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Things are sizzling in the back of this food truck as burgers are served with a side of bravado.Mike Schuster and Dominic Maldonado have been in the food truck game for almost seven years, and in that time the industry has boomed.“When we first hit the road, I think there were maybe 230 licensed food trucks in all of Denver. I think now it’s over 500,” said Schuster.Doubled in Denver and nearly doubled across the US.According to the US Census, in 2013 there were almost 3,300 food trucks in the US. That number grew to just under 6,000 in 2018. Sales have risen from 0 million in 2012 to .2 billion in 2017.“We’ve seen it, we’ve seen it in front of office buildings, we see it in the downtown core. And I’m not just talking because of COVID, I’m talking a natural business marker, alive and well within the hospitality and restaurant industry,” said Steve Chucri, the president of the Arizona Restaurant Association He says food trucks are here to stay in his state as well.“I think they’ll always have their place and their spot in the industry," Chucri said.A unique opportunity that food trucks have, they are a to-go business and most social distance guidelines during the pandemic don’t hold them back in the same way they do sit down restaurants.But that doesn’t mean the industry is not facing its own challenges.“Back when April hit and everything shut down, it was about a month and a half straight for us of just wedding cancelations, graduation party cancelations, party after party everyday,” Schuster said.“Food trucks depending on those office buildings to have people pouring out at 12 noon everyday and going to a food truck and buying. So, they’ve got to be hurting just like all of us are,” said Chucri.But with challenges come opportunity so Maldonado and Schuster got to work and got creative.“We started going after some of the business to serve some of the front line workers during the pandemic so we started serving some of the workers at King Soopers who were working their butts off through the whole thing. We fed some the Aurora 911 services, the ambulance services because they were working their butts off. We started doing hospital servings. We found a way to find where people were hungry, working still, needed to eat, and just didn’t have a lot of viable options,” said Schuster.Getting creative to get by. Just like a lot of us over the last several months.One thing that doesn’t change, wherever Maldonado and Schuster serve food, they serve it with heart.“When people come back to the truck for seconds and thirds, because they just want to try every flavor of slider we have, even when they’re stuffed. Even just that, even when they don’t even say anything, you know that they love it and they see the smile on their face and it’s great,” said Schuster. 2809

There’s been talk of a “blue wave” heading into the midterm elections, with more Democrats energized and ready to vote. But just two weeks before the midterms, a new poll suggests the wave could be crashing.The lead in the election polls Democrats once had has fallen. In many of the battleground House or Representatives races, candidates from both parties are running almost even, according to a Washington Post poll.Another report finds Republicans are outpacing Democrats in early voting in key states, many of which are seeing record turnout.President Donald Trump outlined what he feels has sparked the turnaround.“This will be the election of the caravan, Kavanaugh, law and order, tax cuts and common sense,” Trump says.Even Democrats are downplaying the chances of a “blue wave.”“If the election were held today, the Democrats would handily win the House,” Nancy Pelosi, Minority Leader of the United States House of Representatives, says. “I can only speak in the present tense because you never know in a couple of weeks.”The president just announced he'll hold at least another ten rallies before the midterms, meaning he will have spoken at more than 30 rallies in the final five weeks of the campaign.President Barack Obama is also on the road, campaigning for Democrats.“The consequences of anybody here not turning out and doing everything you can to get your friends neighbor's family to turn out, the consequences of you staying home would be profoundly dangerous to this country and to our democracy,” Obama said during a recent rally.In these final couple weeks, both parties are having rallies across the country to motivate their base and to see which party can convince more of their voters to turnout. 1733

Too few new antibiotics are under development to combat the threat of multidrug-resistant infections, according to a new World Health Organization report published Tuesday. Adding to the concern: It is likely that the speed of increasing resistance will outpace the slow drug development process.As of May, a total of 51 antibiotics and 11 biologicals -- medical products often made from natural sources -- are being developed, the new report said."The idea is that biologicals could replace use of antibiotics, which could help in overcoming the resistance problem," Peter Beyer, an author of the report and senior adviser to the WHO's Department of Essential Medicines and Health Products, wrote in an email.Seemingly, this large number of potential new drugs should suffice, yet it is not nearly enough.First, just 33 of the antibiotics in the pipeline target priority pathogens. This year, the WHO published a list of a dozen "priority pathogens": 12 separate families of antibiotic-resistant bacteria that pose the greatest threat to human health.Among the priority pathogens is a drug-resistant tuberculosis, which kills about 250,000 people around the world each year, and a variety of multidrug resistant strains -- Acinetobacter, Pseudomonas and various Enterobacteriaceae -- which are responsible for infections in hospitals and nursing homes and among patients whose care requires ventilators and catheters.Of the 33 potential medicines for treating priority bug infections, only eight are innovative treatments. The other 25 are simple modifications of existing families of antibiotics. At best, then, the 25 will serve as short-term solutions since it is expected bacteria will quickly adapt to and resist these new (though somewhat familiar) drugs, according to the WHO."It is difficult to speculate why companies develop specific new medicines," Beyer noted. "But in general many new treatments do not necessarily constitute advances over existing treatments."TB infections require a combination of at least three antibiotics, according to the new report, yet only seven of the new TB medicines are even in clinical trials. Soon, there will be a serious lack of treatment options for this infection, the report warns.The same is true for gram-negative pathogens, which can cause severe, often deadly infections typically in hospitals and nursing homes.Gram-negative bacteria have more complex cell walls than gram-positive, explained Beyer. "In a nutshell, it is more complex to develop a novel antibiotic that can penetrate the complex gram-negative cell wall and stay inside the bacterium," he wrote.Finally, the WHO sees too few oral antibiotics being developed. These are necessary "to target the critical priority pathogens (and) be accessible in low- and middle-income countries," Beyer noted.To address the problem of developing new antibiotics, the WHO and the Drugs for Neglected Diseases Initiative set up the Global Antibiotic Research and Development Partnership. However, new drugs alone cannot combat the threat of antimicrobial resistance. The WHO is also working to improve infection prevention and control while developing guidance for the responsible use of antibiotics."Always seek medical advice before taking antibiotics and then always follow the advice of the health-care professional," Beyer noted.The new report is a "fantastic (and very useful!) summary" of the antibiotic situation, wrote Bill Hanage, an associate professor of epidemiology at Harvard T.H. Chan School of Public Health, in an email. Hanage, who has also published studies of antibiotic resistance, was not involved in the new report.Although the risk of getting a completely resistant infection is low in the United States, about 2 million people each year become infected with "resistant enough" bacteria that are harder to treat, Hanage said. And every year, more than 20,000 people die of these infections."More resistant infections don't just mean you or someone you care about is more likely to die from one, they also mean healthcare will get even more expensive," Hanage said. "Many of the procedures we take for granted in medicine, from cancer treatments to surgeries, depend on our ability to handle infections that happen in the course of treatment."The number of new drugs in development is simply not enough, he said."The great majority will not make it into the hands of doctors or your treatment," Hanage wrote. "As the report states, for drugs to be used in humans they have to pass 3 hurdles, the phase 1, 2 and 3 trials. Drugs entering that pipeline have just a 14% chance of getting all the way through to be used in humans." 4676

There were more than 35,600 requests from 28,200 public school teachers in every state on the crowdfunding website DonorsChoose.org — until now.The website that allows folks to seek donations to fund projects announced a company called Ripple, a global network that supports digital money transactions, donated million to fund every classroom project request on the crowdfunding platform.The gift represents the largest donation received by DonorsChoose.org in its 18-year history, according to a news release. "Ripple and its executives contributed the donation in XRP, which was converted to U.S. dollars and used to purchase the classroom materials," the release said."The Ripple team's donation provides the ultimate culmination of #BestSchoolDay, a campaign launched in March 2016 when 58 athletes, artists, entrepreneurs and philanthropists funded classroom requests in cities and states covering just under half of the country," the release said. "For a limited time, as teachers generate new classroom project requests on the site, DonorsChoose.org will offer donors the option of giving to the #BestSchoolDay Fund, which will be used to support projects from teachers creating their first requests on the site."DonorsChoose.org estimates that teachers will submit at least another 135,000 classroom project requests between now and the start of the next school year," the release states.  1434

Top Republicans on Capitol Hill have made a concerted decision in their Russia inquiries: They are staying away from digging into the finances of President Donald Trump and his family.Six Republican leaders of key committees told CNN they see little reason to pursue those lines of inquiry or made no commitments to do so -- even as Democrats say determining whether there was a financial link between Trump, his family, his business and Russians is essential to understanding whether there was any collusion in the 2016 elections.Republicans have resisted calls to issue subpoenas for bank records, seeking Trump's tax returns or sending letters to witnesses to determine whether there were any Trump financial links to Russian actors -- calling the push nothing more than a Democratic fishing expedition.  820