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After nearly a decade when US drug overdose death rates were higher in rural parts of the country, drug death rates have shifted to be higher in urban areas, according to a new analysis from the US Centers for Disease Control and Prevention's National Center for Health Statistics.Researchers found that from 1999 through 2003, drug overdose death rates were higher in urban counties than in rural counties. Then, from 2004 through 2006, overdose mortality rates in rural and urban counties were similar. In 2007 through 2015, overdose mortality rates were higher in rural counties than in urban counties. But in 2016 and 2017, urban counties once again had higher rates of drug overdose fatalities.While urban counties had higher rates of overdose deaths involving heroin, cocaine and synthetic opioids such as fentanyl in 2017, rural counties had higher rates of overdose deaths involving prescription opioids such as morphine, codeine, hydrocodone and oxycodone.The overdose death rate related to stimulants such as methamphetamine and amphetamines was 4 per 100,000 in rural counties, higher than the rate of 3.1 per 100,000 in urban counties.In 2017, There were 5.2 heroin-related overdose deaths for every 100,000 people in urban counties, whereas rural counties had a rate of 2.9 heroin-related fatalities for every 100,000 people.In urban counties, the rate of overdose deaths from synthetic opioids such as fentanyl, fentanyl analogs and tramadol was 9.3 per 100,000; and in rural counties that rate was 7 per 100,000. Death rates involving cocaine were also higher in urban counties, with a rate of 4.6 per 100,000, compared to 2.4 per 100,000 in rural counties.But, Dr. Caleb Alexander, co-director of the Center for Drug Safety and Effectiveness at Johns Hopkins, said it was important to not make too much of the distinction between rural and urban areas. "It's important not to lose the forest from the trees here," he wrote in an email to CNN. "Overall the trends and rates are much more similar than they are different between these communities."Alexander noted that the increased overdose rate in urban areas "is attributable to the greater use of heroin and illicit fentanyl in these settings.""The data demonstrate continued increases in mortality through 2017, and they underscore that the epidemic has had a profound impact in rural and urban areas alike," he added.Drug overdose deaths in the United States declined 5.1% in 2018, according to preliminary data released in July by the US Centers for Disease Control and Prevention's National Center for Health Statistics. Researchers estimate there were 68,557 drug overdose deaths in 2018, and 47,590 involved opioids. 2702

A military operation to strike Iran in retaliation for the downing of a US drone was set to begin Thursday night when the White House called it off, a US official with direct knowledge of the matter told CNN. The US military targets were a limited set of Iranian radars and missile batteries, said the official, who spoke on the condition of anonymity because of the sensitivity of the information. No US weapons had been launched when the decision was made to call it off.The-CNN-Wire? & ? 2019 Cable News Network, Inc., a Time Warner Company. All rights reserved. 581

A Wisconsin family is sending out pleas for help after their infant son was told he has just weeks to live without a new liver. Marcus Albers was born in October. His mother says there were complications with his pregnancy but he came out no worse for wear. However, he was diagnosed with Immunodeficiency 47; an extremely rare disorder that attacked his liver. "It's extremely rare," Whitney McLean, the boy's mother said. "From what we've been told, there are 12 cases in the world." Extremely rare but in this family twice. McLean says her two-year-old son Dominic also has the genetic disorder but it's not nearly as severe. "[Dominic] is on the liver transplant list but his condition isn't as critical," McLean said. The family found out about the disorder during the pregnancy with Marcus. McLean found out she was a carrier for the disease and there was no way she could have known because it's only present in boys. "My grandmother had all girls," McLean said. "My mom had all girls and we had two boys. My sister had a baby and it was a girl."Basically, McLean says because she's a carrier, she has one X-chromosome with the disorder and one without. Males have both an X and Y chromosome so she had a 50/50 chance of her son's having the disorder. If she had daughters, her family still wouldn't have any idea. "In the back of our minds, we were concerned of liver issues because of our oldest son," McLean said. "They started taking labs and they started to go in the wrong direction."Marcus' liver began to fail just about three weeks ago. An MRI showed significant liver damage. "We have been here ever since," McLean said. "He's already very resilient. There have been a lot of labs and what he's gone through, I don't think a lot of adults could handle. He's very resilient."McLean knows resiliency in a hospital setting. She's a nurse at Froedtert. So while she's encouraged by his strength at just five-months-old, her experience shows her how dire this situation is. "We were told Marcus has weeks to live and that was a week and a half ago," she said. "So it's pretty dire."That is, unless he gets a liver donation. The liver is one of many organs which can be donated by a living donor. In 2018, there were 36,518 organ donations in the United States. According to the U.S. Government Information on Organ Donation and Transplantation, this included kidneys (21,167), liver (8,250), heart (3,408), lung (2,530), kidney/pancreas (835), pancreas (192), intestine (104) and heart/lung (32).There were only 7,000 live donor transplants last year which accounted for less than 20 percent of all donations. Outside of heart transplants, most other transplants could have used a willing live donor. So more than 90 percent of the 2018 transplants could have potentially used a live donor. Something Marcus' family is praying for. "We don't have a lot of time," McLean said. "We need people who are serious and strict to the criteria. If you are serious and want to help us, we will take the help."The checklist is pretty extensive but not impossible. In order to match with Marcus, a donor needs to be:- In good health- A non-smoker- Under 40-years-old- Under 150 lbs. - O positive or O negative blood 3227

According to multiple reports on social media, an SUV drove through the entrance of the Woodfield Mall near Chicago on Friday.According to local media reports, there is a large police presence at the mall in Schuamburg, Illinois. 242

America's fertility rate and the number of births nationwide are continuing to decline.The number of births for the United States last year dropped to its lowest in about three decades, according to provisional data in a new report from the National Center for Health Statistics at the US Centers for Disease Control and Prevention."Even though the number of births we've seen in 2018 is the lowest that we've seen in 32 years, the total fertility rate is at a record low," said Brady Hamilton, a 509