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LA JOLLA, Calif. (KGTV) - A researcher at UC San Diego just got a million grant to further his work into nanosponge therapy.Liangfang Zhang, a professor of nanoengineering and bioengineering, has been working on creating macrophage cellular nanosponges, tiny particles covered in white blood cell membranes, to treat sepsis and other diseases."They can be used to bind to the virus and neutralize the virus," Zhang says. "So now the virus would lose the ability to infect the host cells."The nanosponges act as decoys, tricking a disease or virus into binding with them instead of with human cells. While the initial aim is to treat sepsis, Zhang says it has applications to other deadly diseases, including COVID-19."The formulation that we're developing for treatment of Sepsis is the same formulation that you will use with COVID-19," he says.The grant comes from CARB-X, a Boston-based medical philanthropy that specializes in funding research into antibacterial treatments. Zhang says the money will be used for his company, Cellics Therapeutics, to further advance the research into clinical trials, FDA approval, and production of the nanosponge therapy.Steve Chen, president and chief medical officer of Cellics Therapeutics, says he's hopeful they can advance the nanosponges into human trials within two years."We're essentially looking at how this platform can treat not just infectious disease or future pandemics, but you could actually have a lot of applications in any type of autoimmune diseases or any type of inflammatory diseases," says Chen.In an early study published this year, Zhang's research showed the nanosponges were around 90% effective at blocking infections from taking hold.RELATED: UC San Diego researchers testing nanosponges to fight COVID-19Chen says the research and trial period may take too long for the nanosponges to be used during the current coronavirus pandemic. But he's hopeful it will help make the next outbreak less severe."My sincere desire is that we are not going to need this for COVID-19. But I think this does position us very well for any potential future kind of viral outbreak," says Chen.Cellics is also working on a Red Blood Cell version of their nanosponges, which may be ready for human trials within a year. 2283
JACUMBA, Calif. (KGTV) -- Border Patrol and a host of other government agencies are investigating after authorities found a cross-border tunnel in the east San Diego County town of Jacumba.The tunnel was discovered by Mexican State Police on September 19 just 221 feet south of the U.S./Mexico boundary.On October 4, agents found an entry point that was roughly 31 feet deep. The total length of the tunnel is 627 feet, 336 feet of which is in the United States.The average length of the tunnel was three feet high and two and a half feet wide. An exit shaft was discovered, but didn't break the surface into the U.S. RELATED: Cross-border tunnel leading to KFC found in YumaOn top of the massive tunnel, authorities discovered a complex system used to light and ventilate the tunnel. The system included solar panels used to run the electrical, lighting and ventilation systems, and a pump system used to get rid of any water inside the tunnel.Authorities didn’t say whether any arrests have been made or what the tunnel was supposed to be used for, though the Drug Enforcement Administration is one of the investigating agencies. 1149

Kicker Landon White left the Eastern Kentucky University football team while taking a big shot at the program on his way out of the locker room.The Madison Central grad grew disgusted with what he said have been poor, or even nonexistent, safety measures as it relates to the team and its handling of player safety during the COVID-19 pandemic.White claimed in an Instagram post that no one on the team has been tested since July 6. He said symptomatic players are practicing with the team and that positive test results are not being reported.He also accused head coach Walt Wells of being more concerned about the 0,000 payout for playing West Virginia than he is about player safety.LEX 18 has attempted to contact White, but so far has not heard back.Matt Roan, Director of Athletics at Eastern Kentucky University, said in a statement that "egregiously or willfully ignoring safety guidelines, or our established protocol by any of our athletic programs, staff or students is a serious issue and will not be tolerated."Read the full statement below: 1065
Jurors have found Border Patrol Agent Lonnie Swartz not guilty on the Second Degree Murder charge of shooting through the border fence and killing 16-year-old Jose Antonio Elena Rodriguez.Jurors could not come to an agreement on a verdict on the two lesser charges, voluntary manslaughter and involuntary manslaughter.If they wish, prosecutors can retry Swartz on the lesser charges only.Friday jurors told Federal Judge Raner Collins they could not agree on a verdict. The judge told them to continue deliberating. They could choose to convict Swartz on lesser charges of Voluntary Manslaughter or Involuntary Manslaughter.Swartz testified he was protecting himself and other officers from rocks thrown over the border fence by people on the Mexican side trying to interfere with efforts to arrests smugglers who were trying to climb over the fence and into Mexico.In closing statements to the jury, prosecutors said in his two years as a Border Patrol Agent, Swartz had rocks thrown at him six or seven times, and each time had responded by using less lethal weapons. Border Patrol may use items like guns that shoot an irritating pepper.But the night of October 10, 2012, Swartz had been on duty at the DeConcini Port of Entry. He had only his gun and used it to fire 16 rounds through the fence. Ten shots hit the 16-year-old Mexican teen.Prosecutors say the threat against Swartz and other officers was not severe enough to justify deadly force and that they could have easily removed any threat by taking cover.They say other agents took cover but Swartz was fed up with rockings, wanted to send a message, and did it by calmly walking to the border fence, taking careful aim, and firing 16 shots into Mexico.Defense attorney Sean Chapman told the jury rocks are enough of a danger to justify deadly force and that there is no evidence to conclude Swartz fired out of anger over rock attacks. He said jurors should not base their verdict on surveillance video of that night because it is low quality and attempts to enhance it may have altered what it shows.RELATEDTrial beginning for US agent in?cross-border?killing of teenUS agent goes on trial in Mexican teen cross-border killingFederal?judge says border agent's military record off?tableCross-border killing: Should BP Agent's Army AWOL be evidence?Border agent asks?judge?for night border visit by juryJudges?refuses?to oust prosecutors from border shooting caseBP Agent in?cross-border?murder case was forced out of ArmyCross Border?Killing: Prosecutors won't dispute teen was throwing rocksSurveillance disputed in cross-border shooting caseBorder Patrol agent's trial in Mexican killing delayedVigil for Mexican teen killed in border shooting: BP agent charged with his deathBP Agent's murder trial to stay in Federal CourtMurder case against Border Patrol agent to move forwardCross-border killing video challenged 2922
Jared Kushner told a software developer who worked at his newspaper, the New York Observer, to delete several "critical" stories in 2012, according to Austin Smith, the developer who said he "complied."Smith now has regrets about his involvement.Kushner was seeking to erase Observer stories that were "critical of his commercial real estate colleagues," Smith said in a Hacker News message board post.Back then, Kushner was the publisher of the Observer. Now he is a senior adviser to President Donald Trump.Smith said he was inspired to speak out by a recent Hacker News discussion about unethical behavior, plus the president's usage of extreme "enemy of the people" rhetoric to attack journalists."I didn't know any better then, but I do now," Smith said in a series of tweets on Monday.He said he is sorry for deleting stories by Observer staff members.BuzzFeed highlighted the deletions on Monday. A "handful of articles" were affected. The White House press office did not respond to requests for comment.According to emails seen by BuzzFeed's Steven Perlberg, Kushner went around the paper's editors "to mandate the removal of a handful of articles from the website."BuzzFeed noted that "the secret removal of stories due to outside pressure is widely regarded as an unethical practice in journalism."The editor at the time, Elizabeth Spiers, said on Twitter that she found out about this action "a few months ago." Her reaction: "I don't have enough choice expletives describe my feelings about that."How could Kushner pull this off without the newsroom knowing?"When you publish some 50 odd stories a week, you don't notice two or three missing here and there weeks after fact," Spiers told CNNMoney."We also had a couple of site redesigns and site search was abysmal," she added. "So if you didn't immediately find something in search there were more likely (at the time) explanations."Spiers has been critical of Kushner and other Trump White House officials.Kushner resigned from the Observer when he joined the Trump administration in January 2017. He transferred the paper into a family trust. 2116
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