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WASHINGTON, Dec. 12 (Xinhua) -- British scientists have discovered a new way to target cancer through manipulating a master switch responsible for cancer cell growth. The findings, published Monday in the U.S. journal Cancer Cell, reveal how cancer cells grow faster by producing their own blood vessels.Cancer cells gain the nutrients they need by producing proteins that make blood vessels grow, helping deliver oxygen and sugars to the tumor. These proteins are vascular growth factors like VEGF -- the target for the anti-cancer drug Avastin. Making these proteins requires the slotting together of different parts of genes, a process called splicing.Scientists at the University of West England and the University of Bristol discovered that mutations in one specific cancer gene can control how splicing is balanced, allowing a master switch in the cell to be turned on. This master switch of splicing makes cancer cells grow faster, and blood vessels to grow more quickly, as they alter how VEGFs are put together.In experimental models, the researchers found that by using new drugs that block this master switch they prevented blood vessel growth and stopped the growth of cancers."The research clearly demonstrates that it may be possible to block tumor growth by targeting and manipulating alternative splicing in patients, adding to the increasingly wide armory of potential anti-cancer therapies," the authors said.
BEIJING, Oct. 28 (Xinhuanet) -- Taking aspirin everyday may lower the risk of developing colon cancer for people with the cancer-causing genes, researchers found.The finding was published on Friday in the British medical journal "Lancet".The researchers followed 508 patients with Lynch syndrome, an inherited disorder which increases the risk of developing colon and other cancers.These patients were divided into two groups: members in one group took 600 mg aspirins everyday; another group took only the dummy pills.After 4 years, 10 colon cancer cases were reported among 258 patients who took daily aspirins for at least two years, comparing with 23 cases among 250 patients on dummy pills."This is good news for a very specific population," said Asad Umar, a cancer prevention expert at the U.S. National Cancer Institute.However, the finding doesn't apply to the general public, suggested the lead author of the study John Burn, a geneticist at Newcastle University in England.Only those who are at risk of such diseases should consider taking aspirin regularly, such as people having a family history of colon cancer, he added.
BEIJING, Oct. 20 (Xinhuanet) -- A Teenager's intelligence is not fixed as usually thought. Instead, it can go through swings in a few years, according to a British study reported online in Nature.Teenagers' IQ can rise or fall 20 points over time, researchers from Wellcome Trust Centre for Neuroimaging of Kings College, showed in their study.IQ (short for "intelligent quotient") is an gauge of mental capability measured through a series of standardized tests of language skill, spatial ability, arithmetic, memory and reasoning.To get the findings, Cathy Price, senior researcher of the study, and her colleagues tested 33 British teenagers between the ages of 12 to 16 in 2004, who had average IQ scores around 100. Then the teenagers were retested four years later.The researchers found the volunteers' IQ scores went up and down over the four years, with some teenager's scores rising by as many as 20 points, and others' dropping by the same points."That is quite astounding," cheered psychologist Robert Plomin from the same university but not involved in the study. Dr. Price and her colleagues don't know the causes of such fluctuations in the scores they tested, but speculate that learning experiences might account the changes, reported by the Wall Street Journal Today. "We have to be careful not to write off poorer performers at an early stage when in fact their IQ may improve significantly given a few more years," stated Dr. Price cited by the Huffington Post.
BEIJING, Dec. 31 (Xinhua) -- The Red Cross Society of China (RCSC) has decided to shut down one of its fund-raising groups due to serious management flaws, as the group's alleged misuse of donations sparked public mistrust in charities.The China Business System Red Cross Society has been repealed for failing to establish a sound internal management system, maintaining a benefit-based relationship with a consulting company, and committing violations in financial and legal management, an investigation report said Saturday.The China Business System Red Cross Society, a group founded in 2001 by the China General Chamber of Commerce (CGCC) with the approval of the RCSC, engaged in charity fund raising in the commercial sector. Funds raised by the group are channeled directly to the RCSC.The group faced accusations earlier this year of misusing charity money after a young woman calling herself "Guo Meimei" claimed online to be a general manager of "Red Cross Commerce" and posted pictures on her tweets detailing her lavish lifestyle.Netizens related "Red Cross Commerce" to the China Business System Red Cross Society, and speculated that Guo might have funded her purchases by embezzling money from the Red Cross.In July, the RCSC suspended all operations of the China Business System Red Cross Society and started an investigation along with officials and experts from the Ministry of Supervision, the Chinese Academy of Social Sciences, a law firm and the CGCC.According to the investigation report, "Red Cross Commerce" does not exist, and Guo Meimei is not employed by the China Business System Red Cross Society or its cooperative enterprises.The RCSC says it is preparing to set up a public supervision committee, and it plans to invite people from all walks of life, including influential figures, to supervise its use of donations as a third party.Meanwhile, the RCSC is also building up an online service that will publicize information about all donations made to the Red Cross system nationwide, in a move to safeguard the rights of the public, including donors, and supervise the charity group's operations.The website is expected to be launched by the end of 2012, the RCSC said.The RCSC has also vowed to strengthen the supervision and management of its subsidiaries and promote transparency in donations, financial management, tendering and procurement, and fund distribution and use.
SHIJIAZHUANG, Oct. 16 (Xinhua) -- Chickens began being domesticated in China about 8,000 years ago, far earlier than in the rest of the world,according to a recent study on fossils uncovered in north China's Hebei Province.Archaeologists said they had unearthed 116 fossil specimens from 23 types of animals, including pig, dog, chicken, tortoise, fish, and clam, at the Cishan Site, a Neolithic village relic in the city of Wu'an.Several bone fragments were identified to be from domesticated chickens, said Qiao Dengyun, head of the Handan Municipal Institute of Cultural Relics and Archaeology."The chicken bones found at Cishan are slightly larger than wild jungle fowls, but smaller than that of a modern domesticated chicken," said Qiao.Qiao said the bone fossils date back to 6,000 BC, earlier than the oldest domesticated chicken previously discovered in India that dated back 4,000 years."Most of the bones were from cocks, indicating that ancient residents used the practice of killing cocks for their meat and raising hens for their eggs," said Qiao.The Cishan Site, which dates back 10,000 years, was first discovered in the 1970s. At the site, experts have found remnants of China's oldest cultivated millet as well as walnut shells, a discovery that challenged the popular belief that walnuts had been brought to China from what is now Xinjiang Uygur Autonomous Region and Central Asia.