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SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789

SAN DIEGO (CNS) - A man accused of carrying out a series of credit union heists in San Diego County, stealing more than ,000 over a three-month span, pleaded not guilty Friday to 10 felony counts, including robbery and attempted robbery.Karl Doron, 43, was arrested Tuesday after he entered the Navy Federal Credit Union, 6755 Mira Mesa Blvd., and allegedly demanded cash from the employees, according to FBI Special Agent Davene Butler.Police officers and FBI agents had been monitoring Doron based on information they had gathered in an investigation that began in late December, when the first robbery occurred, Butler said.Upon leaving the credit union, he was taken into custody without incident and found to be carrying a loaded handgun, the agent said.RELATED: FBI searching for 'Gloved Robber' in series of credit union heistsDeputy District Attorney Andy Aguilar said Doron, whose alleged spree started three days after Christmas, used gloves, glasses, coats and other clothing to mask his identity. He would pass notes to the tellers asking for cash, and was successful on all but two occasions, the prosecutor alleged.Investigators have recovered ,000 Doron allegedly took in his last heist, but ,500 remains outstanding, he said.The defendant faces 14 years and four months in prison if convicted of all counts.Doron's attorney, Deanna L. Lopas, emphasized that none of the holdups her client is alleged to have committed involved violence or threats, simply the passing of a note.She also noted that he has no prior criminal record and holds a doctorate in neuroscience. Doron's LinkedIn page indicates he received his degree from the University of California, Santa Barbara in 2011 and previously served as an Infantry Squad leader in the Marine Corps. His last entry on the LinkedIn page is for work as a postdoctoral scholar at UC San Diego, which ended in January 2015 and involved conducting ``realtime brain-machine interface experiments using electroencephalography.''Doron is being held at San Diego Central Jail in lieu of million bail and is due back in court March 27 for a readiness conference. 2137

SAN DIEGO (CNS) - Backers of an initiative that would have raised San Diego's hotel tax to fund a long-awaited expansion to the city's bayfront convention center failed to collect enough valid signatures to earn a spot on the November ballot, the city clerk's office announced Wednesday.A random sampling of the campaign's more than 114,000 signatures by the county Registrar of Voters fell short of the threshold of verified signatures needed to place an issue on the ballot. A signature-by-signature count will start immediately, but such a count typically takes 30 days to complete, and the deadline to place a measure on the ballot is Friday."Colossal failure," initiative opponent City Councilman David Alvarez wrote on his Twitter page.Overall, 71,646 valid signatures are needed to place an initiative on the ballot. The signature-by-signature count could qualify the hotel tax increase for a future election if it isn't completed in time for the November ballot.The City Council could also decide to place the measure on the ballot during a Thursday special meeting, but that would raise the initiative's required success threshold to two-thirds voter approval.The proposed initiative would raise the city's 12.5 percent hotel tax to 13.75 to 15.75 percent depending on the location of each hotel.The 42-year tax increase was expected to generate .4 billion, including nearly .8 billion for the convention center.An estimated 7 million would have gone to homelessness services and housing funding over the tax increase's first five years. An additional 4 million would have gone to road repairs. 1621

SAN DIEGO (CNS) -- A San Diego man who allegedly had Molotov cocktails in his possession at last month's La Mesa police brutality protest is facing federal charges, the U.S. Attorney's Office announced Tuesday.Zachary Alexander Karas, 28, is charged with possession of an unregistered destructive device for allegedly having two glass bottles containing gasoline and wicks while at the protest, which began May 30 and carried over into the morning of May 31.According to the charging document, officers spotted Karas and his girlfriend sitting on the pavement at the corner of Allison Avenue and Spring Street at around 2 a.m. May 31.Karas was arrested for not leaving the area after dispersal orders were given by law enforcement, following the declaration of an unlawful assembly, according to the complaint.In an interview with law enforcement, Karas allegedly said "he brought the Molotov cocktails to the protest at the police station because he intended to use the Molotov cocktails to set fires, but ultimately did not cause any fires."Fires were set at the Chase and Union Bank branches and Randall Lamb Associates building near the site of the protest, but the complaint does not allege Karas set any of the fires sparked following the protest."The Constitution strongly protects the First Amendment right of all to speak out and peacefully protest," said U.S. Attorney Robert Brewer. "My office is committed to protecting that First Amendment right."Violence, however, by a relatively small number of opportunists who sought to wreak havoc, destroy property, and threaten the safety of peaceful protesters will not be tolerated." 1647

SAN DIEGO (CNS) - Flagship Cruises and Events has announced its San Diego Bay cruises will resume Saturday, with new measures in place to help protect patrons and staff from the coronavirus.The daily harbor tour and Patriot Jet Boat cruises will open with limited capacity to allow for social distancing, and masks will be required for passengers and employees.Dinner cruises will resume May 29. The company is accepting reservations for all tours."We know it's been a difficult spring for everyone. We're excited to offer you a safe and easy escape. Come reconnect with our beautiful city and enjoy a much-deserved breath of fresh air," a company release reads.Flagship Cruises is celebrating its 105th anniversary in business this month. 747

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