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At least 285 U.S. children have developed a serious inflammatory condition linked to the coronavirus and while most recovered, the potential for long-term or permanent damage is unknown, two new studies suggest.The papers, published online Monday in the New England Journal of Medicine, provide the fullest report yet on the condition.The condition is known as multisystem inflammatory syndrome in children. It is considered uncommon and deaths are rare; six children died among the 285 in the new studies.Including cases in Europe, where it was first reported, about 1,000 children worldwide have been affected, a journal editorial said.The federal Centers for Disease Control and Prevention’s case definition includes current or recent COVID-19 infection or exposure to the virus; a fever of at least 100.4 for at least 24 hours; severe illness requiring hospitalization; inflammatory markers in blood tests, and evidence of problems affecting at least two organs that could include the heart, kidneys, lungs, skin or other nervous system.Digestive symptoms including nausea and diarrhea are common. Some children may have symptoms resembling Kawasaki disease, a rare condition in children that can cause swelling and heart problems.At least 35 states have had cases, and they seem to crop up a few weeks after local COVID-19 activity peaks, said Dr. Adrienne Randolph of Boston Children’s Hospital. She is a lead researcher for a multistate study that includes CDC scientists. The second paper involved 99 children in New York state, where the first U.S. cases occurred.Combined, the papers show 285 cases from March thru mid to late May but Randolph said additional U.S. children have been diagnosed in June.Most had current or recent COVID-19 infections but had previously been healthy.About 80% of children in the multistate study had heart-related problems, which included coronary aneurysms — a bulge in a heart artery that can be fatal.“Those need to be followed up,” Randolph said. “This is a life-threatening concern for a lot of patients.”Most affected children had no other health condition but about 30% were obese. The condition also appears to disproportionately affect Latino and Black children and boys.The average age was 8 years old. Researchers don’t know if adults can be affected.___Follow AP Medical Writer Lindsey Tanner at @LindseyTanner.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. (hyperlink ‘support’ with this: http://bit.ly/2ptoKnW 2618

At a White House news conference on Friday, leaders of Operation Warp Speed said that two coronavirus vaccines could receive emergency use authorization from the FDA in the coming weeks.In addition, Dr. Moncef Slaoui, who is the scientific head of Operation Warp Speed, projected that up to 20 million coronavirus vaccines could be shipped by the end of the year."If approved, they could be used for immunization in the U.S. population in the month of December," Slaoui said. "And we plan to have enough vaccine doses available for use in the U.S. population to immunize about 20 million individuals in the month of December, and another 25 to 30 million per month on an ongoing basis thereon."Given that doses of the two vaccines come in two doses, it could take many months and be well into 2021 before the majority of the American population is vaccinated against the coronavirus.The update came as the virus spreads throughout the country at an alarming and uncontrolled rate. At least 100,000 Americans are confirmed to have contracted the virus every day for the last 10 days, culminating in a record-shattering 153,000 cases on Thursday. Hospitalizations linked to the virus have reached all-time highs since the pandemic began, and deaths linked to the virus are beginning to tick up as well.The update also comes days after Pfizer announced that its vaccine candidate has been 90% effective in Phase 3 trials. The company says it is on track to apply for Emergency Use Status by the end of the month, meaning that some Americans could receive the vaccine before the year's end.New York Gov. Andrew Cuomo, who said his state would independently review vaccine candidates before authorizing distribution to the state, was a frequent target during Friday’s news briefing.“Vaccines will be allocated pro rata by population so we ensure fair and equitable across. We need the states who are part of the planning to accept the vaccine,” saidArmy General Gustave F. Perna, who is overseeing logistics and distribution for Operation Warp Speed. “We are working closely along with the CDC, the jurisdictions and states to ensure vaccine can safely and quickly get to those who need it first.”Trump blasted Cuomo for utilizing an independent review process separate from the FDA. "We won't be delivering it to New York until we have authorization to do so," Trump said. "That pains me to say that. This is a very successful, amazing vaccine that 90% or more. The governor, Gov. Cuomo will have to let us know when he's ready for it. Otherwise, we can't be delivering it to a state that won't be giving it to its people immediately. I know the people of New York very well, I know they want it. The governor will let us know when he's ready."Pfizer said it expects to have 50 million doses of its vaccine ready for global distribution by the end of 2020, and 1 billion doses globally by the end of 2021. That's why other vaccines are also being looked in hopes of getting as many Americans vaccinated as soon as possible. Trump and others on Operation Warp Speed confirmed that health care workers and the elderly would be first to receive doses of the vaccine. Dr. Anthony Fauci, the Trump administration's top infectious disease expert, predicted earlier this week that the vaccine would be widely available in April.Previously, Trump had suggested that a vaccine would have been approved in October and widely available by the start of 2021. Project Warp Speed leaders, however, credited the federal government's response to the virus even if the vaccine has not been distributed as quickly as previously suggested.Friday's remarks were Trump's first on-camera comments since Joe Biden was projected as the winner of the presidential election. Trump had not delivered comments to the press on-camera since Nov. 5, when at a press conference in the White House press room he falsely claimed he would win the presidential election on still-baseless claims of widespread voter fraud.Trump has appeared on camera just once in the last week — a Veteran's Day appearance at Arlington National Cemetery at which he did not speak.Trump's extended media blackout is out of step with the first four years of his administration. Trump has rarely shied away from speaking with reporters, as he often makes himself available for on-camera interviews with the White House press pool on the front lawn and has taken to calling friendly media outlets for phone interviews.However, since last Thursday, Trump has only delivered statements through his Twitter account, where he has continued to spread misinformation about the 2020 election. In the past week, Twitter has taken action on about 50 of Trump's tweets or retweets — be it adding a link to more information, adding a fact check or hiding the tweet from timelines completely. 4827

At Uptown Wines, Beer & Spirits, sales have surged since the COVID-19 crisis started and are expected to rise even more during the holidays.“Last time I’ve seen sales like this, it would be considered New Year’s, Thanksgiving and Halloween night,” said beer specialist Wiley Deerman.Deerman says with more people quarantined at home many started stocking up on alcohol to-go.“We’ve seen a lot of these half-sized bottles, the sales have increased on those,” he said.Now, new research from Vanderbilt University shows not only are more people drinking alcohol and abusing other drugs during the pandemic, but that this increase could create new addicts as well.“You’re seeing an increase in drinking, in drug use in people at home. When the pandemic’s over, this isn’t going to go away," said Erin Calipari, Ph.D., with the Vanderbilt Center for Addiction Research.Calipari’s team conducted the study, which shows addiction triggers during the COVID-19 crisis could make the holiday season even worse for many adults struggling with sobriety.To help fight this problem, Calipari says America needs the same kind of investment in battling addiction as is being put into solving the pandemic.“Addiction kills just as many people as the pandemic has this year and we haven’t done the same thing,” she said. “We’ve kind of, you know, funded it a little bit but we haven’t had this community investment and this kind of global revelation that this is a problem that we should be solving.”Without proper attention, Calipari predicts addiction cases will continue to increase across the country, even after there’s a cure for COVID-19.“This isn’t going to go away when we get the vaccine or solve the pandemic,” she said. “This is going to be a kind of long-term problem that we’re going to have to deal with as a society.”A very costly problem both in money and human lives.That’s why Deerman’s business focuses on more than making a buck, saying the best way to serve his community is to sometimes actually not serve them at all.“There’s times where we have to say, ‘Look, I think you need to cut back, take it easy. we care about you,’” he said.Care about stopping an addiction before it even starts. 2203

As the debate over guns continues in Washington and in communities across the country, there's at least one place where owning a gun is technically required by law.In Kennesaw, Georgia, local law says that "every head of household residing in the city limits is required to maintain a firearm.""If you're going to commit a crime in Kennesaw and you're the criminal -- are you going to take a chance that that homeowner is a law-abiding citizen?" asked Kennesaw Mayor Derek Easterling.Wayne Arnold is one of those citizens. Among the weapons he keeps at home are an AR-15-style .223 caliber rifle, a variety of handguns and more."It gives me the ability to protect myself as opposed to being somewhere where you weren't allowed to have a firearm or it was frowned upon," said Arnold."More or less a political statement" 826

As Meryl Streep, Daniel Kaluuya and Mary J. Blige ready themselves for this Sunday's Academy Awards ceremony, millions of movie fans are waiting to see who will take home those coveted gold statues.Win or lose, the locations where those Best Picture nominees were filmed -- think North Carolina's Blue Ridge Mountains for Ebbing, Missouri; Sacramento for "Ladybird" -- may become as famous as the actors who starred in them.But often, much of the magic is created in the studio. Fortunately, there are excellent museums and studio tours that allow film fans to get a taste of the magic that is the movies. Here are eight of our favorites.The Making of Harry Potter, London, United Kingdom 696