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CFD Units are currently on scene in the 9500 Block of David Taylor Dr; heavy flooding has lead to the evacuation of a Charter School; no injuries at this time; 143 persons have been rescued pic.twitter.com/ltDWL2CF4F— Charlotte Fire Dept (@CharlotteFD) November 12, 2020 278

Bulked-up, mutant “mighty mice” held onto their muscle during a monthlong stay at the International Space Station, returning to Earth with ripped bodybuilder physiques, scientists reported Monday.The findings hold promise for preventing muscle and bone loss in astronauts on prolonged space trips like Mars missions, as well as people on Earth who are confined to bed or need wheelchairs.A research team led by Dr. Se-Jin Lee of the Jackson Laboratory in Connecticut sent 40 young female black mice to the space station in December, launching aboard a SpaceX rocket.In a paper published in the Proceedings of the National Academy of Sciences, Lee said the 24 regular untreated mice lost considerable muscle and bone mass in weightlessness as expected — up to 18%.But the eight genetically engineered “mighty mice” launched with double the muscle maintained their bulk. Their muscles appeared to be comparable to similar “mighty mice” that stayed behind at NASA’s Kennedy Space Center.In addition, eight normal mice that received “mighty mouse” treatment in space returned to Earth with dramatically bigger muscles. The treatment involves blocking a pair of proteins that typically limit muscle mass.A SpaceX capsule brought all 40 mice back in good condition, parachuting into the Pacific off the California coast in January. Some of the ordinary mice were injected with the “mighty mice” drug after returning and quickly built up more muscle than their untreated companions, Lee said.The scientists completed the experiment just as the coronavirus was hitting the U.S.“The only silver lining of COVID is that we had time to write it up very intensively” and submit the results for publication, said Dr. Emily Germain-Lee of Connecticut Children’s Medical Center, Lee’s wife who also took part in the study. Both are affiliated with the University of Connecticut.While encouraged by their findings, the couple said much more work needs to be done before testing the drug on people to build up muscle and bone, without serious side effects.“We’re years away. But that’s how everything is when you go from mouse to human studies,” Germain-Lee said.Lee said the experiment pointed out other molecules and signaling pathways worth investigating — “an embarrassment of riches ... so many things we’d like to pursue.” His next step: possibly sending more “mighty mice” to the space station for an even longer stay.Three NASA astronauts looked after the space mice, performing body scans and injections: Christina Koch and Jessica Meir, who performed the first all-female spacewalk last fall, and Andrew Morgan. They are listed as co-authors.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2835

California, get ready for nonstop flights to Hawaii on Southwest Airlines. Southwest Airlines announced on Thursday that four California cities will serve nonstop flights to Daniel K. Inouye International Airport in Honolulu (HNL), Kahului Airport on Maui (OGG), Lihue Airport on Kauai (LIH), and Ellison Onizuka Kona International Airport at Keahole (KOA). Southwest Airlines plans to fly to those Hawaiian cites from Oakland Metropolitan Airport (OAK), San Diego International Airport (SAN), Mineta San Jose International Airport (SJC) and Sacramento International Airport (SMF). The Texas-based airline plans to sell tickets to Hawaii sometime in 2018. The service plans are pending FAA approval.  743

CARLSBAD, Calif. (KGTV) – The Carlsbad Police Department held a community meeting to address a creeper that’s been prowling through neighborhoods.RELATED: Carlsbad Police release sketch of suspected prowler who entered homes on occasionAbout 50 people attended the Thursday night meeting at the Carlsbad Senior Center.Police passed out the sketch of the man they say has been looking through people’s windows and then climbing through the glass.In one case, the prowler climbed into a teenager’s window but ran off when the girl woke up and started screaming.Police say the incidents happened between Sept. 11 and Sept. 16.  In all cases, police say the man went in through an unlocked window on the ground floor. 731

CARLSBAD, Calif. (KGTV) — Prosecutors Wednesday say two transients accused of a deadly home invasion robbery this week stabbed the victim 50 times in the face, neck, and back.Ian Bushee, 37, and Malissa James, 26, are both accused of breaking into a home in the 1800 block of Outrigger Lane just after midnight Monday. During the break-in the victim, identified as 63-year-old Marjorie Gawitt, was stabbed multiple times.Gawitt was still able to call 911 to report the incident and was conscious and breathing when police arrived. She was taken to Scripps La Jolla Hospital, where she died of her injuries.RELATED: Police identify suspects in deadly Carlsbad stabbing, burglaryBushee and James fled the scene in Gawitt's vehicle, according to police. The vehicle was found in San Marcos and the two were arrested in the 4800 block of Park Drive later Monday.Each has been charged with homicide, burglary, conspiracy, and auto theft. Bushee was also charged with accessory after the fact. James also also charged with torture. The pair was already on probation in San Bernardino for residential burglary.Both defendants pleaded not guilty of all charges.Bail was not set for Bushee or James, as they were determined to be a threat to the community.Both face the death penalty. A readiness hearing is scheduled for March 21, and a preliminary hearing is set for March 27. 1377