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Could the no-calorie sweetener you rely on to replace sugar in your diet actually cause weight gain instead of the weight loss you were expecting?The answer may be yes, according to a new study."Artificial sweeteners are not risk-free," said Brian Hoffmann, assistant professor in the Department of Biomedical Engineering at the Medical College of Wisconsin and Marquette University, and a lead author of the study. "They are a very controversial topic when it comes to health and nutrition ... but they're so prevalent in society that I think we owe it to ourselves to try and figure out what's actually going on."Hoffmann presented his new research Sunday at the annual?Experimental Biology meeting in San Diego. Relying on rats and human cell cultures, his team identified a number of pathways linking artificial sweeteners with metabolic changes at the genetic level that could lead to diabetes and obesity. Specifically, the researchers found that three weeks of exposure to aspartame and acesulfame potassium -- two artificial sweeteners frequently combined in products such as Equal -- altered the expression of certain genes responsible for lipid metabolism in the cells of both rats and humans."Aspartame had some significant changes, and one of those was an increase in lipids in the bloodstream and a decrease in a biomolecule that is involved in clearing (lipids) from the bloodstream. And we saw the exact same thing with the acesulfame potassium," Hoffmann said."We then took those particular sweeteners and put them on endothelial cells -- the cells that line the blood vessels and would be exposed to them in the body -- and we detected a marked dysfunction, suggesting why sweeteners and diet soda have been linked to potential cardiovascular problems," he added.What was perhaps most surprising, according to Hoffmann, was that these metabolic changes did not occur in the presence of natural sugars such as glucose and fructose. This suggests that artificial sweeteners could contribute to metabolic disorders such as diabetes and obesity by an entirely different mechanism than natural sugars, he said.Artificial sweeteners appear to contribute to metabolic disorders by altering the activity of certain genes responsible for the breakdown of macromolecules such as fats and proteins, Hoffmann said. This is different from normal sugars, which contribute to cardiovascular disease through insulin resistance and by damaging the cells lining the body's blood vessels."People are generally consuming non-nutritive sweeteners believing they are a 'healthy choice,' but this may not be true," said research scientist Meghan Azad of the University of Manitoba in Winnipeg, who was not involved in the new study."This is especially important given the widespread and increasing consumption of artificial sweeteners in the general population and the increasing use of artificial sweeteners in our food supply," said Azad, who has authored a paper that reviewed a number of studies on the potential downside of artificial sweeteners on weight and health.According to Azad, over 40% of adult Americans consume no-cal sweeteners on a daily basis, and studies that measure the sweeteners in blood and urine show that many people who report not using artificial sweeteners are unknowingly consuming them.It's the latest assault in the ongoing debate over artificial sweeteners and their impact on health -- a debate that began when one of our most popular foods, sugar, turned sour in terms of health. 3527

Cori Bush, a onetime homeless woman who led protests following a white police officer’s fatal shooting of a Black 18-year-old in Ferguson, has ousted longtime Rep. William Lacy Clay in Missouri’s Democratic primary. Bush’s victory came in a rematch of 2018, when she failed to capitalize on a national Democratic wave that favored political newcomers such as Bush’s friend, Rep. Alexandria Ocasio-Cortez. But this time around, Bush’s supporters said protests over George Floyd’s death and outrage over racial injustice finally pushed her over the edge. An emotional Bush, speaking to supporters while wearing a mask, said few people expected her to win.“They counted us out,” she said. “They called me — I’m just the protester, I’m just the activist with no name, no title and no real money. That’s all they said that I was. But St. Louis showed up today.”Bush’s campaign spokeswoman, Keenan Korth, said voters in the district were “galvanized.”Missouri’s 1st Congressional District, which which encompasses Ferguson, has been represented by the 64-year-old Clay or his father for a half-century. Bill Clay served 32 years before retiring in 2000, when William Lacy Clay was elected. 1191

Companies are trying to figure out what working remotely will look like long-term.Facebook expects half of its workforce to work remotely within the next 10 years. That can mean both positives and negatives.“We actually have the ability to diversify the workforce in a way we never really could before, because of the constraints that are around housing,” said Jennifer Stojkovic, Executive Director at sf.citi, a nonprofit organization developed to empower the San Francisco tech community to have a voice in local policy decisions.Some of the positives include diversity, flexibility, cheaper cost of living, and work-life balance.Many companies could end up following in the footsteps of big tech and going with a corporate head office and communal space for teams to get together.“Right now, that getting together might look like once a week, but if these teams start to decentralize, that getting together might look like once a month the entire team flies in,” said Stojkovic.Some workers may not work well at home.“There are a range of taxing mental health issues arising from COVID-19 and working from home for prolonged periods of time is one of them,” said Dr. Jason Rao at Cornell University.JPMorgan Chase just announced productivity and creativity at the company have taken a hit. Some of their employees are being required to return to offices next week.Salary experts say you may be able to use long-term remote work as a negotiation tool if your company freed salaries or had cuts or furloughs.Senior managers are worried about retaining top talent.“From the get-go, we're seeing it advertised, companies that are giving us openings and reacquisitions to work on are talking about it right away,” said Paul McDonald, Senior Executive Director at Robert Half.If you're changing jobs and starting remotely, job experts say it’s important to ask about the long-term – if the position will stay remote, be hybrid or will eventually return to the office full-time. 1983

CORONADO, Calif. (KGTV) -- A 21-year-old sailor died after falling from the USS Nimitz Friday night. According to U.S. Naval Air Forces, the sailor fell from one of the ship’s aircraft elevators. The USS Nimitz was in port at Naval Air Station North Island. The 21-year-old suffered serious injuries from the fall and died Saturday morning, according to the Navy. The name of the sailor hasn’t been released at this time and the nature of the accident is under investigation. A sailor from USS Nimitz passed away early this morning from injuries sustained in an accident aboard ship last night. The sailor fell from one of the ship’s aircraft elevators in a down position. The accident is under investigation.— flynavy (@flynavy) September 28, 2019 757

Conditions at the border are getting worse as desperate migrants wait for asylum. Many have given up hope in their desperate hour. The shelter where migrants are staying is packed to the brim. It’s said to be completely full and actually three times above capacity. Conditions are getting worse as officials with the state’s special committee on migration issues say city and state officials are even looking for a second shelter, but no local businesses are willing to rent out their facilities for the migrants. People at the shelter have reported deteriorating conditions including open sewage drains. The Mexican Navy has set up small kitchens and the Red Cross is providing medical care. Migrants say they want the U.S. to speed up the political asylum process, saying it’s taking too long. 804

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