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A third leading candidate COVID-19 vaccine has entered a final stage of human testing in the United States. AstraZeneca announced Monday its potential COVID-19 vaccine has entered final trials in the U.S. to test the effectiveness and safety of the product. The Cambridge, England-based company said the trial will involve up to 30,000 adults from various racial, ethnic and geographic groups. The potential vaccine was invented by the University of Oxford and an associated company, Vaccitech.AstraZeneca said development of the vaccine known as AZD1222 is moving ahead globally with late-stage trials in the U.K., Brazil and South Africa. Further trials are planned in Japan and Russia.“To have just one vaccine enter the final stage of trials eight months after discovering a virus would be a remarkable achievement; to have three at that point with more on the way is extraordinary,” Health and Human Services Secretary Alex Azar said in a statement.Two other vaccine candidates began final testing this summer in tens of thousands of people in the U.S. One was created by the National Institutes of Health and manufactured by Moderna Inc., and the other developed by Pfizer Inc. and Germany’s BioNTech. 1215

A military helicopter carrying officials surveying earthquake damage crashed Friday night in the southeastern Mexican state of Oaxaca, killing at least 13 people, Mexican officials said.Twelve people died at the site of the crash in Santiago Jamiltepec, while another person died in the hospital, the state attorney general's office said. Three of the dead were children, the office said. Fifteen others were injured.It is unclear how many of the victims were on the helicopter and how many were on the ground.Mexican Interior Minister Alfonso Navarrete Prida and Oaxaca's governor, Alejandro Murat, were flying near the quake's epicenter to evaluate damage when the helicopter crashed. Both men survived and only suffered "slight concussions," the Interior Ministry tweeted. The 7.2 magnitude earthquake and a magnitude 5.8 aftershock -- both with epicenters in Oaxaca state -- struck the region Friday, the US Geological Survey reported.Mexican President Enrique Pe?a Nieto said the crash took place while the helicopter was landing."Unfortunately, people on the ground lost their lives and others were wounded. My condolences to their families and my wishes for a prompt recovery to those injured," the President tweeted.When addressing the helicopter crash on Twitter, Pe?a Nieto said there were no reports of fatalities directly linked to the quake and aftershock.Efrain de la Cruz, mayor of Santiago Jamiltepec, was on the phone with CNN en Espa?ol's Mario González when the crash occurred."A helicopter carrying the governor and the others went down," he said."A helicopter is down, a helicopter is down. Oh my God! It's a military helicopter," Cruz said. "This can't be possible, oh my God."The-CNN-Wire? & ? 2018 Cable News Network, Inc., a Time Warner Company. All rights reserved. 1803

A starting point for investigators trying to trace the bombs sent to Democratic figures and CNN this week: the postmark.But in some cases, it appears to be a missing clue.The postmark typically indicates when and where the mail was sent from and is marked over the stamps -- "canceling" them, and preventing the stamps from being reused. Unlike stamps, most of which cannot be traced, the impression left by a postmark or mail meter is distinctive and can help investigators focus their search.A postmark is visible in a photo of at least one of the packages seen by CNN. A postmark is not visible in photos of several other packages shared with CNN -- only adding to the questions about their origins.The lack of a postmark is very rare, according to Nancy Pope of the National Postal Museum.A postal inspector who spoke to CNN on the condition of anonymity indicated it would be very unusual for a piece of mail to leave the facility where it was dropped off for delivery without such a mark.That could indicate that a sender or senders were working in multiple diverse geographical areas, including New York, Washington, Florida and California.Another source told CNN it is possible some of the stamps may not have been canceled because of the package's soft sides and odd shape, which would make it difficult to stamp.The US Postal Service's website also says mail may not be postmarked if it was processed through a meter or if the postage was paid by permit or precanceled stamp. None of those appear to apply to this situation.Adding to the mystery are post office markings on one of two packages sent to former Vice President Joe Biden indicating the stamps on the package did not cover the cost of the delivery, and additional postage is due.That suggests the package was weighed at some point during the shipping process, a former postal inspector told CNN.It was unclear from the photo whether that package had been postmarked.Postmarks can be applied by machine and by hand, depending on how a piece of mail is sent, according to the Postal Service. When mail is run through an automated system at a processing distribution center, the postmark is applied, and the mailed item is screened by a biohazard detection system.It was not clear why postmarks were not visible on several of the packages, and the US Postal Inspection Service provided a statement to CNN that did not address the question."The U.S. Postal Service has developed a comprehensive approach to protecting the mailsystem by utilizing a targeted strategy of specialized technology, screening protocols and employee training," read the statement.The statement noted its Dangerous Mail Investigations Program includes law enforcement officers who "are trained to recognize the common characteristics of suspicious mail and are highly proficient in the use of state-of-the-art equipment to include portable X-ray machines." 2907

A new medical device promises to diagnose a concussion in under four minutes and its creators are backed by a unique partnership between the NFL's Green Bay Packers and Microsoft.The world of traumatic brain injuries and concussions is filled with gray matter. The diagnosis is subjective and every doctor manages it differently as the injury is just as complex as the brain.“When you have a heart attack and go into the ER, you get five objective tests. If you get a brain injury and you go into the ER, you get, ‘Follow my finger, what month is it, who’s the president?’ We have to do better for brain-injured patients,” Dr. Rosina Samadani, CEO of Oculogica, said.Samadani developed a device called the "Eye Box.” Her sister, a neurosurgeon, discovered the technology.“Where it really came from was noticing that when there’s a deficit in the cranial nerves, there is a deficit in eye movements and there is that same deficit that occurs in concussed patients.,” Samadani said.So, she created an algorithm based on those eye movements, which is how the Eye Box was born.“We’re looking at your pupils, we’re tracking them and having you perform a simple task,” Samadani said. “You watch a video as it moves around the screen and we watch your eyes watching that video and that’s it.”The sisters took the idea to TitletownTech.“We look for exceptional founders who are solving meaningful problem,” said Jill Enos, the managing director of TitletownTech.The venture capital fund builds and invests in startups.“TitletownTech was formed out of this improbable partnership between the Green Bay packers and Microsoft, both of whom shared a common interest in advancing the technology capabilities of the region but also in leveraging the strength of startups and founders as economic drivers in the regional economy,” Enos said.Enos says Oculogica immediately caught their attention. And that is no easy feat. In just 15 months, more than a thousand ideas have crossed their desk. They've invested in 20; several are women and minority led.“As someone who is in venture capital, which is also not a very common women focused industry, it was great to see two strong founders that we could connect with and get behind,” says Enos.“We don’t feel that we’re so different than our peers but we are. We know we are and with that, we feel there is a great deal of responsibility,” Samadani said.She wants girls to love math and science like she does. And she says to realize that the sky is the limit.“We’re also very excited to show other women and young girls they can do this and women can be great at math and science. I wake up every single day and I’m so excited about what I’m doing and we’re changing the world of brain injury. Any woman, any young girl, can grow up to do this and that’s fantastic,” said Samadani.Oculogica is already authorized by the FDA, and the insurance and reimbursement codes are being worked out now. Some clinics already have it, and more are expected.“The best feeling is when we get a call from a mom or dad who says, ‘I'm so relieved we now know what’s going on,'” Samadani said. "'I didn’t know where to turn it.’ Just relieves their anxiety that is everything- absolutely everything when we get a call like that.” 3253

A St. Louis couple who waved guns at peaceful protesters near their property earlier this year will speak in support of President Donald Trump next week at the Republican National Convention, The Washington Post, NPR and CNN report.The couple will reportedly deliver remarks remotely, as in-person portions of the convention have been canceled.Mark and Patricia McCloskey gained national attention in late June as Black Lives Matter protesters marched toward the home of St. Louis Mayor Lyda Krewson. Krewson and the McCloskeys live in a private, gated community.Though the protesters were peaceful and staying away from the McCloskey's mansion, the couple emerged from their homes with firearms and ordered protesters to leave.Various social media videos show Patricia McCloskey pointing a small handgun at protesters. Mark McCloskey carried a long gun.In July, the couple was charged with unlawful use of a weapon for waving the guns in a "threatening" manner. Both have maintained their innocence, saying they were afraid for their lives and were simply protecting themselves.The White House has previously expressed support for the couple. Press Secretary Kayleigh McEnany said in July that the charges against the McCloskeys were "absurd." Missouri Gov. Mike Parson has also said he's spoken with Trump about the situation.The RNC will take place next week between Aug. 24 and Aug. 27. 1398