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LOS ANGELES (AP) — More than 325,000 doses of a COVID-19 vaccine are on their way to California on Sunday amid record-setting case numbers and shrinking intensive care unit capacity. The first shipments of the Pfizer vaccine left Michigan early Sunday. States will get vaccines based on their adult population and additional shipments are coming this week.In California, counties will have specific allotments that will be distributed to hospitals determined by state health officials to have adequate storage capacity, serve a high-risk health care population and have the ability to vaccinate people quickly. Priority will be to inoculate health care workers. 669

LOS ANGELES (CNS) - USC researchers have found the likely order in which COVID-19 symptoms first appear: fever, then cough and muscle pain, followed by nausea, and/or vomiting, and diarrhea, it was announced Thursday.Knowing the order of COVID-19's symptoms may help patients seek care promptly or decide sooner than later to self isolate, according to scientists at the USC Michelson Center for Convergent Bioscience. The information also may help doctors rule out other illnesses, or help doctors plan how to treat patients, and perhaps intervene earlier in the disease.The study, which appears in the journal Frontiers in Public Health, was led by doctoral candidate Joseph Larsen and scientists Peter Kuhn and James Hicks at the USC Michelson Center's Convergent Science Institute in Cancer."This order is especially important to know when we have overlapping cycles of illnesses like the flu that coincide with infections of COVID-19," said Kuhn, a USC professor of medicine, biomedical engineering, and aerospace and mechanical engineering. "Doctors can determine what steps to take to care for the patient, and they may prevent the patient's condition from worsening."Fever and cough are frequently associated with a variety of respiratory illnesses, including influenza, Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome. But the timing and symptoms in the upper and lower gastrointestinal tract set COVID-19 apart."Given that there are now better approaches to treatments for COVID- 19, identifying patients earlier could reduce hospitalization time," Larsen said.To determine COVID symptom chronology, the authors analyzed more than 55,000 confirmed coronavirus cases in China collected from Feb. 16 to Feb. 24 by the World Health Organization. They also studied a dataset of nearly 1,100 cases collected from Dec. 11 through Jan. 29 by the China Medical Treatment Expert Group via the National Health Commission of China.In addition, to compare the order of COVID-19 symptoms to influenza, the researchers examined data from 2,470 cases in North America, Europe and the Southern Hemisphere, which were reported to health authorities from 1994 to 1998."The order of the symptoms matter, " Larsen said. "Knowing that each illness progresses differently means that doctors can identify sooner whether someone likely has COVID-19, or another illness, which can help them make better treatment decisions." 2440

LOS ANGELES (AP) — Officials say a Northern California county has begun a door-to-door coronavirus testing pilot program in a majority Latino community that has become a virus hot spot. Santa Clara County volunteers started handing out self-testing kits in the East San Jose neighborhood of Silicon Valley’s San Jose last week, where 55% of the population is Latino and officials say many residents do not have the ability or means to get tested. Communities of color nationwide have been disproportionately affected by the virus. Santa Clara County’s efforts come as more than 325,000 doses of a COVID-19 vaccine are on their way to California on Sunday amid record-setting case numbers and shrinking intensive care unit capacity. 739

LOS ANGELES (AP) — A technical problem has caused a lag in California’s tally of coronavirus test results, casting doubt on the accuracy of recent data showing improvements in the infection rate and hindering efforts to track the spread. State Health and Human Services Secretary Dr. Mark Ghaly said Tuesday that in recent days California has not been receiving a full count through electronic lab reports because of the unresolved issue. The state’s data page now carries a disclaimer saying the numbers represent an underreporting of actual positive cases per day. The latest daily tally posted Tuesday showed 4,526 new confirmed positives, the lowest in more than six weeks. 685

LOS ANGELES (AP) — Hard-hit California has eclipsed 2 million coronavirus cases as the U.S. heads into a Christmas travel surge that could fuel the deadly crisis across the nation. Over 1.19 million travelers passed through the nation’s airport security checkpoints Wednesday. Airports also recorded around 1 million travelers on each of the five days between last Friday and Tuesday.Deaths per day in the U.S. have repeatedly topped 3,000 over the past two weeks.Dr. Anthony Fauci, the government’s top infectious-disease expert, said he is particularly worried about travel between Christmas and New Year’s. Fauci, who turned 80 on Thursday, said he and his wife would be celebrating his birthday and the holidays with their children on Zoom. 752