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WASHINGTON, Aug. 2 (Xinhua) -- The weakness of aging is associated with leaky calcium channels inside muscle cells and a drug already in Phase II clinical trials for the treatment of heart failure might plug those leaks, according to a report published Tuesday in the online edition of Cell Metabolism.Earlier studies by the research team led by Andrew Marks of Columbia University showed the same leaks underlie the weakness and fatigue that come with heart failure and Duchenne muscular dystrophy."It's interesting, normal people essentially acquire a form of muscular dystrophy with age," Marks said. "The basis for muscle weakness is the same." Extreme exercise like that done by marathon runners also springs the same sort of leaks, he added, but in that case damaged muscles return to normal after a few days of rest. A microscopic view shows smooth muscle cells derived from human embryonic stem cells showing the nuclei (blue) and proteins of the cytoskeleton (green) in this handout photo released to Reuters by the California Institute for Regenerative Medicine, March 9, 2009The leaks occur in a calcium release channel called ryanodine receptor 1 (RyR1) that is required for muscles to contract. Under conditions of stress, those channels are chemically modified and lose a stabilizing subunit known as calstabin1.Calcium inside of muscle cells is usually kept contained. When it is allowed to leak out into the cell that calcium itself is toxic, turning on an enzyme that chews up muscle cells. Once the leak starts, it's a vicious cycle. The calcium leak raises levels of damaging reactive oxygen species, which oxidize RyR1 and worsen the leak.The researchers made their discovery by studying the skeletal muscles of young and old mice. They also showed that 6-month-old mice carrying a mutation that made their RyR1 channels leaky showed the same muscular defects and weakness characteristic of older mice.When older mice were treated with a drug known as S107, the calcium leak in their muscles slowed and the animals voluntarily showed about a 50 percent increase in the amount of time spent wheel running. Now in clinical trials for patients with heart failure, the drug is known to work by restoring the connection between costabilin and RyR1.Despite considerable effort to understand and reverse age- related muscle wasting, there are no established treatments available. The new work suggests there may be hope in approaching the problem from a different angle."Most research has focused on making more muscle mass," Marks said. "What's different here is that we are focused not on muscle mass but on muscle function. More muscle doesn't help if it is not functional."

XICHANG, Sichuan, July 12 (Xinhua) -- China blasted off a new data relay satellite "Tianlian I-02" on Monday at the Xichang Satellite Launch Center in southwest Sichuan Province .The satellite was launched on a Long March-3C carrier rocket at 11:41 p.m. (Beijing Time), said sources with the center.Developed by the China Academy of Space Technology under the China Aerospace Science and Technology Corporation, the satellite is the country's second data relay satellite.China launched its first data relay satellite "Tianlian I-01" on April 25, 2008.The two satellites will form a network to offer data relay and measurement and control service for China's spacecrafts and planned space stations, according to the center.They will also be used to help perform the nation's first space docking, scheduled for the second half of 2011.China plans to launch Tiangong-1 and Shenzhou-8 spacecraft in the latter half of this year, and they will perform the nation's first space docking.Monday's launch is the 140th mission of China's Long March series of rockets.

MOSCOW, Sept. 21 (Xinhua) -- A Russian Proton-M carrier rocket carrying a military spacecraft blasted off early Wednesday from the Baikonur space center in Kazakhstan, the first launch since a series setbacks of Russian rocket launch in August.Colonel Alexei Zolotukhin, spokesman of the Russian Space Forces, told reporters that the successful launch took place at 02:47 Moscow time (2247 GMT Tuesday) as scheduled."The spacecraft is scheduled to separate from the Briz-M booster at 11:48 Moscow time (0748 GMT)," Zolotukhin said.The military spacecraft delivered by the Proton-M belongs to the Russian Defense Ministry.Local reports said the Wednesday launch was originally planned for Aug. 31, but was postponed due to an investigation into a failed launch of a Proton-M rocket carrying an Express-AM4 satellite on Aug. 18.After the failure, Russia decided to suspend launches of rocket Proton-M pending the outcome of a probe into the accident.On Aug. 24, a Progress M-12M cargo ship also failed to reach the orbit due to a rocket malfunction. Russia delayed the launch of next manned spaceship to the International Space Station (ISS).

CANBERRA, Aug. 29 (Xinhua) -- Alzheimer Australia on Monday released a GPS device for people with dementia, in a move to give them greater independence, while reducing the burden of missing person searches for police.The technology has been using in New South Wales of Australia, and is now available for people in state Victoria.The Safe2Walk locater can be worn by people with dementia on a lanyard around the neck or clipped onto a belt. Families can log- on to the connected website and see where the person is.The device updates the person's location every 60 seconds, reducing stress for carers so they know when a person with dementia might be wandering.It also works as a mobile phone, letting the person wearing the device to make instant calls to family.According to Alzheimer's Australia's research manager Jason Burton, the device aimed to stop vulnerable people getting lost, with research showing about 40 percent of people with dementia went missing at least once."In 99 percent of cases the carer has gone to pick them up, but there was one case where they couldn't and the police were able to contact us to get the exact GPS location of this person to rescue them," Burton told Herald Sun.A Victoria Police spokeswoman said while it could not endorse a specific product, if the device could alert carers when a person with dementia first became disorientated, the response could help avoid a large-scale police search.Mina Sapounakis, who's father has worn the Safe2Walk device, said it has given her family a sense of calm."We could go grocery shopping without stressing and rushing back home quickly to check on Dad," she said."There were a few times he had gone wandering and we were able to easily find him without having to call the police."The Safe2Walk GPS costs under 15 U.S. dollars a week for rent.

TAIPEI, Sept. 11 (Xinhua) - As the full moon emerged in the remote sky, families and friends, bringing their barbecue grills, meat, seafood and vegetables, gathered under the Dazhi Bridge nearby Jilong River, one of major barbecue sites for the Mid-Autumn Festival in Taipei.Many families came to the barbecue site as early as at 3 p.m. Sunday for preparation. A Taipei citizen surnamed Wu in his sixties brought all his 30 family members to the barbecue."Every year, our family come out for barbecue only at the occasion of Mid-Autumn Festival, because the festival is for family reunion," he said.He also brought some fireworks to celebrate the traditional Chinese festival.Together with Wu's family, hundreds of people gathered under the bridge for barbecue, an unique scene in Taiwan for the Mid-Autumn festival.Mooncakes are a traditional delicacy for the Mid-Autumn Festival, which falls on the fifteenth day of the eighth month on the lunar calendar, or Sept. 12 this year. The round mooncakes resemble the full moon, a symbol of family reunion in traditional Chinese culture as well as the major theme of the Mid-Autumn Festival.According to some local residents, in the 1980s several barbecue sauce companies competing for the market frequently organized fairs to promote barbecue-related products just before the Mid-Autumn festivals.Through the intensive promotion campaigns, barbecue eventually became a Mid-Autumn festival custom as important as eating mooncake in Taiwan.But mooncake and pineapple cake are still popular gifts for the traditional festival in Taiwan. Weeks ahead of the festival, the advertisements for different brands of mooncake and pineapple cake were carried on local newspapers.Between Ren'ai Road and Xinyi Road in downtown Taipei, there is a weekend flower market becoming one of the options for Taipei citizens to while off the Mid-Autumn Festival holiday.The flower market with 29-year history is in fact a parking lot during weekdays. But during the weekend, the 1.5-hectare area becomes one of the biggest flower markets in Taipei, with about 300 booths selling flowers and plants.A flower seller, surnamed Yang, said the number of buyers increased significantly on Saturday and Sunday, the first two days of the three-day Mid-Autumn Festival holiday and the sales rose by nearly 30 percent.The flower market also held an agricultural product fair on Sept. 10-12, on which tea, fruits and other agricultural products are sold.