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SAN DIEGO (KGTV) — The holiday season is underway in San Diego, as locals prepare to jump into December this weekend.Outdoor ice skating can be found at Viejas Casino and Resort's massive outdoor ice rink, and Carlsbad welcomes the "big man" to town to help light their Christmas tree!Legoland also jumps into the season with Holidays at Legoland and several street festivals and art shows give you the chance to get a jump on holiday shopping for friends, family, and pets!Not interested in anything here? Check out the 10News?community events calendar for a look at even more things to do!But Thanksgiving is first on the list. The 72nd annual Mother Goose Parade in El Cajon will ring in the season for being together with family and friends, as local gather to watch floats, bands, and Santa glide through town.Here's a look at this weekend's big events:THURSDAYOutdoor ice skating at ViejasWhere: Viejas Casino & Resort; Cost: - (Runs Thursday - Sunday) Holiday lights and entertainment have arrived at Viejas! Get into the winter spirit with ice skating at one of the biggest Southern California rinks around. A 90-minute session for kids will run while adults and teens can skate for . Art of the Holiday?ShowWhere: Fallbrook Art Center; Cost: Free(Runs Thursday - Saturday) Explore handmade crafts and jewelry by talented artists at Fallbrook Art Center's free Art of the Holiday Show. Wearable art, glass and ceramics, ornaments, and more can be found as a unique and creative gift this season! FRIDAYTree Lighting & Santa ArrivalWhere: Carlsbad Premium Outlets; Cost: FreeWelcome in the holiday season with Santa as he helps light Carlsbad's outlet Christmas tree. Enjoy holiday performances by Samantha Robertson, Singers Company, and the Carlsbad Company Theatre as well, and get a start on your holiday shopping. Del Mar Antique Show & SaleWhere: Del Mar Fairgrounds; Cost: Free(Runs Friday - Sunday) Del Mar Fairgrounds will be packed with vintage collectibles and antiques spanning glass, pottery, jewelry, art, and much more at the Antique Show & Sale. Have your own treasure? Appraisal team members can take a look and see if you've struck vintage gold! SATURDAYPadres Pedal the CauseWhere: Petco Park; Cost: - 5Pedal the Cause rallies the San Diego community to raise awareness and funding for cancer research in San Diego. The challenge includes four cycling courses, spin classes, or a 5K run/walk ending in centerfield inside Petco Park! You choose! Holidays at LegolandWhere: Legoland California; Cost: (Runs Saturday - Sunday) Holiday magic kicks off at Legoland, where a 30-foot high Lego Christmas tree will play centerpiece to a park full of holiday cheer. Make sure to visit Lego Santa and a cast of characters at the new Holiday Village! 10th Annual Doggie Street FestivalWhere: Liberty Station; Cost: FreeLiberty Station's Doggies Street Festival brings together live entertainment, auctions, and, of course, everything cats and dogs for pet owners and those looking to adopt a furry friend. Visit with rescue societies and get tips from vets and pet services, and bring your own doggo to enjoy the festival too!  SUNDAY72nd annual Mother Goose ParadeWhere: El Cajon; Cost: FreeEl Cajon's Mother Goose parade is billed as the largest parade in San Diego County! Celebrate Thanksgiving as thousands line the streets to watch Santa, marching bands, and more as the parade begins on Main St. at El Cajon Blvd. marching toward First St. 28th annual Encinitas Holiday Street FairWhere: Downtown Encinitas; Cost: FreeHead out for free fun in Encinitas, including two stages of live entertainment, delicious food, children's rides and games, and more during the Encinitas Holiday Street Fair. Vendors will also be out giving guests the chance to get some holiday shopping done, offering handmade crafts, art, and more! Taco TKOWhere: Liberty Station; Cost: Help discover San Diego's best taco during an all-you-can-eat taco showdown at Liberty Station! Taco TKO pits local restaurants against each other for the title of "San Diego's Most Awesome Taco," as part of the San Diego Bay Wine + Food Festival. 4299

SAN DIEGO (KGTV) — The National Institutes of Health highlighted research Tuesday out of UC San Diego that could unlock a new way to treat COVID-19.The research reveals new insight into how the coronavirus hijacks cells, and how doctors might be able to set traps or decoys to combat the virus. The findings were published in the journal Cell last month.“It does open up another avenue for a potential treatment,” said UC San Diego distinguished professor Dr. Jeffrey Esko. “It’s not a cure. It would be something that would tamp down infection potentially.”Since January, scientists around the world have understood that SARS-Co-V2, the official name of the new coronavirus, enters cells by latching onto a specific receptor on the cell’s surface, called ACE2.The UCSD team, led by Dr. Esko and visiting scholar Dr. Thomas Clausen, discovered that this entry mechanism is actually a two-step process, and the virus must also attach to a long chain of sugars called heparan sulfate.“We’ve shown this is fundamental to the infectious mechanism, so it needs to be part of every study from now on,” said Clausen.All cells are coated with a complex layer of sugars, or carbohydrates, called glycans. Heparan sulfate is one type of glycan that is known to play a key role in the infection process in several viruses, including herpes and other coronaviruses.It’s a complicated process to picture so the researchers offer an analogy: imagine a bird, soaring over trees, hunting a worm on the forest floor. The bird is the coronavirus and the trees are the thick layer of glycans that coat the surface of the cell.To reach the worm, which in this case is the receptor ACE2, the bird must navigate its way through the trees, specifically through heparan sulfate.The UCSD found that by removing the heparan sulfate trees with an enzyme, they were able to prevent the virus from infecting cells. In laboratory testing, they also found a second technique worked to foil the virus: introducing more trees as bait.The team found that heparin, an FDA-approved drug that is similar in structure to heparan sulfate, successfully acted as decoy. Heparin is a widely used drug designed to treat blood clots. Since blood clots and strokes are common complications with COVID-19, many doctors already administer heparin to patients.The UCSD team demonstrated that the two approaches can block infection in lab-grown cells about 80 to 90 percent of the time.“Certainly in the laboratory you can demonstrate that it works, but to deploy it and use it as a therapeutic has not been demonstrated,” Esko said.The NIH noted that more studies are planned to explore whether heparin, heparan sulfate, or drugs that target heparan sulfate might yield a viable COVID-19 treatment.Dr. Esko said he’s already been in talks with companies that plan to use their study as a rationale for a clinical trial.“It is very humbling when you realize we’re working on a pandemic right now, and maybe what we’ve done can contribute to a treatment for the disease,” he said. 3038

SAN DIEGO (KGTV) — The holidays are approaching, giving San Diego plenty of things to do — in addition to any last-minute shopping — this weekend.San Diegans looking for holiday cheer can enjoy nightly snowfall in Eastlake, Jungle Bells fun at the San Diego Zoo, and ice skating around town.California County Christmas returns to Pacific Beach, packing Moonshine Beach with more than a dozen bands for a massive benefit concert and toy drive. A "Merry-Achi Christmas" comes to Balboa Theatre, where Mariachi Sol de México will serenade audiences with Christmas classics from Mexico and America.RELATED:10 special holiday events coming to San DiegoQuaint mountain towns near San Diego County to visit this holiday seasonHoliday parades: Festive San Diego parades to catch this seasonMap: Best Christmas lights to see in San DiegoSan Diego's annual Holiday Half Marathon returns to take runners down the Sr-56 bike path to Torrey Pines for a fun run before the holidays. And Ballast Point celebrates Victory at Sea Day with some pirate-themed fun around one of their most popular brews.THURSDAYA Merry-Achi ChristmasWhere: Historic Balboa Theatre; Cost: Tickets start at Celebrate the season with a special performance by three-time Grammy-Award nominee Mariachi Sol de México at the Balboa Theatre. The 13-piece ensemble brings the sounds of the season to the stage with Mexican and American Christmas songs and carols.6th annual California Country ChristmasWhere: Moonshine Beach; Cost: Free with donation of an unwrapped toy or donation at doorEnjoy an old fashioned, country-style holiday celebration in Pacific Beach at Moonshine Beach, where their annual Christmas toy drive and benefit concert will bring holiday cheer to the coast. More than a dozen bands will play throughout the night and guests will enjoy a silent raffle, line dancing and two-step competitions, and more.FRIDAYNightly snowfall at Village WalkWhere: Village Walk at Eastlake; Cost: Free(Thursday - Sunday) Village Walk at Eastlake turns into a winter wonderland this month with daily snowfall at 1 p.m., 2 p.m., and 3 p.m., then again at 6 p.m. and 7 p.m. from Dec. 7 - 24. From 12 p.m. to 3 p.m. everyday, kids can grab a photo with Santa and get a free coloring book.Jungle BellsWhere: San Diego Zoo; Cost: - (Thursday - Sunday) The San Diego Zoo's holidays are sure to be wild with Jungle Bells, with daily light shows, live entertainment, and an all new "aurora" light experience blends 3-D projections with music and lights into a dazzling show.SATURDAYSan Diego Holiday Half MarathonWhere: Rancho Pe?asquitos; Cost: -9Lace up your running shoes and hit the ground for San Diego's annual Holiday Half Marathon starting in Rancho Pe?asquitos, and leading runners along the State Route 56 bike path all the way to beautiful Torrey Pines State Beach. The race finishes with entertainment and awards and — hopefully — a new race record under your belt.Holiday Market at Societe Brewing CompanyWhere: Societe Brewing; Cost: Free to attendSpeaking of Societe Brewing, they'll be hosting a holiday market in their parking lot this month, with local vendors offering goods perfect for holiday shopping. Every dollar purchased at the market will also go towards every full pour inside their tasting room.Winter Wonder: Beachside at Belmont ParkWhere: Belmont Park; Cost: FreeSan Diego's 94-year-old theme park by the sea comes alive this month with Winter Wonder at Belmont Park. The event features a holiday toy drive, holiday sculptures, free photos with Santa, and other winter-themed activities and entertainment.SUNDAYLiberty Station Hanukkah and Menorah Lighting CelebrationWhere: Liberty Station Arts District; Cost: Free to attendTo ring in the Hanukkah festivities beginning on Dec. 22, Liberty Station will hold a public menorah lighting, featuring music and other holiday festivities for families. The lighting will take place near the Rady Children's ice rink, giving families another fun holiday option. More Hanukkah events around San Diego.Ballast Point: Victory at Sea DayWhere: Ballast Point Brewing Company; Cost: Fans of craft beer will surely enjoy Ballast Point's celebration of their Victory at Sea brew, and several of its variations, at the brewery's local tasting rooms this weekend. Victory at Sea Day gives drinkers the chance to sample the brewer's varieties of their popular stout, complete with a commemorative goblet, sticker, and eye patch. Pirate costumes "aarrrgh" highly encouraged.Skating by the SeaWhere: Hotel del Coronado; Cost: -Where else can you glide along the ice right next to the surf? This rink at the Hotel del Coronado’s Windsor Lawn is built every holiday season. Part of your admission supports San Diego’s Make-A-Wish Foundation. More places to ice skate in San Diego. 4830

SAN DIEGO (KGTV) — The National Institutes of Health highlighted research Tuesday out of UC San Diego that could unlock a new way to treat COVID-19.The research reveals new insight into how the coronavirus hijacks cells, and how doctors might be able to set traps or decoys to combat the virus. The findings were published in the journal Cell last month.“It does open up another avenue for a potential treatment,” said UC San Diego distinguished professor Dr. Jeffrey Esko. “It’s not a cure. It would be something that would tamp down infection potentially.”Since January, scientists around the world have understood that SARS-Co-V2, the official name of the new coronavirus, enters cells by latching onto a specific receptor on the cell’s surface, called ACE2.The UCSD team, led by Dr. Esko and visiting scholar Dr. Thomas Clausen, discovered that this entry mechanism is actually a two-step process, and the virus must also attach to a long chain of sugars called heparan sulfate.“We’ve shown this is fundamental to the infectious mechanism, so it needs to be part of every study from now on,” said Clausen.All cells are coated with a complex layer of sugars, or carbohydrates, called glycans. Heparan sulfate is one type of glycan that is known to play a key role in the infection process in several viruses, including herpes and other coronaviruses.It’s a complicated process to picture so the researchers offer an analogy: imagine a bird, soaring over trees, hunting a worm on the forest floor. The bird is the coronavirus and the trees are the thick layer of glycans that coat the surface of the cell.To reach the worm, which in this case is the receptor ACE2, the bird must navigate its way through the trees, specifically through heparan sulfate.The UCSD found that by removing the heparan sulfate trees with an enzyme, they were able to prevent the virus from infecting cells. In laboratory testing, they also found a second technique worked to foil the virus: introducing more trees as bait.The team found that heparin, an FDA-approved drug that is similar in structure to heparan sulfate, successfully acted as decoy. Heparin is a widely used drug designed to treat blood clots. Since blood clots and strokes are common complications with COVID-19, many doctors already administer heparin to patients.The UCSD team demonstrated that the two approaches can block infection in lab-grown cells about 80 to 90 percent of the time.“Certainly in the laboratory you can demonstrate that it works, but to deploy it and use it as a therapeutic has not been demonstrated,” Esko said.The NIH noted that more studies are planned to explore whether heparin, heparan sulfate, or drugs that target heparan sulfate might yield a viable COVID-19 treatment.Dr. Esko said he’s already been in talks with companies that plan to use their study as a rationale for a clinical trial.“It is very humbling when you realize we’re working on a pandemic right now, and maybe what we’ve done can contribute to a treatment for the disease,” he said. 3038

SAN DIEGO (KGTV) -- The majority of residents at Reo Vista Healthcare Center in Paradise Hills have COVID-19, according to officials with the facility.A total of 112 residents have tested positive, according to the facility’s administrator Curtis White. 40 staff members also tested positive for COVID-19. White confirmed 14 residents have passed away. Of that number, five died in local hospitals.The facility holds 135 residents.Juanita Gomez was one of the residents who tested positive. Her son told Team 10 she passed away July 1st.The state strike team assisted in expediting testing for residents and staff, White said. They have visited the facility three times.Cesar Noriega’s 90-year-old mother also tested positive. She is currently in the hospital dealing with COVID-19 and other health related issues. “She’s not doing well. She’s in a lot of pain,” Noriega said. Noriega said he urged early testing at the facility, but his pleas for help went ignored. He is now trying to figure out where his mother can get care after she is released from the hospital.“I’ve gone through elation, through depression, to anger… this is almost on a daily basis,” Noriega said.White said “most of the individuals with COVID are experiencing mild or no symptoms.” 13 residents and 23 staff members have recovered.“Our top priority remains the health and well-being of everyone in our facility,” White said. 1409