, New Mexico, Wyoming, Ohio, Arizona and Louisiana.For now, Williams is just trying to stay positive and keep it all in perspective.“As much as you want to give up, don't,” she said. “Because even in the midst of all of this, I'm still going to hold onto faith and hope that ‘a way’ will be made out of ‘no way.’”The current COVID-19 relief bill that Congress has been working on would potentially extend the moratorium on evictions through February. As of now, that moratorium expires on January 1. 2586