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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053
SAN DIEGO (KGTV) – James Prince, the owner of a recycling center in Point Loma, went to the Peninsula Community Planning Board Thursday night to try and save his business.Prince Recycling is being evicted from his location on the property of the Stump’s Family Market Place.Prince Recycling has become a controversial business in the past one or two years. It is the only recycling center in the area, but many neighbors have started complaining that it is bringing homeless problems to the area.Dirk Stump, the owner of the grocery store, confirmed he is evicting the recycling center, ending their agreement for the past five years. The area is required to have a recycling center, and Dirk says the state could fine him more than ,000 a year for cutting ties with recycling, but at this point, he is willing to pay, because he says the center is attracting homeless and chasing away customers. He said Mr. Prince is a good person and it was purely a business decision.“I recycle thousands of tons of material, and it’s not just from homeless,” Prince said. “Not only that, they’re people too. What am I supposed to do? You’re homeless you can’t come in?” The planning board did not take any action on the issue. Prince says he’s not making any plans to vacate. He is getting legal help to fight the eviction. 1350

SAN DIEGO (KGTV) – If one of your New Years resolutions was to get out and see more concerts, you've got some great choices to start off the year.Parquet Courts heads to San Diego off their fifth record "Wide Awake!," a punk-funk filled album that's proving to be their most groundbreaking record yet. The band heads to The Music Box.Country Music Hall of Famer and actor Kris Kristofferson and "The Strangers" bring their legendary sounds to the Balboa Theater. Ben and Dana Haggard, sons of country music legend Merle Haggard and accomplished in their own right, lead The Strangers.RELATED: San Diego Restaurant Week 2019: Over 180 restaurants taking partThe six-piece ensemble of Ozomatli also hits Music Box this month with a wide array of musical stylings spanning Latin, funk, jazz, hip-hop, and rock.Sara Dallin and Keren Woodward of the 1980s female English pop group Bananarama are in town to rock The Observatory with their global pop-dance and new wave hits.The legendary Elton John embarks on his farewell tour, stopping in San Diego at Pechanga Arena for what's sure to be an electrifying performance. Fans can undoubtably expect a night with “Bennie and the Jets,” “Rocket Man” and “Crocodile Rock" from the Rock and Roll Hall of Fame inductee.SHOWTIMES:Jan. 21 - Parquet Courts at The Music Box (link)Jan. 22 - Kris Kristofferson & The Strangers at Balboa Theater (link)Jan. 25 - Ozomatli at The Music Box (link)Jan. 27 - Bananarama at The Observatory North Park (link)Jan. 29 - Elton John at Pechanga Arena [formerly San Diego Sports Arena] (link) 1575
SAN DIEGO (KGTV) -- Los Angeles County health officials are scrambling to prevent the spread of hepatitis A after three people became infected with the potentially deadly virus while in San Diego two months ago.In a motion filed by Los Angeles County's Fifth District Supervisor Kathryn Barger, she is asking the Dept. of Public Health to provide a report within 14 days on current efforts to stop an outbreak and a plan for response should one occur."At this time Public Health does not consider there to be a hepatitis A outbreak in Los Angeles County, however it is important that the County proactively educate the community on ways to prevent hepatitis A infection, and have a response plan in the event that the County does see an increase in hepatitis A cases," Barger said in her prevention plan.Citing public health officials, Barger says that the three people who acquired the infection had been in San Diego in mid-July.READ: Most hand sanitizers will not kill Hepatitis A?San Diego County health officials are in the midst of an hepatitis A epidemic with the first cases reported early this year. The virus is known to have sickened at least 421 people and killed 16 in San Diego County.The outbreak started with the homeless and drug using population, according to health officials.Now it has spread to the general population, with nearly 50 documented cases of people becoming sick, who have no ties to homeless or drug users, said the San Diego County Public Health Department.READ:?City opens bathrooms for homeless during hep A crisisCrews are power-washing sidewalks with a bleach solution in East Village downtown.Last week, San Diego county health officials warned customers of a Pacific Beach restaurant that they may have been exposed to a person with hepatitis A on several specific dates and times.San Diego County health officials confirmed the patient worked at World Famous Restaurant while infected. READ: Statement from World Famous RestaurantHepatitis A varies in severity, with mild cases lasting two weeks or less and in more severe cases lasting four to seven weeks or longer. Some individuals, especially children, may not develop jaundice or any symptom at all. However, even mildly ill people can still be highly infectious and should consult a physician, according to County Public Health Officer Dr. Wilma Wooten.Someone with hepatitis can be contagious to others before they develop symptoms, according to the HHSA.READ:?How can you tell if you have hepatitis A? 2569
SAN DIEGO (KGTV) -- In three weeks San Diego County will elect its next district attorney, and in a recent poll a large number of voters indicated that they're still undecided. The results of our scientific 10News Union-Tribune poll shows the battle between Summer Stephan and challenger Genevieve Jones-Wright is wide open. If the election were held today, Summer Stephan would get 35 percent of the vote. Genevieve Jones-Wright would get 22 percent and 43 percent of those polled said they are undecided. "Those polls are consistent with what our campaign research shows," Jones-Wright told 10News. "We knew we were up against a political machine and it really is no surprise to me that she's up on the polls."Progressive candidate Jones-Wright says Stephan got a head start, by being appointed to the district attorney job when Bonnie Dumanis left. Jones-Wright said she thinks the poll shows her campaign is gaining steam.Stephan was encouraged by the poll numbers. "This is very encouraging, what you're telling me, because it shows that what we're doing is working," she told 10News. "That San Diegans are enjoying that we're one of the safest urban regions in the country and that they really prefer experience over an experiment."The poll shows that Stephan's voter base is republican, white and over the age of 35. It shows that Wright's voter base is younger, more racially mixed and primarily democratic. On Monday, Summer Stephan pulled out of a community forum, one which both she and Genevieve Jones-Wright accepted to face off. 1581
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