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Could the no-calorie sweetener you rely on to replace sugar in your diet actually cause weight gain instead of the weight loss you were expecting?The answer may be yes, according to a new study."Artificial sweeteners are not risk-free," said Brian Hoffmann, assistant professor in the Department of Biomedical Engineering at the Medical College of Wisconsin and Marquette University, and a lead author of the study. "They are a very controversial topic when it comes to health and nutrition ... but they're so prevalent in society that I think we owe it to ourselves to try and figure out what's actually going on."Hoffmann presented his new research Sunday at the annual?Experimental Biology meeting in San Diego. Relying on rats and human cell cultures, his team identified a number of pathways linking artificial sweeteners with metabolic changes at the genetic level that could lead to diabetes and obesity. Specifically, the researchers found that three weeks of exposure to aspartame and acesulfame potassium -- two artificial sweeteners frequently combined in products such as Equal -- altered the expression of certain genes responsible for lipid metabolism in the cells of both rats and humans."Aspartame had some significant changes, and one of those was an increase in lipids in the bloodstream and a decrease in a biomolecule that is involved in clearing (lipids) from the bloodstream. And we saw the exact same thing with the acesulfame potassium," Hoffmann said."We then took those particular sweeteners and put them on endothelial cells -- the cells that line the blood vessels and would be exposed to them in the body -- and we detected a marked dysfunction, suggesting why sweeteners and diet soda have been linked to potential cardiovascular problems," he added.What was perhaps most surprising, according to Hoffmann, was that these metabolic changes did not occur in the presence of natural sugars such as glucose and fructose. This suggests that artificial sweeteners could contribute to metabolic disorders such as diabetes and obesity by an entirely different mechanism than natural sugars, he said.Artificial sweeteners appear to contribute to metabolic disorders by altering the activity of certain genes responsible for the breakdown of macromolecules such as fats and proteins, Hoffmann said. This is different from normal sugars, which contribute to cardiovascular disease through insulin resistance and by damaging the cells lining the body's blood vessels."People are generally consuming non-nutritive sweeteners believing they are a 'healthy choice,' but this may not be true," said research scientist Meghan Azad of the University of Manitoba in Winnipeg, who was not involved in the new study."This is especially important given the widespread and increasing consumption of artificial sweeteners in the general population and the increasing use of artificial sweeteners in our food supply," said Azad, who has authored a paper that reviewed a number of studies on the potential downside of artificial sweeteners on weight and health.According to Azad, over 40% of adult Americans consume no-cal sweeteners on a daily basis, and studies that measure the sweeteners in blood and urine show that many people who report not using artificial sweeteners are unknowingly consuming them.It's the latest assault in the ongoing debate over artificial sweeteners and their impact on health -- a debate that began when one of our most popular foods, sugar, turned sour in terms of health. 3527

Congress passed a bipartisan bill to address the opioid epidemic, and this week the president signed it into law. It's one of the few things that brought Democrats and Republicans together.“Opioids is definitely an issue where there's a lot of bipartisan agreement,” says Republican strategist Brian Bartlett. “We saw the Senate pass their version 99-1. The House also overwhelmingly passed legislation back in June the first time around to address this issue.”Democratic strategist Brandon Neal agrees, saying the issue of opioids is a bipartisan issue affecting everyone.On average, a person dies from an opioid overdose every eight minutes, according to the CDC.“Right now, we're in a point in our society where every average person, everyday person, is affected by this,” Neal says. “So, one pill kills.”The impact of the problem is so big, it forced both political parties to come together to pass a bill that will boost programs to treat addictions, keep a closer eye on prescriptions and promote research to find new drugs that are not as addictive.“I think the next step is to start enacting some of the changes this legislation offered, because in a lot of ways, this was a comprehensive bill, but we need to see what's going to be most effective and what works,” Bartlett says.Just this week, there was a small glimmer of hope. Early data shows the number of overdose deaths are beginning to level off and have even slightly dropped, according to Health and Human Secretary Alex Azar.“The seemingly relentless trend of rising overdose deaths seems to be finally bending in the right direction,” Azar says. 1623

Clinging to notions of widespread vote rigging that his own attorney general has disputed, President Donald Trump repeated a litany of baseless assertions Wednesday of political corruption, machine tampering and mysterious votes appearing out of nowhere that allowed Joe Biden to steal the election.“This election is about great voter fraud, fraud that has never been seen like this before,” Trump said in a 46-minute address posted on social media.“It’s about poll watchers who were not allowed to watch. So illegal. It’s about ballots that poured in and nobody but a few knew where they came from. ... It’s about machinery that was defective, machinery that was stopped.”None of those assertions are true.A look at the claims and reality:VOTER FRAUDTRUMP: “You can’t let another person steal that election from you.”THE FACTS: To be clear, no election was stolen from Trump.One month after the Nov. 3 election and as states begin certifying their votes, Trump is clinging to false notions of voter fraud. But others in his administration have already said the election was secure. Attorney General William Barr said the Justice Department had seen no evidence of widespread fraud to overturn Biden’s margin of victory.Biden earned 306 electoral votes to Trump’s 232, the same margin that Trump had when he beat Hillary Clinton in 2016, which he repeatedly described as a “landslide.” (Trump ended up with 304 electoral votes because two electors defected.) Biden achieved victory by prevailing in key states such as Pennsylvania, Michigan, Wisconsin, Arizona and Georgia.Trump’s allegations of massive voting fraud have been refuted by a variety of judges, state election officials and an arm of his own administration’s Homeland Security Department. Many of his campaign’s lawsuits across the country have been thrown out of court. And his administration has already agreed to allow the formal transition of power to Biden to begin.On Tuesday, Barr told The Associated Press that no proof of widespread voter fraud has been uncovered. “To date, we have not seen fraud on a scale that could have effected a different outcome in the election,” he said.No case has established irregularities of a scale that would change the outcome. Lawsuits that remain do not contain evidence that would flip the result.___BALLOT ‘DUMPING’TRUMP: “I go from winning by a lot to losing a tight race. It’s corrupt.”TRUMP: “It’s about big leads on election night, tremendous leads, leads where I was being congratulated for a decisive, easy victory, and all of a sudden by morning or a couple of days later, those leads rapidly evaporated.”THE FACTS: No mass corruption happened. Trump is actually describing a legitimate vote counting process, not a sudden surge of malfeasance that no one has seen before.Indeed, news organizations and officials had warned in the days and weeks leading up to the election that the results would likely come in just as they did: In-person votes, which tend to be counted more quickly, would likely favor the president, who had spent months warning his supporters to avoid mail-in voting and to vote in person either early or on Election Day.And mail-in ballots, which take longer to count since they must be removed from envelopes and verified before they are counted, would favor Biden. That pattern was exacerbated by the fact that many states prohibited early counting of mail-in votes that arrived before Election Day.In addition, big cities are often slower to report their numbers, and those votes tend to skew Democratic. Likewise, many states tend to count mail-in ballots at the end of the process.___TRUMP: “In Wisconsin, as an example, where we were way up on election night, they ultimately had us miraculously losing by 20,000 votes. And I can show you right here that Wisconsin, we’re leading by a lot, and then at 3:42 in the morning, there was this. It was a massive dump of votes. Mostly Biden.”THE FACTS: No, there wasn’t a “massive dump of votes” in the middle of the night. Milwaukee election officials finished counting the city’s roughly 169,000 absentee ballots around 3 a.m.Wisconsin law requires the results of those absentee ballots be reported all at once. The count of the absentee ballots was livestreamed on YouTube for anyone to watch. When it was finished, Milwaukee police escorted the city’s elections director from a central counting location to the county courthouse to deliver thumb drives with the ballot data.___DOMINIONTRUMP, on Dominion Voting Systems electoral software used in many states: “When you look at who’s running the company, who’s in charge, who owns it — which we don’t know — where are the votes counted — which we think are counted in foreign countries, not in the United States — Dominion is a disaster.”THE FACTS: Servers that run Dominion software are in local election offices, not in foreign countries. Claims that the company has foreign servers or ties to Germany or Venezuela are false.It’s true that the company is privately held and does not disclose its financials, but the New York-based private equity firm Staple Street Capital has owned a majority stake in Dominion since 2018. Fictional claims that Dianne Feinstein, the Clinton family, Nancy Pelosi and Hugo Chavez are owners of Dominion have been debunked.“There is no evidence that any voting system deleted or lost votes, changed votes, or was in any way compromised” in the 2020 election, according to a joint statement released by the federal Cybersecurity and Infrastructure Security Agency.___TRUMP: “In one Michigan county, as an example, that used Dominion systems, they found that nearly 6,000 votes had been wrongly switched from Trump to Biden. And this is just the tip of the iceberg. This is what we caught. How many didn’t we catch?”THE FACTS: That’s a misrepresentation.It’s true that a tabulation problem in the 2020 election involved a few thousand votes in Antrim County, Michigan. But that was the result of human error.When the Republican-leaning county initially reported a landslide win for Biden, social media users grew suspicious about the Dominion election management system used to tabulate the data.It turned out Dominion was not to blame, according to the Michigan Department of State. “There was no malice, no fraud here, just human error,” County Clerk Sheryl Guy told the AP. The tabulation error was corrected.Eddie Perez, a voting technology expert at the OSET Institute, a nonpartisan election technology research and development nonprofit, agreed that the Michigan case was the result of human error involving voting technology, not the software itself.___‘DEAD’ VOTERSTRUMP: “Dead people — and we have many examples — filled out ballots, made applications and then voted.”THE FACTS: He’s repeating a false claim of dead people voting, particularly in Pennsylvania and Michigan. But there’s no evidence that this occurred, and officials in both states say the claims are unfounded.The false claim that deceased voters cast ballots “comes up every election,” said Jason Roberts, a professor of political science at the University of North Carolina at Chapel Hill.Experts told the AP that it is common for state voter rolls to include voters with birthdates that make them appear impossibly old, but these are usually explained by human error, software quirks or voter confidentiality issues.“A similar complaint was brought before a PA court — and soundly rejected,” the Pennsylvania Office of Attorney General said in a statement. “The court found no deficiency in how PA maintains its voter rolls, and there is currently no proof provided that any deceased person has voted in the 2020 election.”Tracy Wimmer, a spokesperson for Michigan’s secretary of state’s office, told the AP that on rare occasions a ballot received from a voter may be recorded as though that person is too old to be alive. This can occur when an incorrect birth year is entered on voter rolls.Some of the claims about dead voters appear to stem from a federal lawsuit that alleges Pennsylvania failed to “maintain accurate and current voter rolls” that include 21,000 apparently deceased registrants. But that is not the same as votes from dead people being cast and counted. The Public Interest Legal Foundation, a conservative group based in Indiana, amended the lawsuit on Nov. 5 against Pennsylvania Secretary of State Kathy Boockvar.The group has taken legal action in a handful of places to try to force voter roll pruning. In December 2019, the group filed a lawsuit against Detroit election officials alleging that the city had over 2,500 dead people on the voter rolls — including one born in 1823. The lawsuit was dropped in June 2020 after election officials updated voter rolls.___POLL WATCHERSTRUMP: “In Pennsylvania, large amounts of mail-in and absentee ballots were processed illegally and in secret in Philadelphia and Allegheny counties without our observers present. They were not allowed to be present. ... They were thrown out of the building.”THE FACTS: He’s incorrect.Trump is wholly misrepresenting a court case in the state and what happened at voting places. No one tried to ban poll watchers representing each side in the election. Democrats did not try to stop Republican representatives from being able to observe the process.The main issue in the case was how close observers representing the parties could get to election workers who were processing mail-in ballots in Philadelphia. Trump’s representatives sued to allow the observers to get closer than the guidelines had allowed. A court ruled in favor of that request.The counting in Philadelphia was being livestreamed, and Trump’s lawyers admitted in court that their campaign had observers in the room — “a nonzero” number of them, as they put it. Poll watchers have no role in counting votes.___Associated Press writers Arijeta Lajka, Michael Balsamo and Colleen Long contributed to this report. 9943

CLEVELAND, Ohio - Students across the nation are still adapting to their new learning environment as more schools have opted to begin the year with remote learning.But, a study from The Rox Institute revealed that girls in middle and high school are struggling significantly. Nearly 1,300 5th-12th grade girls, who attend 88 different schools, completed the survey.The findings show the pandemic has induced stress, feelings of isolation, and depression.Nearly 40% of girls said they had higher stress levels and 80% said they felt isolated more than they had before COVID-19.Clinical psychologist, Dr. Carolyn Levers-Landis said the findings shouldn't come as a surprise."Many are just wondering, "when will this be over? How much longer do I have? Things keep changing," she said. "You just feel like the rug is getting yanked out from under you over and over again."With girls spending less time with family and friends this summer, the survey said they're turning to social media even more. The results show one-third of respondents are spending six or more hours a day on social media.But, the screen time isn't leaving a positive impact. As many spend the time comparing themselves to others."Girls are struggling even without COVID. In a normal world, they're struggling. And then you isolate them and I think it's really hard for them to navigate their new space," said Robyn Cutler.Cutler is the executive director for Girls on the Run Northeast Ohio, an empowerment group for girls with a fitness component. The organization's website said over the course of the ten-week program, girls in 3rd-8th grades develop essential skills to help them navigate their worlds and establish a lifetime appreciation for health and fitness.Cutler said it's okay for girls to be sad about missing their friends, but encouraged parents and caregivers to find ways to tap into their creativity."There isn't enough space in this isolation period for girls to feel like people are listening to them and interacting with them. Parents and caregivers can really do a great job by just making space for them to pay attention to their girl, have conversations with them, read with them," she said.Both Cutler and Dr. Levers-Landis said parents of young girls should be on the lookout for changes in behaviors. Sleeping too much or too little, eating too much or too little, mood swings and less enthusiasm for things that interest them could all be signs of depression.This story was first reported by Meg Shaw at WEWS in Cleveland, Ohio. 2533

CINCINNATI, Ohio — A dozen people connected to various moving companies were indicted in Ohio.The United States Attorney's Office in Cincinnati unsealed an indictment Tuesday that charged the people with conspiring in a racketeering enterprise to defraud customers through their moving companies.WMAR television station in Baltimore, Maryland has reported extensively on the activities of the moving companies. In the last year, they've been connected to four different companies in as many states including Flagship Van Lines, Unified Van Lines, Presidential Moving LLC, and Public Moving Services.The U.S. Attorney's Office has identified more than 900 victims and believes the companies operated in at least 10 states, according to an email sent to WMAR-2 News.A news briefing will be help at 1:30 p.m. Eastern and lives-treamed on WMAR-2 News Facebook.READ MORE:?FBI helping with investigation into Baltimore rogue moving companyREAD MORE: Unlicensed moving company mimics name of reputable Maryland businessREAD MORE: Moving company's license revoked over safety violationsREAD MORE: Complaint-ridden moving company linked to other businesses 1175