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With a mask covering his face and his fingers playing a disinfected piano, musician Purnell Steen and his band, Le Jazz Machine, are back to doing what they love: playing music in front of a live audience, but now from a regulated distance.“It is a new learning experience for all us,” Steen said.After being shut down for months due to coronavirus concerns, Steen is back on his home stage at Dazzle in downtown Denver, one of the top 100 jazz bars in the world.“For the entire month of June, we did as much as much revenue as we used to do on a good Saturday,” said Matt Ruff, Dazzle general manager.Ruff says new safety guidelines that allow live music venues like his to operate are impacting his bottom line.“Capacity went from 50 to 100 people,” he said. “But it’s still 6-foot distancing between tables and the closest table to the stage has to be 25 feet away from the stage.”Though he’s thankful to reopen, Ruff is also questioning some of those safety measures, like no longer allowing wind instruments to be played on stage.“I think that’s based on faulty information,” he said. "People think that horns project something, but the science is just not there.”Some scientists, however, believe those brass instruments could hit a sour note when it comes to health.“You’re blowing from the lungs, so they are respiratory droplets and that’s the primary means by which this virus is transmitted,” said Sheryl Zajdowicz, Ph.D., a biology professor at Metropolitan State University of Denver.This infectious disease specialist says while live music could be good for the soul, social distancing could be even better for one’s health.“When you’re at a music venue, you’re kind of up against each other,” she said. “It’s going to be very challenging to limit that from happening.”That’s where Live Nation comes in.This entertainment group is now promoting “Live from the Drive-In,” a new live music experience where people can watch and listen to top artists from their own individual tailgate zones at outdoor concerts across the country.Back at Dazzle, fans say live music is what they need during this pandemic.And while the new normal on stage could be confining for artists, they believe live music will help calm emotions as the virus moves towards a crescendo.“If we can bring a few moments of joy to somebody than we have performed our mission,” Steen said. 2376

With a coronavirus vaccine still months off, companies are rushing to test what may be the next best thing: drugs that deliver antibodies to fight the virus right away, without having to train the immune system to make them.Antibodies are proteins the body makes when an infection occurs; they attach to a virus and help it be eliminated. Vaccines work by tricking the body into thinking there’s an infection so it makes antibodies and remembers how to do that if the real bug turns up.But it can take a month or two after vaccination or infection for the most effective antibodies to form. The experimental drugs shortcut that process by giving concentrated versions of specific ones that worked best against the coronavirus in lab and animal tests.“A vaccine takes time to work, to force the development of antibodies. But when you give an antibody, you get immediate protection,” said University of North Carolina virologist Dr. Myron Cohen. “If we can generate them in large concentrations, in big vats in an antibody factory ... we can kind of bypass the immune system.”These drugs are believed to last for a month or more and could give quick, temporary immunity to people at high risk of infection, such as health workers and housemates of someone with COVID-19. If they proved effective and if a vaccine doesn’t materialize or protect as hoped, the drugs might eventually be considered for wider use, perhaps for teachers or other groups.They’re also being tested as treatments, to help the immune system and prevent severe symptoms or death.“The hope there is to target people who are in the first week of their illness and that we can treat them with the antibody and prevent them from getting sick,” said Dr. Marshall Lyon, an infectious disease specialist helping to test one such drug at Emory University in Atlanta.Having such a tool “would be a really momentous thing in our fight against COVID,” Cohen said.Vaccines are seen as a key to controlling the virus, which has been confirmed to have infected more than 20 million people worldwide and killed more than 738,000. Several companies are racing to develop vaccines, but the results of the large final tests needed to evaluate them are months away.The antibody drugs are “very promising” and, in contrast, could be available “fairly soon,” said Dr. Janet Woodcock, a U.S. Food and Drug Administration official who is leading government efforts to speed COVID-19 therapies. Key studies are underway and some answers should come by early fall.One company, Eli Lilly, has already started manufacturing its antibody drug, betting that studies now underway will give positive results.“Our goal is to get something out as soon as possible” and to have hundreds of thousands of doses ready by fall, said Lilly’s chief scientific officer, Dr. Daniel Skovronsky.Another company that developed an antibody drug cocktail against Ebola — Regeneron Pharmaceuticals Inc. — now is testing one for coronavirus.“The success with our Ebola program gives us some confidence that we can potentially do this again,” said Christos Kyratsous, a Regeneron microbiologist who helped lead that work.Regeneron’s drug uses two antibodies to enhance chances the drug will work even if the virus evolves to evade action by one.Lilly is testing two different, single-antibody drugs — one with the Canadian company AbCellera and another with a Chinese company, Junshi Biosciences. In July, Junshi said no safety concerns emerged in 40 healthy people who tried it and that larger studies were getting underway.Others working on antibody drugs include Amgen and Adaptive Biotechnologies. The Singapore biotech company Tychan Pte Ltd. also is testing an antibody drug and has similar products in development for Zika virus and yellow fever.“I’m cautiously optimistic” about the drugs, said the nation’s top infectious diseases expert, Dr. Anthony Fauci. “I’m heartened by the experience that we had with Ebola,” where the drugs proved effective.What could go wrong?— The antibodies may not reach all of the places in the body where they need to act, such as deep in the lungs. All the antibody drugs are given through an IV and must make their way through the bloodstream to wherever they’re needed.— The virus might mutate to avoid the antibody — the reason Regeneron is testing a two-antibody combo that binds to the virus in different places to help prevent its escape.Skovronsky said Lilly stuck with one antibody because manufacturing capacity would essentially be cut in half to make two, and “you will have less doses available.” If a single antibody works, “we can treat twice as many people,” he said.— The antibodies might not last long enough. If they fade within a month, it’s still OK for treatment since COVID-19 illness usually resolves in that time. But for prevention, it may not be practical to give infusions more often than every month or two.A San Francisco company, Vir Biotechnology Inc., says it has engineered antibodies to last longer than they usually do to avoid this problem. GlaxoSmithKline has invested 0 million in Vir to test them.Giving a higher dose also may help. If half of antibodies disappear after a month, “if you give twice as much, you will have two months’ protection,” Lilly’s Skovronsky said.— The big fear: Antibodies may do the opposite of what’s hoped and actually enhance the virus’s ability to get into cells or stimulate the immune system in a way that makes people sicker. It’s a theoretical concern that hasn’t been seen in testing so far, but large, definitive experiments are needed to prove safety.“As best as we can tell, the antibodies are helpful,” Lyon said.___Marilynn Marchione can be followed on Twitter: @MMarchioneAP___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 5919

WINNIPEG, Manitoba (AP) — Canadian fashion mogul Peter Nygard has been arrested in Winnipeg. Court records show Nygard, 79, was arrested under the Extradition Act and is set to appear in a Winnipeg courtroom this afternoon.According to the U.S. Attorney’s Office for the Southern District of New York, Nygard faces a nine-count indictment in the United States on racketeering, sex trafficking, and related crimes.Manhattan federal prosecutors stated Nygard’s charges relate to a “decades-long pattern of criminal conduct involving at least dozens of victims in the United States, the Bahamas, and Canada, among other locations.”Earlier this year, U.S. federal authorities raided the Manhattan headquarters of the Canadian fashion mogul in February. This search came amid claims he trafficked and sexually assaulted dozens of teenage girls and women.The FBI searched the designer’s Times Square offices less than two weeks after 10 women filed a lawsuit accusing Nygard of enticing young and impoverished women to his estate in the Bahamas with cash and promises of modeling opportunities.According to prosecutors, from 1995 to 2020, Nygard used his international fashion brand to recruit and pay for sex with the victims, who were put on the payroll as “models” or “assistants.”Prosecutors said Nygard allegedly referred to the victims as his “girlfriends,” which required them to travel and stay with him at his palatial properties in California, the Bahamas, and Canada.According to the press release, Nygard allegedly hosted so-called “Pamper Parties,” named for their buffet, open bar, and spa treatments, to recruit more girls and young women.According to prosecutors, he allegedly would use a “girlfriend” or employee to scout out a chosen victim — who would then be forced into sexual activity and paid in cash.Prosecutors said Nygard also is accused of hosting sexual “swaps” with other friends and business associates, who would bring a “date” to trade for sex with one of his “girlfriends.”Nygard kept the “girlfriends” under constant surveillance, insisting they needed his permission to leave the properties, prosecutors said.According to the AP, several of Nygard’s victims claim they were 14 or 15 years old when the fashion mogul gave them alcohol or drugs and then raped them. 2300

While kids are on summer break, districts across the country are working to determine whether or not to reopen schools, and how to do it safely.School leaders are racing the clock to figure out what the next school year will look like.“We’ve been looking at how can we provide a high quality education in this environment,” said Lisa Yates, Superintendent at Buena Vista School District.For Yates, that decision is simple.“We’re hearing that from families, we’re hearing that from students, we want to be back in school,” she said.At Buena Vista Middle and High School in the Colorado mountains, summer school is in session at their brand new, still under construction, building. Students and teachers are piloting a new platform that leaders hope will help come fall.The platform was installed in early June and created by tech company Wolk. It works like this -- first, gateways are installed in classroom ceilings.“The system is called Open,” said Rene Otto, Solutions Architect for Wolk.com.Next, students and teachers put on a wearable device at the beginning of the school day. “They’re given these safety cards or wristbands, so what these do is they act as beacons,” she explained.The devices currently use Bluetooth to communicate. Using the gateways, the software shows when a beacon comes within a certain amount of space of another beacon, for how long, and if the beacon moves rooms.“The point of it was to help people understand where they are in a physical space, so we can figure out if safe social distancing is being practiced,” Otto said.The school district’s technology coordinator, Matt Brooker, helped install the system. “If we did have an incident where a kid is positive, could we do contact tracing with this?” he said.For students, the idea seems simple enough.“It’s going to record where you walk and how close you get to other people,” 6th grade Aidan explained. “It’s like wearing a little necklace. It doesn’t really bother me that much.” Others weren’t as convinced. “Personally, I don’t know if a lot of people are going to want to wear them,” 10th grader Taylor said.With every tracking device comes concerns over data and privacy.“It took me a little bit,” said Reba Jackson, a teacher at the school. “I’m a little paranoid about tracking things.”“I went from feeling like it might be a little bit invasive,” teacher Robin Fritsch, explained. “It’s not a big deal. If it gives us valuable data, I’m in.”Otto said not to worry.“We really want to make sure privacy is protected. So the way it works is, only the administrators of the schools have access to the identifying information,” she explained. In other words, each tracker has a number as the identifying name. Only school admin members are able to match that number with a student. “I don’t think any parents or people want to be tracked by a technology company generally. But if that information can help make people safer, I think it’s valuable.”Otto said for the system to work fully, they need at least 60% of students and teachers using it. This helps find hot spots that potentially need more cleaning or more attention to create a better socially distanced space.“I think it’s going to be a valuable tool,” Fritsch said.As students come back, the hope is that the system will help identify who has come into contact with someone who tested positive for COVID-19, and stop the spread there. This could mean the difference between sending 10 kids home and sending the entire school home in the event of a positive case.“Typically rural communities, as far as economic development, don’t have the resources the major metropolitan areas might have,” said Wendell Pryor, Director of Chaffee County Economic Development Corporation. “So any tool like this that aids in the threat of an outbreak and the way it might spread, I think is going to be a bonus to everybody involved.”“In person is where we want to be, so we’re putting our resources there,” Superintendent Yates said. 3979

With NFL preseason games scheduled to be held next month, several outlets are reporting that the NFL will reduce the number of preseason games teams play from four to two.Pro Football Talk and ESPN reported the change Wednesday afternoon, but the league has not made an official announcement.Pro Football Talk said that the league decided to eliminate Week Nos. 1 and 4 of the preseason. The report says that in addition to teams not wanting to travel large numbers of personnel amid a pandemic, with a lack of offseason workouts, coaches indicated a preference to hold extra practices instead of preparing for exhibitions.The length of the preseason has been considered too long by some in the past, as most teams opt to play reserves for the fourth and final game of the preseason. But the loss of a preseason home game could result in a decrease in revenue for teams.It remains unclear if teams will be allowed to welcome fans in stadiums this fall. 960