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The transformation of 7% of Scott's DNA suggests longer-term changes in genes related to at least five biological pathways and functions.The newest preliminary results from this unique study of Scott, now retired from NASA, were released at the 2018 Investigator's Workshop for NASA's Human Research Program in January. Last year, NASA published its first round of preliminary results at the 2017 Investigator's Workshop. Overall, the 2018 findings corroborated those from 2017, with some additions.To track physical changes caused by time in space, scientists measured Scott's metabolites (necessary for maintaining life), cytokines (secreted by immune system cells) and proteins (workhorses within each cell) before, during and after his mission. The researchers learned that spaceflight is associated with oxygen-deprivation stress, increased inflammation and dramatic nutrient shifts that affect gene expression.In particular, Chris Mason of Weill Cornell Medicine reported on the activation of Scott's "space genes" while confirming the results of his separate NASA study, published last year.To better understand the genetic dynamics of each twin, Mason and his team focused on chemical changes in RNA and DNA. Whole-genome sequencing revealed that each twin has more than expected unique mutations in his genome -- in fact, hundreds.Although 93% of Scott's genetic expression returned to normal once he returned to Earth, a subset of several hundred "space genes" remained disrupted. Some of these mutations, found only after spaceflight, are thought to be caused by the stresses of space travel.As genes turn on and off, change in the function of cells may occur. 1676
The Washington Post first reported that Conroy rescinded his resignation.In the letter, he addressed speculation that lawmakers wanted a chaplain who wasn't Catholic."While you never spoke with me in person, nor did you send me any correspondence, on Friday, April 13, 2018 your Chief of Staff, Jonathon Burks, came to me and informed me that you were asking for my letter of resignation," he said in the letter. "I inquired as to whether or not it was 'for cause,' and Mr. Burks mentioned dismissively something like, 'maybe it's time that we had a Chaplain that wasn't a Catholic.'"He continued: "At that point, I thought that I had little choice but to resign, as my assumption was that you had the absolute prerogative and authority to end my term as House chaplain."Rep. Gerry Connolly, a Virginia Democrat who is Catholic, has been among the most vocal critics of the request for Conroy to step down."The letter is a bombshell, inside that bombshell are explosive items like Ryan's chief of staff actually said to him maybe it's a time for a non Catholic chaplain -- for Catholics that is a profoundly offensive comment," Connolly told CNN in a phone interview. "The more this festers, the uglier it gets and the wider this infection. I think Paul Ryan should see the letter as an opportunity to heal rather than pouring salt on an open wound."Connolly, who sent a letter with Jones to Ryan requesting more information on the resignation, said he spoke to Conroy before he wrote the letter and submitted it."My sense on (Conroy is) Jesuits are strong people and they're fighters and you don't mess with them," Connolly said. "We know in the Catholic church, you don't mess with Jesuits."Lawmakers from both parties were lobbied Ryan to take steps to rescind his request.Republican Rep. Walter Jones of North Carolina asked Ryan to reinstate Conroy on Wednesday, saying in a letter he believes the way the House chaplain was let go reflected "poorly on the House" and appears "intentionally underhanded.""Not only was I dismayed that Father Conroy was apparently asked to resign without explanation, I was troubled by the manner in which it was done. All members were not asked for their opinions on the chaplain's performance," Jones said in the letter. "Instead, it appears a decision to push him out was made behind closed doors based on the input of only a few."The letter continued: "It appears the decision was made to minimize the input of members, and executed surreptitiously to overcome what was likely to be their overwhelming objection. It appears intentionally underhanded, and that is deeply disappointing!"According to a person who attended last week's GOP conference meeting, the speaker explained that he asked Conroy to resign "based on member feedback about pastoral care."A separate GOP member who attended the meeting said Ryan "didn't say this as bluntly but the reason for the change is that many of us like Father Conroy but we feel like he didn't do anything. We never see him. We never hear from him. We'd like to have a more active priest/pastor." 3079

The suspected arsonist told officers that he was not doing anything and just trying to help put out the fire, but the witness said the man was “literally grabbing all this dry brush and he’s throwing it into the fire.” 218
The ruptured main sent water and mud into the air and onto the roadway, causing a section of the street to cave in and form a sinkhole. 135
The victim reportedly showed police photos of her injuries, which detectives wrote appeared to show broken bones, bruising and other injuries. 142
来源:资阳报