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WASHINGTON, Jan. 19 (Xinhua) -- New research published this week in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs.The study, led by investigators with the Ohio State University Comprehensive Cancer Center, shows that overexpression of two genes called MET and EGFR causes the deregulation of six microRNAs, and that this deregulation leads to gefitinib resistance.The findings support the development of agents that restore the levels of these microRNAs. It offers a new strategy for treating non-small cell lung cancer, which is responsible for about 85 percent of the 221,000 lung-cancer cases and 157,000 deaths that occur annually in the United States. It also suggests that measuring the expression levels of certain microRNAs -- those controlled by the MET gene -- might predict which lung-cancer cases are likely to be resistant to gefitinib.Epidermal growth factor receptor (EGFR) is frequently overexpressed in non-small cell lung cancer, and this leads to uncontrolled cell proliferation. Gefitinib selectively inhibits EGFR activation and triggers cancer cells to self-destruct by apoptosis. However, non-small cell lung cancer cells inevitably develop resistance to the drug. The study reveals how this resistance occurs."Our findings suggest that gefitinib resistance that is caused by MET overexpression is at least partly due to miRNA deregulation, " says principal investigator Carlo Croce.

SAN FRANCISCO, Nov. 21 (Xinhua) -- Hewlett-Packard Co. (HP) on Monday reported that its profit in the most recent quarter fell more than 90 percent with sales also declining.In the company's fourth quarter of fiscal 2011 ended Oct. 31, the company posted net earnings of 239 million U.S. dollars, compared with 2.54 billion dollars in the same period a year earlier.HP's net revenue for the quarter reached 32.1 billion dollars, down 3 percent year-on-year.Excluding one-time items, HP earned 1.17 dollars per share, which topped estimates of analysts.According to Thomson Reuters, analysts had expected earnings of 1.13 dollars per share on revenue of 32.05 billion dollars.It was the first earnings report since Meg Whitman took over as chief executive officer (CEO) of the information technology giant on Sept. 22, replacing Leo Apotheker."HP has a great opportunity to build on our strong hardware, software, and services franchises with leading market positions, customer relationships, and intellectual property," Whitman said in a statement after the earnings announcement."We need to get back to the business fundamentals in fiscal 2012, including making prudent investments in the business and driving more consistent execution," she added.

JERUSALEM, Dec. 11 (Xinhua) -- Kfir Damari, a communication systems engineer, has a dream: to land a miniature spacecraft on the moon sometime in 2013.Damari is one of the founders of Team SpaceIL, a non-profit organization representing Israel in the Google Lunar X Competition. The prize: 20 million U.S. dollars to the first of the 26 international teams currently registered that lands an unmanned craft on the moon, moves it a minimum of 500 meters across the lunar surface and transmits live high-resolution images back to earth."It's a tough mission, but I believe that if everyone in Israel joins hands it's possible," Damari told Xinhua.It is exactly the kind of entrepreneurial spirit that Israel, a country largely void of natural resources, counts on to make it a global leader in technological innovation.The two other men behind the initiative are Yonatan Winetraub, 25, a systems engineer at Israel Aerospace Industries (IAI) and a graduate of NASA's International Space University, and Yariv Bash, 31, a computer scientist and electronics engineer. The three first met at an innovation conference held by IAI a year ago.They describe the lander as a nano-satellite, whose design was revealed at the project's official inauguration ceremony on Thursday. The vessel weighs 100 kg, 80 percent of which are fuel, and is outfitted with rocket boosters and a panoramic camera."It's somewhat of a cellular phone sitting on a large fuel tank. All the technology that we require is basically contained in a typical smartphone with its communication and imaging features," Damari said.Launched in 2007, the Lunar X Prize aims to encourage space enthusiasts and engineers worldwide to develop cheap technologies for robotic space exploration.The Israelis have slated a modest 15 million U.S. dollars for the endeavor, 90 percent of which must come from private contributions according to the competition's rules. They have already raised 3.5 million dollars.The fact that they have formed a non-profit NGO in itself is worthy of praise. Most other teams have obtained the patronage of private corporations for whom money is not a problem, with some reportedly allotting up to 100 million U.S. dollars.To compensate for the disparities in funding, Damari and his partners have enlisted the support of 120 local volunteers, many of them engineers holding top positions in the technological and scientific community as well as the country's leading defense industries.Rona Ramon, the widow of Israeli astronaut Ilan Ramon killed aboard the Columbia Space Shuttle in 2003, was one of the sponsors too.In a bid to keep costs down, SpaceIL is heavily relying on the existing knowledge accumulated by Israel's defense industries over the past decades in building and launching mainly small, lightweight communications and military surveillance satellites into space.The challenge, Damari said, is to take that know-how a step further. The professionals who have volunteered for the project, among them some of Israel's most revered space experts, are currently grappling with several issues, including the ignition system, optic-visual navigation, beaming imagery to earth and the intricacies of enabling the nano-satellite a smooth lunar landing.SpaceIL is still searching for a third party that they will lease to launch their vehicle into space. Once there, they will have to navigate it to the moon on their own.While 20 million U.S. dollars is a major motivator for anyone, the Israelis said they're not seeking personal gain, but rather plan to invest the prize money in the vision that originally prompted their registration in December last year: inspiring the country's younger generation to pursue engineering and the sciences and to dream big, just like Neil Armstrong did when he disembarked from the Apollo 11 and took the first step on the moon in 1969.The funds, they said, will be funneled to educational programs that seek to rejuvenate youths' interest in science disciplines, which have been on the decline in the country's high schools in recent decades."We hope to attract the next generation of kids, to enable them to be engineers and scientists and to make sure that we have more people that can build spaceships in Israel in the future," said Damari.He and the other men behind the initiative also acknowledge that their motives are no less driven by patriotism. Winning the Lunar X has the potential to create national pride and put Israel "on the map as a start-up nation" by accomplishing a feat reserved for superpowers."The moon is something you see every day. I think that for me personally, space exploration is the way to enlist the nation to do something that has not yet been done," said Damari, who started programming aged six and wrote his first computer virus aged 11."It's also about exploring new borders, going the distance. (The project) will leverage Israel's space industry. I'm sure that all the industries that will partner with us will learn a lot and develop new applications, especially for the civilian market," he said.On Thursday, Israeli President Shimon Peres, whose name has become synonymous with the nation's hi-tech industries, honored the trio by unveiling their model at the ceremony held at MABAT -- IAI's missiles and space division near Tel Aviv."More than Israel is leading technology, it is likely to lead Israel. It's the key to our economy ... If they win the prize, and I'm sure they will, it will also reward Israel with the deepest appreciation and the best deterrence," Peres told a crowd of senior executives from local defense industries."I admire your audacity and vision," he complimented the three scientists.Will they realize their ambition? Damari expressed humble optimism, "It's not easy, but certainly possible ... We believe we can win."

NANCHANG, Oct. 1 (Xinhua) -- A copper sword dating back more than 2,200 years has been discovered in east China's Jiangxi Province, local archaeologists said.The design and shape of the sword indicate that it was forged during the Warring States Period (475 BC - 221 BC), according to Li Guoli, curator of the Nanchang Museum, where the sword is currently being stored.Despite having little aesthetic or scientific value due to a lack of decor or inscriptions, the sword still offers insights into the type of military equipment used during the period, Li said.The identity of the sword's original owner and the precise location where the sword was forged and used are still unknown, Li said.The sword was discovered by a laborer surnamed Xiong in Jiangxi's capital of Nanchang. Xiong found the sword while sorting and cleaning stones that had been dredged up from a riverbank.An argument between Xiong and another worker who was trying to claim the sword aroused attention from the local law enforcement, who then convinced Xiong to turn the sword over to archaeological authorities.

BEIJING, Nov. 24 (Xinhua) -- China's Supreme People's Court vowed to harshly crack down on bribery, abuse of power and malpractice in food safety cases as such illegalities have become top concerns for Chinese people.Chinese courts at all levels had heard 173 cases and sentenced 255 people in relation to the production and sale of unsafe food in the first ten months of this year, Sun Jungong, spokesman of the Supreme People's Court (SPC), said Thursday."China has seen a growing number of food safety cases in recent years with increasing difficulties for investigation," Sun said.According to the SPC, Chinese courts handled 84 food safety cases in 2008, and 148 and 119 cases in 2009 and 2010, respectively. The number of food safety violators sentenced in the past three years totaled 101, 208 and 162, respectively.The SPC also promulgated four typical food safety illegalities exposed in recent years.In the latest food safety scandal, four people in central China's Henan province were prosecuted for the crime of "endangering public security by using dangerous means" in July after they were found to have produced and sold clenbuterol, a poisonous feed additive that pig farms use to boost the output of lean meat.The spokesman said the SPC will strengthen cooperation with police and procuratorial organs to improve the efficiency of dealing with, and preventing food safety crimes.

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