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BEIJING, March 7 (Xinhua) -- The Chinese currency Renminbi (RMB), or the yuan, on Monday strengthened to an all-time high of 6.5651 per U.S. dollar, according to the China Foreign Exchange Trading System.Monday's central parity rate of the RMB against U.S. dollar was 20 basis points lower than the previous record of 6.5671 set on last Friday.The yuan has appreciated 3.84 percent since June 19 last year when the People's Bank of China, the central bank, announced it would further reform the exchange rate formation mechanism to improve its flexibility.On China's foreign exchange spot market, the yuan can rise or fall 0.5 percent from the central parity rate each trading day.The central parity rate of the RMB against the U.S. dollar is based on a weighted average of prices before the opening of the market for each business day.

SHANGHAI, Jan. 29 (Xinhua) -- Three Carrefour stores were fined 500,000 yuan (75,988 U.S. dollars) each on Saturday for overcharging customers in east China's metropolitan Shanghai, said municipal price regulators.The fine is the highest for such wrongdoing, with the tickets being issued Saturday morning.The three stores were also ordered to correct their illegal pricing and refund overcharged customers, said the regulators.A hearing will be held to decide the final amount of the fine. Carrefour representatives will be able to respond to the charges at the hearing, according to regulators.China's price regulator announced last week that it had found several retailers cheating customers, which included 11 of Carrefour's China stores.Carrefour China promised customers Saturday that it would provide refunds of five times the difference between advertised prices and incorrect prices charged at registers, after it was blacklisted by Chinese authorities due to deceptive pricing.Chen Bo, spokesperson with Carrefour China, apologized to Chinese customers during an exclusive interview with Xinhua.Chen said the company has started to work on this pricing issue.Carrefour China has established both short-term and long-term measures to resolve the issue, Chen added."We will have our special control group conduct internal price inspections, with wide coverage and high frequency," Chen said.Chen said the refund policy would be permanently implemented at Carrefour's 182 outlets in China, with non-implementation of the policy being regarded as a violation of company rules.The National Development and Reform Commission, China's top economic planner, also urged authorities to step up price checks ahead of the Spring Festival, which falls on Feb. 3 this year.The Spring Festival holiday is usually the busiest shopping season, as the public makes large purchases of food and gifts for families and friends.

KUALA LUMPUR, Feb. 3 (Xinhua) -- Malaysian Prime Minister Najib Razak wishes all Chinese in the world a happy Chinese New Year on Thursday in an exclusive interview with Xinhua News Agency at his official residence in Federal Administrative Center Putrajaya."I would like to wish all Chinese in the world, wherever they are at any part of the world, a very happy Chinese New Year through Xinhua News Agency,"Najib said. "I hope that this new lunar calendar year, the year of the Rabbit will bring much prosperity and will be a successful and productive year."Najib also noted the 36-year-old special ties between Malaysia and China - a relationship which was first established by his father Abdul Razak, the second prime minister of Malaysia.He stressed that Malaysia is determined to forge closer diplomatic relations with China in years ahead."The relationship between Malaysia and China is a very warm and strong relationship that was established way back in 1974, we were the first Southeast Asian to have established diplomatic relations with China," Najib said."Ever since that historic occasion, the relationship between the tow countries has developed from strength to strength and leaps and bounds and today it's the most important relationship that we have," Najib said. "I hope this relationship will bring much benefit to both Malaysia and China, I wish it can be developed further and strengthen and deepen this important relationship."The prime minister had his Thursday occupied, attending numerous Spring Festival Open House, including the one held by the Malaysian Chinese Association (MCA) - the largest party that represents the ethnic Chinese in the country's ruling coalition.Thousands attended the open house event at the party's headquarters, many of whom were tourists.Malaysian leaders, ambassadors and attaches from foreign embassies were among the invited guests at the event.The Open House is a Malaysian tradition during celebrations where people open their doors to welcome guests and even strangers into their homes.He then held a live teleconference with Malaysians residing in seven cities in the world, including Guangzhou, China, and sent his greetings.About 26 percent of Malaysia's 27 million population are ethnic Chinese.

WASHINGTON, April 6 (Xinhua) -- A study led by researchers at the University of Michigan (U-M) showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppresser function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53."For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.Wang presented the study Wednesday at the American Association for Cancer Research 102nd annual meeting.Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and Sanonfi-Aventis, researchers showed that these new drugs shrank tumors without significant side effects.Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.