济南射太快要怎么办(济南总是勃起不够硬怎么办) (今日更新中)

A pinch in the leg, a squeal and a trickle of tears. One baby after another in Malawi is getting the first and only vaccine against malaria, one of history’s deadliest and most stubborn of diseases.The southern African nation is rolling out the shots in an unusual pilot program along with Kenya and Ghana. Unlike established vaccines that offer near-complete protection, this new one is only about 40% effective. But experts say it’s worth a try as progress against malaria stalls: Resistance to treatment is growing and the global drop in cases has leveled off. With the vaccine, the hope is to help small children through the most dangerous period of their lives. Spread by mosquito bites, malaria kills more than 400,000 people every year, two-thirds of them under 5 and most in Africa.Seven-month-old Charity Nangware received a shot on a rainy December day at a health clinic in the town of Migowi. She watched curiously as the needle slid into her thigh, then twisted up her face with a howl.“I’m very excited about this,” said her mother, Esther Gonjani, who herself gets malaria’s aches, chills and fever at least once a year and loses a week of field work when one of her children is ill. “They explained it wasn’t perfect, but I feel secure it will relieve the pain.”There is little escaping malaria -- “malungo” in the local Chichewa language -- especially during the five-month rainy season. Stagnant puddles, where mosquitoes breed, surround the homes of brick and thatch and line the dirt roads through tea plantations or fields of maize and sugar cane. In the village of Tomali, the nearest health clinic is a two-hour bike ride away. The longer it takes to get care, the more dangerous malaria can be. Teams from the clinic offer basic medical care during visits once or twice a month, bringing the malaria shot and other vaccines in portable coolers. Treating malaria takes up a good portion of their time during the rainy season, according to Daisy Chikonde, a local health worker.“If this vaccine works, it will reduce the burden,” she said.Resident Doriga Ephrem proudly said her 5-month-old daughter, Grace, didn’t cry when she got the malaria shot.When she heard about the vaccine, Ephrem said her first thought was “protection is here.” Health workers explained, however, that the vaccine is not meant to replace antimalarial drugs or the insecticide-treated bed net she unfolds every night as the sun sets and mosquitoes rise from the shadows. “We even take our evening meals inside the net to avoid mosquitoes,” she said.It took three decades of research to develop the new vaccine, which works against the most common and deadly of the five parasite species that cause malaria. The parasite’s complex life cycle is a huge challenge. It changes forms in different stages of infection and is far harder to target than germs.“We don’t have any vaccines against parasites in routine use. This is uncharted territory,” said Ashley Birkett, who directs PATH’s Malaria Vaccine Initiative, a nonprofit that helped drugmaker GlaxoSmithKline develop the shot, brand-named Mosquirix. The bite of an infected mosquito sends immature parasites called sporozoites into the bloodstream. If they reach the liver, they’ll mature and multiply before spewing back into the blood to cause malaria’s debilitating symptoms. At that point, treatment requires medicines that kill the parasites.Mosquirix uses a piece of the parasite — a protein found only on sporozoites’ surface — in hopes of blocking the liver stage of infection. When a vaccinated child is bitten, the immune system should recognize the parasite and start making antibodies against it.Scientists also are searching for next-generation alternatives. In the pipeline is an experimental vaccine made of whole malaria parasites dissected from mosquitoes’ salivary glands but weakened so they won’t make people sick. Sanaria Inc. has been testing its vaccine in adults, and is planning a large, late-stage study in Equatorial Guinea’s Bioko Island.And the U.S. National Institutes of Health soon will start initial tests of whether injecting people periodically with lab-made antibodies, rather than depending on the immune system to make them, could offer temporary protection during malaria season. Think of them as “potentially short-term vaccines,” NIH’s Dr. Robert Seder told a recent meeting of the American Society of Tropical Medicine and Hygiene.For now, only babies in parts of Malawi, Kenya and Ghana are eligible for the Mosquirix vaccine. After the vaccine was approved in 2015, the World Health Organization said it first wanted a pilot roll-out to see how well it worked in a few countries — in real-world conditions — before recommending that the vaccine be given more widely across Africa. “Everyone is looking forward to getting it,” said Temwa Mzengeza, who oversees Malawi’s vaccine programs. Those eager for the shots include her husband, whom she had to stop from trying to get them, she said.Mzengeza used to come down with malaria several times a year until she started following her own advice to sleep under a net every night. Unlike many other kinds of infections, people can get malaria repeatedly, building up only a partial immunity.In the pilot program that began last year, 360,000 children in the three countries are meant to be vaccinated annually. The first dose is given at about age 5 months and the final, fourth booster near the child’s second birthday.Experts say it is too early to know how well the vaccine is working. They’re watching for malaria deaths, severe infections and cases of meningitis, something reported during studies but not definitively linked to the vaccine.“To do something completely new for malaria is exciting,” said researcher Don Mathanga, who is leading the evaluation in Malawi. The rainy season has brought new challenges, making some rural roads impassable and complicating efforts to track down children due for a shot. So far in Malawi, the first dose reached about half of the children targeted, about 35,000. That dropped to 26,000 for the second dose and 20,000 for the third. That’s not surprising for a new vaccine, Mzengeza said. “It will pick up with time.”At the health clinic in Migowi in Malawi’s southern highlands, workers see signs of hope. Henry Kadzuwa explains the vaccine to mothers waiting at the clinic. He said there was a drop in malaria cases to 40 in the first five months of the program, compared to 78 in the same period in 2018.Even though he wishes his 3-year-old daughter, Angel, could receive the vaccine, “it’s protecting my community. It also makes my work easier,” Kadzuwa said. The Migowi area has one of the country’s highest rates of malaria, and a worn paper register in the clinic’s laboratory lists scores of cases.At the clinic, Agnes Ngubale said she had malaria several years ago and wants to protect her 6-month-old daughter, Lydia, from the disease.“I want her to be healthy and free,” she said. “I want her to be a doctor.”And she has memorized the time for Lydia’s second dose: “Next month, same date.”___Neergaard reported from Washington.___The Associated Press Health and Science Department receives 7200

A second federal judge has now rebuffed President Donald Trump's sweeping attempt to block House lawmakers from accessing his financial records, handing him another defeat in a fight that has infuriated the President and opened deep rifts with Democrats.Judge Edgardo Ramos in New York on Wednesday refused to block subpoenas from the House Intelligence and Financial Services panels for Trump's financial records from 431

Actor Jussie Smollett will appear in court Thursday for a second time this week after he was indicted on 16 felony counts for allegedly staging a hate crime and filing a false police report.The "Empire" actor, 36, will be arraigned before a judge and enter a formal plea. He was in court Tuesday for a hearing to determine whether a judge should allow cameras in court.His legal team said it welcomes cameras in court due to what it described as "misinformation" leaked to the media since he 504

Actress Jennifer Aniston now holds a world record after her Instagram account was the fastest to gain 1 million followers. After Aniston launched her Instagram account on Tuesday, she attracted 1 million followers in just 5 hours and 16 minutes. According to Guinness World Records, Aniston's record broke a previous record held Prince Harry and Meghan Markle, who gained 1 million followers in 5 hours and 45 minutes. It hasn't taken long for Aniston to gain even more followers. As of Thursday evening, she has already gained 13 million followers. While Aniston has a lot of followers, she is still 173 million followers shy of Cristiano Ronaldo's Instagram account. His account, which has 186 million followers, is the second-most popular account behind Instagram's main account. Aniston's first Instagram photo published on Tuesday was with the rest of the "Friends" cast. The caption read, "And now we’re Instagram FRIENDS too. HI INSTAGRAM." The photo has been liked 13 million times. 1004

A powerful 7.1-magnitude earthquake swayed buildings and cracked streets and foundations in Southern California on Friday night, sending terrified residents into the streets a day after another quake hit.The latest earthquake Friday struck 11 miles northeast of Ridgecrest, according to the US Geological Survey. It was five times bigger and 11 times stronger than Thursday's 6.4 -magnitude earthquake, also centered near Ridgecrest, CNN Meteorologist Brandon Miller said.There's been an average of one aftershock per minute since Friday's quake in the southern part of the state, according to the US Geological Survey website.Gas leaks caused structure fires throughout Ridgecrest, residents reported water main breaks, and power and communications were out in some areas, according to Mark Ghilarducci, director of the Governors' Office of Emergency Management.Several injuries were reported, according to Kern County spokeswoman Megan Person, but Kern County Fire Chief David Witt told reporters there were no known fatalities.About 130 residents from Bakersfield and Trona were staying in a temporary shelter, Person said."On behalf of all Californians, I offer my heartfelt support to those affected by tonight's earthquake near Ridgecrest," Gov. Gavin Newsom said Saturday.The governor said he requested a presidential emergency declaration for assistance.No power or water in San Bernardino townThe San Bernardino County Fire Department said it received multiple reports of damage as well from northwest communities."Homes shifted, foundation cracks, retaining walls down," the department said. "One injury (minor) with firefighters treating patient."Trona, a town of 2,000 people, does not have power or water, San Bernardino County Fire spokesman Jeremy Kern told CNN. Workers had been restoring power from the initial earthquake when Friday's disrupted power again.Both earthquakes disrupted the main water system. Officials are bringing in water to residents and fire teams.No injuries have been reported in the town.'You couldn't stand... without falling over'Ridgecrest resident Jaye Krona said the earthquake felt like her "rocking chair gone crazy.""We had to sit down or crawl on hands and knees to get around because you couldn't stand up and be in an upright position without falling over," Krona said.Krona and her friend Kelly-Jo Lewis spent the night outside on Lewis' driveway."With everything shaking, things are falling. It's just not safe," Lewis said. "I felt safer outside, and I felt me and her were safer together being in pairs."It lasted longer than Thursday's earthquakeBakersfield resident Giovanna Gomez was at home with her family when their house swayed and the water in her pool overflowed. They ran outside."It was about a minute long," she said. "Far larger than the one that (happened) yesterday. It was a smooth roll going back and forth."Bakersfield is in Kern County, about 110 miles from Ridgecrest. Donald Castle, who lives in Porterville, west of Ridgecrest, said his house shook for nearly 25 seconds."It was more of a shake than what we had on the Fourth. It lasted longer and was more rolling," he said.Calls for medical helpNo reports of major gas leaks or serious injuries have been reported, Kern County Fire Chief David Witt said. But calls came in for ambulance and medical assistance.In Los Angeles, about 150 miles south of Ridgecrest, residents felt the earth shake, but no reports of serious damage were made, Mayor Eric Garcetti said.The Los Angeles County Fire Department reported no major damage, deaths or serious injuries, but said some wires were down and power was out in some locations.Shaking felt in Mexico and Las VegasThe shaking was felt as far away as Mexico and Las Vegas, according to the USGS.The NBA Summer League game between the New Orleans Pelicans and the New York Knicks in Las Vegas was postponed Friday following reports of the quake. Scoreboards and speakers near the ceiling of the arena shook when the earthquake hit.Quakes are part of an ongoing systemCalTech seismologist Lucy Jones said Friday both earthquakes are part of an ongoing sequence of a "very energetic system."The latest 7.1-magnitude earthquake was the mainshock, while Thursday's 6.4-magnitude quake was a foreshock, according to Jones.In addition to being bigger, Miller said it released more than 11 times the amount of energy than the 6.4 one.More earthquakes are possible. Newsom said he has activated the state emergency operation center to its highest level."The state is coordinating mutual aid to local first responders," he tweeted Friday night.On Saturday morning, the USGS said the chance of another 7-magnitude or higher earthquake is only 3%-- possible but with a low probability.On the other hand, the chance of a 3-magnitude or higher earthquake hitting the area is over 99%."It is most likely that as few as 240 or as many as 410 such earthquakes may occur in the case that the sequence is re-invigorated by a larger aftershock," the 5016

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