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Immunotherapy has gained ground against a stubborn opponent: ovarian cancer. A personalized cancer vaccine is safe and may lengthen the lives of ovarian cancer patients, a small clinical trial found.The research, published Wednesday in the journal Science Translational Medicine, showed "significantly higher" overall survival at two years among patients who received the vaccine, compared with patients who did not.Ovarian cancer is a "silent killer" because often it goes unnoticed until it is diagnosed at a late stage. Treated with surgery followed by chemotherapy, most patients -- 85% -- relapse and ultimately develop resistance to the chemo. At this point, they run out of treatment options.Still, scientists are hopeful based on the fact that a subset of patients shows an immune response to their cancer. Generally, these patients have better survival rates than those whose immune systems don't react in the same way.A vaccine, then, might be able to trigger and boost the immune system and increase the survival rates of patients, said Dr. Lana Kandalaft, senior author of the new study and an adjunct assistant professor at the University of Pennsylvania Perelman School of Medicine.  1210

IMPERIAL BEACH, Calif. (KGTV)— South Bay beaches are closed again, after millions of gallons of contaminated sewage water spilled from Tijuana, BC into Imperial Beach communities.It may look beautiful from afar, but up close, Giovanny Ceja says the waves were a little off Thursday afternoon. “We usually go to other beaches, and they look really clear, but that one was dirty and brown,” Ceja said.  Ceja and his little sister spent the day at Imperial Beach, near the south end of Seacoast Drive, boogie boarding and building sand castles. To get there, he walked right past many warning signs. Large yellow signs read: “KEEP OUT. SEWAGE CONTAMINATED WATER.”“It’s a completely unacceptable,” Imperial Beach City Councilwoman Paloma Aguirre says.According to the International Boundary Water Commission, a Tijuana water collector ruptured Wednesday night. That spilled 3.5 million gallons of sewage water into the Tijuana River, which gushed into South Imperial Beach. “It’s incredibly frustrating because this is the summer. This is our time to have open beaches in Imperial Beach,” Aguirre said. “It’s because of the incredible negligence that the state of Baja California authorities have shown and the lack of accountability and leadership from our federal agencies.”So far this year, there have been 50 beach closure days in Imperial Beach. Aguirre says as polluted water gushes into IB, quality of life gushes out. “At the end of the day Imperial Beach is at the end of the pipe,” Aguirre said. “We are the ones that are paying with economic losses, with illnesses to our kids, to our families, and to our environment.”As for little Giovanny, who did not notice the warning signs, now he is getting worried. “When I was boogie boarding the water wet in my mouth,” Ceja said. “I’ll shower. Maybe twice.”THe closure only affects beaches south of Seacoast Drive in Imperial Beach to the US-Mexico border. The IB Pier remains open. 1949

HUNTINGTON BEACH, Calif. (AP) -- A California man has been charged with poisoning eight homeless people with an incredibly spicy resin derived from chili peppers so that he could videotape their reactions.Authorities in Southern California's Orange County say 38-year-old William Robert Cable fed the victims food laced with oleoresin capsicum, which is twice as strong as pepper spray used by police.The victims suffered seizure-like symptoms, difficulty breathing, vomiting and intense mouth and stomach pain. Some had to be hospitalized.Cable was arrested last month in Huntington Beach and prosecutors announced Thursday that he's been charged with nine felonies and various misdemeanor counts.Cable is being held in jail on 0,000 bail. 751

IKEA is ending the publication of its iconic catalog after 70 years.The Swedish retailer cited the reason for ending it was due to consumers shopping online.IKEA said last year, their online retail sales increased by 45% worldwide, and they saw 4 billion users on its website."For both customers and co-workers, the IKEA Catalog is a publication that brings a lot of emotions, memories, and joy. For 70 years, it has been one of our most unique and iconic products, which has inspired billions of people across the world," said Konrad Grüss, Managing Director, Inter IKEA Systems B.V in a press release. "Turning the page with our beloved catalog is, in fact, a natural process since media consumption and customer behaviors have changed. To reach and interact with many people, we will keep inspiring with our home furnishing solutions in new ways."IKEA said they are transforming as a company and will focus more on "being more digital and accessible" by improving their digital services and launching new apps.“We are not starting from scratch. We have been transforming many aspects of how to reach and interact with our customers, and the work continues to find new ways to amplify unique IKEA home furnishing knowledge, products, and solutions in the best possible way - to inspire the many people through new ways, channels, and formats,” said Grüss.The company first released its catalog in 1951 in Sweden. At its peak in 2016, IKEA distributed 200 million copies in 69 different versions and 32 languages.In fall 2021, the company said a book would be released that'll be filled with "great home furnishing inspiration and knowledge." 1651

I just interrupted a press conference in Miami-Dade to let governor @RonDeSantisFL and @MayorGimenez know they are an embarrassment to FL and that their incompetence and lack of planning has resulted in the current public health crisis. 4,381 people have died so far in FL pic.twitter.com/q6SozHfT8o— Thomas Kennedy (@tomaskenn) July 13, 2020 350

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