济南小弟弟包皮肿了(济南勃起有障碍) (今日更新中)

WASHINGTON, Aug. 2 (Xinhua) -- The weakness of aging is associated with leaky calcium channels inside muscle cells and a drug already in Phase II clinical trials for the treatment of heart failure might plug those leaks, according to a report published Tuesday in the online edition of Cell Metabolism.Earlier studies by the research team led by Andrew Marks of Columbia University showed the same leaks underlie the weakness and fatigue that come with heart failure and Duchenne muscular dystrophy."It's interesting, normal people essentially acquire a form of muscular dystrophy with age," Marks said. "The basis for muscle weakness is the same." Extreme exercise like that done by marathon runners also springs the same sort of leaks, he added, but in that case damaged muscles return to normal after a few days of rest. A microscopic view shows smooth muscle cells derived from human embryonic stem cells showing the nuclei (blue) and proteins of the cytoskeleton (green) in this handout photo released to Reuters by the California Institute for Regenerative Medicine, March 9, 2009The leaks occur in a calcium release channel called ryanodine receptor 1 (RyR1) that is required for muscles to contract. Under conditions of stress, those channels are chemically modified and lose a stabilizing subunit known as calstabin1.Calcium inside of muscle cells is usually kept contained. When it is allowed to leak out into the cell that calcium itself is toxic, turning on an enzyme that chews up muscle cells. Once the leak starts, it's a vicious cycle. The calcium leak raises levels of damaging reactive oxygen species, which oxidize RyR1 and worsen the leak.The researchers made their discovery by studying the skeletal muscles of young and old mice. They also showed that 6-month-old mice carrying a mutation that made their RyR1 channels leaky showed the same muscular defects and weakness characteristic of older mice.When older mice were treated with a drug known as S107, the calcium leak in their muscles slowed and the animals voluntarily showed about a 50 percent increase in the amount of time spent wheel running. Now in clinical trials for patients with heart failure, the drug is known to work by restoring the connection between costabilin and RyR1.Despite considerable effort to understand and reverse age- related muscle wasting, there are no established treatments available. The new work suggests there may be hope in approaching the problem from a different angle."Most research has focused on making more muscle mass," Marks said. "What's different here is that we are focused not on muscle mass but on muscle function. More muscle doesn't help if it is not functional."

BERLIN, June 9 (Xinhua) -- A 57-year-old man died of E. coli infection in Germany's Frankfurt Thursday, pushing the death toll from the bacteria to 30.The man had traveled with his wife to the city of Hamburg, an epicenter of the outbreak, Frankfurt authority said.Another two deaths were reported in the state of Lower Saxony, including a 68-year-old man and a 20-year-old woman, while more than 2,800 people in 14 countries have been infected since the deadly E. coli outbroke.German researchers detected again the deadly strain o104 of E. coli on the scraps of cucumbers in a dustbin in the eastern city of Magdeburg in the state Saxony-Anhalt on Wednesday.German health minister Daniel Bahr expressed his cautious hope for the disease on Wednesday as the number of new infection is clearly going down.But he also admitted there will be new cases and more deaths have to be expected, as Germany's national disease control centre, the Robert Koch Institute reported more than 300 infection in Germany on the same day.The Robert Koch Institute also noticed the declining trend in new cases but it was not clear whether this was caused by people staying away from vegetables or the outbreak was truly waning.

WASHINGTON, June 16 (Xinhua) -- Cells in the human body are constantly being exposed to stress from environmental chemicals or errors in routine cellular processes. While stress can cause damage, it can also provide the stimulus for undoing the damage. New research by a team of scientists at the University of Rochester has unveiled an important new mechanism that allows cells to recognize when they are under stress and prime the DNA repair machinery to respond to the threat of damage.Their findings will be published Friday in journal Science. Cells in the human body are constantly being exposed to stress from environmental chemicals or errors in routine cellular processes. While stress can cause damage, it can also provide the stimulus for undoing the damage.The scientists, led by biologists Vera Gorbunova and Andrei Seluanov, focused on the most dangerous type of DNA damage -- double strand breaks. Unrepaired, this type of damage can lead to premature aging and cancer. They studied how oxidative stress affects efficiency of DNA repair. Oxidative stress occurs when the body is unable to neutralize the highly-reactive molecules, which are typically produced during routine cellular activities.The research team found that human cells undergoing oxidative stress synthesized more of a protein called SIRT6. By increasing SIRT6 levels, cells were able to stimulate their ability to repair double strand breaks. When the cells were treated with a drug that inactivated SIRT6, DNA repair came to a halt, thus confirming the role of SIRT6 in DNA repair. Gorbunova notes that the SIRT6 protein is structurally related to another protein, SIR2, which has been shown to extend lifespan in multiple model organisms."SIRT6 also affects DNA repair when there is no oxidative stress," explains Gorbunova. "It's just that the effect is magnified when the cells are challenged with even small amounts of oxidative stress."SIRT6 allows the cells to be economical with their resources, priming the repair enzymes only when there is damage that needs to be repaired. Thus SIRT6 may be a master regulator that coordinates stress and DNA repair activities, according to Gorbunova.

JAKARTA, Sept. 21 (Xinhua) -- Comprehensive efforts are needed to save coral reefs as their living compound is prone to environmental damage, an Indonesian expert told Xinhua in an exclusive interview on Tuesday.Nurul Dhewani Mirah Sjafrie, coordinator of Coral Reef Information and Training Center (CRITC) for western Indonesia at the Indonesian Science Institute, the government think-tank institution, said that currently only more than five percent of coral reefs in Indonesia are in "excellent condition.""Based on monitoring of the thousands of observation stations we have, the rest are in damage, bad and moderate condition," Sjafrie said in her office.She said that it is not impossible to increase the number as long as all people are aware of the importance to save coral reefs."People should be aware that coral reefs live in sea with warm enough temperature of 18-25 Celsius degree with certain level of brightness, among others. If the requirements are fulfilled, we can see coral reef growing safely," said Sjafrie.She also said it needs upstream-to-downstream arrangement to support the efforts."For example, in western Indonesia, we have many big rivers. If illegal logging practice keeps continuing, it will cause sedimentation in the sea. It means there is a decreasing quality. So, coral reef salvation is not only conducted in ocean," Sjafrie said.She also expressed concern that many people dump garbage in rivers."They throw their garbage in plastic bags. For plastic only, it takes 100 years to be completely decomposed. Let's say 10-15 percent of our people do the malpractice everyday, you can imagine how many garbage entering the sea," she said.Sjafrie said that the key to guard coral reef sustainability is in human habit."Coral reef destruction could be caused by nature such as tsunami, earthquake, crown torn (Acanthaster plancii) that consumes coral reefs. But the biggest factor is human with their destructive fishing using bombs," she said.According to Sjafrie, people do the practice with three causes, namely ignorance, needs and greed.She added that efforts have been conducted by the government, private sector and non governmental organizations (NGOs) to save coral reefs."We have a program called the CORMAP of Coral Reef Rehabilitation and Management Program. The government uses instrument of National Program of People Empowerment while NGOs do their part. If we could combine the actions, we could reach the same goal," she said.She added that the government train people to be productive by providing skills and in the same time, her organization and NGOs socialize and campaign the importance of coral reefs."When people have better jobs and activities and they are equipped with the awareness, they will do positive thing and stop destroying the sea," Sjafrie said.

TAIYUAN, May 29 (Xinhua) -- Parents of children with cerebral palsy are going to have a place to turn for help, as the first public foundation to provide aid has been set up in northern Shanxi Province.The Brain Rehabilitation Fund was established on Saturday by the China Population Welfare Foundation (CPWF), which is headquartered in Beijing. The CPWF will cooperate with the Shanxi Cerebral Palsy Hospital, which specializes in curing the brain disease with therapies such as acupuncture and massage.Lan Ye, the deputy secretary general of the CPWF, said the fund aims to relieve the burden of affected families by providing financial assistance and training so parents are able to do the therapy at home. In addition, the fund hopes to reduce the incidence of cerebral palsy by publicizing preventative measures to thwart the disease.More than 6 million suffer from cerebral palsy in China, and among them more than 2 million are children, said Guo Xinzhi, vice president of the Shanxi's Federation of the Disabled."A family needs to spend more than 500,000 yuan (77,000 U.S. dollars) to cure a child with the disease," Guo said. "As 70 percent of the children with cerebral palsy are from poor, mountainous areas, more than 25.7 percent of families cannot afford to pay the medical expenses."On Saturday, 25 parents from Xinjiang Uygur Autonomous Region, Fujian, Henan and Shanxi provinces came to the hospital for free training on helping their children to recover at home.

来源：资阳报