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LONDON (AP) — Oxford University says trials of a coronavirus vaccine that it is developing with pharmaceutical company AstraZeneca will resume, days after being paused due to a reported side-effect in a patient in the U.K. The university said in large trials such as this “it is expected that some participants will become unwell and every case must be carefully evaluated to ensure careful assessment of safety.” It said globally 18,000 people have received the vaccine so far. Oxford insisted that it is “committed to the safety of our participants.” Pauses in drug trials are commonplace. The Oxford-AstraZeneca vaccine is seen as one of the strongest contenders among the dozens of coronavirus vaccines being tested. 728
LOS ANGELES (AP) — Georgia Engel, who played the charmingly innocent, small-voiced Georgette on "The Mary Tyler Moore Show" and amassed a string of other TV and stage credits, has died. She was 70.Engel died Friday in Princeton, New Jersey, said her friend and executor, John Quilty. The cause of death was unknown because she was a Christian Scientist and didn't see doctors, Quilty said Monday.Engel was best known for her role as Georgette on "The Mary Tyler Moore Show," whose character was improbably destined to marry pompous anchorman Ted Baxter, played by Ted Knight.Engel also had recurring roles on "Everybody Loves Raymond" and "Hot in Cleveland." She was a five-time Emmy nominee, receiving two nods for the late Moore's show and three for "Everybody Loves Raymond."Engel's prolific career included guest appearances on a variety of shows, including "The Love Boat," ''Fantasy Island," ''Coach" and "Two and a Half Men." Her "Hot in Cleveland" role reunited her with Betty White, her co-star in "The Mary Tyler Moore Show."She appeared on Broadway in plays and musicals including "Hello, Dolly!", "The Boys from Syracuse" and, most recently, "The Drowsey Chaperone" in 2006-07.Engel's final credited television appearance came last year in the Netflix series "One Day at a Time." 1299

LOS ANGELES (AP) — After weeks of stressing education over enforcement, California communities are issuing fines and relying on anonymous tips to make sure businesses and residents are complying with health orders amid the coronavirus pandemic. Los Angeles County, the state’s most populous, is averaging 2,000 reports a week on its tip lines with complaints ranging from a lack of hand sanitizer to improper cleaning of workplace bathrooms. California on Thursday reported nearly a half-million confirmed virus cases since March, the most in the nation, and 391 deaths were tallied over the last two days, the highest since the start of the pandemic. 659
LOS ANGELES (CNS) - Three men were named Wednesday in a Los Angeles federal grand jury indictment that alleges they distributed narcotics, including counterfeit pharmaceutical pills containing fentanyl, that resulted in the overdose death of hip-hop artist Mac Miller.Cameron James Pettit, 28, of West Hollywood; Stephen Andrew Walter, 46, of Westwood; and Ryan Michael Reavis, 36, a former West Los Angeles resident who relocated to Lake Havasu, Arizona, earlier this year, are charged with conspiring to distribute controlled substances resulting in death and distribution of fentanyl resulting in death.Each of those counts carries a mandatory minimum sentence of 20 years in federal prison and a potential sentence of life without parole, according to the U.S. Attorney's Office.Walter alone is additonally charged with being a felon in possession of ammunition, which, if he were to be convicted, would result in a sentence of up to 10 years in federal prison.Court documents allege the three defendants distributed narcotics to 26-year-old Malcolm James McCormick -- who recorded and performed under the name Mac Miller -- two days before the entertainer suffered a fatal drug overdose in Studio City on Sept. 7, 2018.The Los Angeles County Medical Examiner-Coroner later determined that Miller died of mixed drug toxicity involving fentanyl, cocaine and alcohol.According to the indictment, late on the night of Sept. 4, Pettit agreed to supply the rapper with 10 ``blues'' -- a street term for oxycodone pills -- as well as cocaine and the sedative Xanax. But instead of providing Miller with genuine oxycodone when he made the delivery during the early morning hours of Sept. 5, Pettit provided counterfeit oxycodone pills that contained fentanyl -- a powerful synthetic opioid that is 50 times more potent than heroin, according to the indictment.The indictment alleges that Pettit ordered the fentanyl-laced pills from Walter, and then Reavis delivered the narcotics to Pettit. Investigators believe that Miller died after snorting the counterfeit oxycodone pills containing fentanyl allegedly provided by Pettit. While another individual supplied Miller with other drugs prior to his death, those narcotics did not contain fentanyl, prosecutors said.Less than one month after Miller's death, Walter agreed to sell Pettit another 10 blues, according to the indictment, which also alleges other drug deals between the two men, with one as recent as Aug. 30. The indictment further alleges that Reavis was involved in drug trafficking activities in June and quotes a text message he sent after realizing he was negotiating a narcotics transaction with an unknown person that reads, in part: ``People have been dying from fake blues left and right, you better believe law enforcement is using informants and undercover to buy them on the street ... they can start putting (people) in prison for life for selling fake pills.''U.S. Attorney Nick Hanna said it has become ``increasingly common for us to see drug dealers peddling counterfeit pharmaceuticals made with fentanyl. As a consequence, fentanyl is now the number one cause of overdose deaths in the United States.''Hanna alleged that the three defendants continued to sell narcotics after Miller's death, ``with full knowledge of the risks their products posed to human life.''Special Agent in Charge William D. Bodner of the Drug Enforcement Administration's Los Angeles Field Division warned that counterfeit pharmaceutical pills are especially dangerous because users are unable to verify what they are ingesting.``The tragic death of Mac Miller is a high-profile example of the tragedy that is occurring on the streets of America every day,'' Bodner said, adding that the indictment ``highlights the efforts of DEA agents, local law enforcement officers, and prosecutors who work tirelessly to bring dangerous drug dealers to justice.''Pettit, who was previously ordered detained after being charged in a criminal complaint with distributing narcotics to McCormick, is scheduled to be arraigned in downtown Los Angeles on the indictment on Oct. 10.Walter was arrested on Sept. 23 on a criminal complaint alleging conspiracy to distribution narcotics, and he was also ordered held without bond. Walter also is scheduled to be arraigned on the indictment Oct. 10.Reavis, who was taken into federal custody in Arizona on Sept. 26 on charges of being a felon in possession of a firearm, is currently in custody and is being transported to Los Angeles by the U.S. Marshals Service. 4553
LOS ANGELES (CNS) - A pair of active-duty U.S. Marines stationed at Camp Pendleton were arrested Tuesday morning on a federal grand jury indictment charging one of the Marines and three civilians with conspiring to distribute narcotics -- including oxycodone pills laced with fentanyl -- to civilians and members of the Marine Corps, one of whom suffered a fatal drug overdose in May.Lance Cpls. Anthony Ruben Whisenant, 20, and Ryan Douglas White, 22, were expected to make their initial appearances Tuesday afternoon in U.S. District Court in Los Angeles. Whisenant allegedly distributed narcotics to fellow Marines, including the one who overdosed, and White is charged with being an accessory after the fact for allegedly attempting to hinder the apprehension of Whisenant and an alleged drug supplier named in the indictment.The 14-count superseding indictment also charges:-- Jordan Nicholas McCormick, 26, of Palmdale, the lead defendant and the conspiracy's alleged supplier of LSD, ecstasy, cocaine and oxycodone pills laced with fentanyl to co-conspirators-- Gustavo Jaciel Solis, 24, of Sylmar, who allegedly distributed McCormick's drugs to civilians and military personnel-- Jessica Sarah Perez, 23, of Pacoima, who allegedly distributed narcotics, including fentanyl and cocaine, to civilian customersOn Aug. 11, Solis and Perez were indicted on fentanyl and cocaine distribution charges, and Solis was indicted on firearms-related charges. They have pleaded not guilty and their trial date is scheduled for Oct. 27. Solis is in federal custody and Perez is free on ,000 bond.Tuesday's updated indictment adds McCormick -- who is also in federal custody -- Whisenant and White as defendants, in addition to adding charges to the original indictment. According to the indictment, the conspiracy lasted from last November through this month and involved multiple sales of fentanyl- laced oxycodone to an undercover buyer, often for amounts exceeding ,000 per buy.On May 22, Solis sold 10 pills of oxycodone laced with fentanyl to an active-duty Marine who died of a drug overdose in the early morning hours of May 23, the indictment alleges.In addition to the conspiracy charge, McCormick, Solis, Whisenant and Perez face substantive charges of distribution of narcotics, including fentanyl. McCormick and Solis are also charged with possessing firearms in furtherance of drug crimes.If convicted, McCormick and Solis would face a sentence of 10 years to life in federal prison, and Whisenant and Perez would each face up to 20 years behind bars. White, if convicted, would face up to 10 years in federal prison. 2637
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