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JUPITER, Fla. — Groundbreaking research out of the Scripps Research Institute in Jupiter, Florida found a genetic explanation for the pain processing and sensory issues some children living with autism face."To see the biology in the lab turn out that has parallels to what’s going on in these children takes it so far beyond just an academic endeavor," said Dr. Gavin Rumbaugh, a neuroscientist at Scripps. "You go home every day thinking, unbelievably, I may actually be making a difference in someone's life."One of those children who Rumbaugh hopes to help with his research is 10-year-old Beckett, who lives in Texas."We wanted to understand generally in the lab how genes like SYNGAP1 affect the way the brain functions and we thought what better way was then to look and see how this gene may directly affect sensory processing, and then further on ask the question, 'Does the change in sensory processing actually lead directly to learning, memory and behavioral impairment?' " he said.Beckett has a genetic mutation of SYNGAP1, which researchers have now found causes certain issues he faces, particularly, having an extremely high pain threshold while also experiencing heightened sensitivity to another kind of stimuli. Beckett and other children living with this genetic mutation also often have epilepsy."It's all about quality of life. Everybody deserves to live their best life and that's my mission," said Monica Weldon, Beckett's mom.Weldon said the research being done in Jupiter could change her son's life and the lives of hundreds of other children around the world with the same genetic abnormality and symptoms, some of whom whose families she's connected with online."That is the power I believe of a patient group that is motivated to find treatments for their loved ones," Weldon said. "Also, you've got scientists who are listening. They're willing to listen and they're willing to learn."The next step in Rumbaugh's research is to look at treating the symptoms from the genetic mutation. 2043
JCPenney is in serious trouble. There's no sugarcoating it.The department store chain, famous for its Christmas catalogs, is losing money — and customers. It has a lot of debt. And not much cash.A dismal earnings report on Thursday only reinforced that time is running out. JCPenney reported an adjusted loss of million in the first quarter, even worse than Wall Street was expecting, and lowered its projections for the year. Sales fell 4 percent, also missing estimates.Much like floundering rival Sears, JCPenney is struggling to adapt to the changing retail landscape as people increasingly shop on their phones. 628

JACKSON, Miss. — Mississippi legislators have voted to remove a Confederate battle emblem from their state flag. Mississippi’s House and Senate voted Sunday to retire the flag adopted in 1894. It's the last state flag that includes a Confederate symbol that many people condemn as racist. Republican Gov. Tate Reeves has said he will sign the bill. The change comes amid widespread protests over racial injustice. Mississippi has a 38% Black population. A commission would design a new flag that cannot include the Confederate symbol but must have the words “In God We Trust.” Voters will be asked to approve the new design in the Nov. 3 election. 655
JULIAN, Calif. (KGTV) -- More than 1,600 people will be without power in Julian Wednesday as San Diego Gas and Electric crews work to replace equipment. The power company said power will be turned off from noon to 5 p.m. to accommodate the work. “To minimize impact on schools, the planned outage is occurring on a day when schools in the area are scheduled to get out early,” the company said. The company also warned that the work may take longer than expected should any weather conditions or unforeseen events unfold.SDG&E says customers in the area should unplug all sensitive electrical equipment to prepare. Anyone with medical devices that depend on electricity are asked to also contact the company’s Planned Outage Coordinator to make necessary arrangements. Click here for a list of SDG&E outages. 825
JAMUL, Calif. (KGTV) - A Jamul woman whose home was destroyed by the Valley Fire is grateful for the "miracle" just feet from her burned house.Around 4 p.m. Saturday, single mom Kimberlee Jones was with her kids, ages 5 and 3, inside their home on Bunny Drive when she smelled the smoke."The plume was huge, black and brown. The wind was carrying it over the house and I knew we were in big trouble," said Jones.She saw the towering flames a few miles away, as sirens began blaring on her street.RELATED COVERAGEVALLEY FIRE: Resources on where to get help, air quality, and animal sheltersINTERACTIVE MAP: Valley Fire erupts in Japatul Valley areaPhotos: Valley Fire erupts in East County“They’ve asked to make sure that I pin them. And you can buy a new uniform, yeah, but you’d like to wear the one you wore,” he said, holding back tears."The flames seemed like they were walking as they went from one bush to the next. I screamed, ran inside, and grabbed my kids," said a tearful Jones.With no time to take anything, Jones put her kids and their dog in the truck, drove off, and got to safety. About an hour later, she and a friend tried to go back with a trailer for her horses, 11 of them in several outside paddocks. A few miles from her home, she was turned away by deputies. She took a photo of the raging flames, which had moved past her property. She didn't know the fate of home and horses."I just kept praying things would be okay. From the direction of the fire and the winds, I knew we probably would not have a home to go home to," said Jones.A day later, the fears about her home were confirmed. Animal rescue crews, which included a neighbor, snapped a photo of her home of five years, burned to the foundation.RELATED COVERAGE:Red Cross evacuation sites provide outdoor shelter and hotel lodging amid pandemicABC 10News forecast for San Diego County"Felt devastated. There's nothing left," said Jones.But near the ashes, about 50 feet away and not far from some burned fences, a rescuer made a remarkable discovery: The horses were in their paddocks, alive."It's a miracle all of my horses made it out and no worse for wear," said Jones.Jones is now bracing herself for the long road to recovery. She says she will always be grateful."The things I could never replace are alive and well. It's incredible we're all okay," said Jones.A GoFundMe campaign has been set up to help the Jones family with their recovery. 2439
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