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WASHINGTON, March 25 (Xinhua) -- Researchers at the University of Colorado (CU) and the Harvard University have found that people living at higher altitudes have a lower chance of dying from ischemic heart disease and tend to live longer than others, according to a study published this week in the Journal of Epidemiology and Community Health.They spent four years analyzing death certificates from every county in the United States. They examined cause-of-death, socio- economic factors and other issues in their research.They found that of the top 20 counties with the highest life expectancy, eleven for men and five for women were located in Colorado and Utah. And each county was at a mean elevation of 5, 967 feet above sea level. The men lived between 75.8 and 78.2 years, while women ranged from 80.5 to 82.5 years.Compared to those living near sea-level, the men lived 1.2 to 3. 6 years longer and women 0.5 to 2.5 years more."If living in a lower oxygen environment such as in our Colorado mountains helps reduce the risk of dying from heart disease it could help us develop new clinical treatments for those conditions," said Benjamin Honigman, professor of Emergency Medicine at the CU School of Medicine. "Lower oxygen levels turn on certain genes and we think those genes may change the way heart muscles function. They may also produce new blood vessels that create new highways for blood flow into the heart."Another explanation, he said, could be that increased solar radiation at altitude helps the body better synthesize vitamin D which has also been shown to have beneficial effects on the heart and some kinds of cancer.Despite these numbers, the study showed that when socio- economic factors, solar radiation, smoking and pulmonary disease were taken into account, the net effect of altitude on overall life expectancy was negligible.Still, Honigman said, altitude seems to offer protection against heart disease deaths and may also play a role in cancer development.Colorado, the highest state in the nation, is also the leanest state, the fittest state, has the fewest deaths from heart disease and a lower incidence of colon and lung cancer compared to others.
WASHINGTON, April 6 (Xinhua) -- A study led by researchers at the University of Michigan (U-M) showed in animal studies that new cancer drug compounds they developed shrank tumors, with few side effects.The study, done in two mouse models of human cancer, looked at two compounds designed to activate a protein that kills cancer cells. The protein, p53, is inactivated in a significant number of human cancers. In some cases, it is because another protein, MDM2, binds to p53 and blocks its tumor suppresser function. This allows the tumor to grow unchecked. The new compounds block MDM2 from binding to p53, consequently activating p53."For the first time, we showed that activation of p53 by our highly potent and optimized MDM2 inhibitors can achieve complete tumor regression in a mouse model of human cancer," says lead study author Shaomeng Wang, director of the Cancer Drug Discovery Program at the U-M Comprehensive Cancer Center.Wang presented the study Wednesday at the American Association for Cancer Research 102nd annual meeting.Many traditional cancer drugs also activate p53 but they do so by causing DNA damage in both tumor cells and normal cells, causing side effects. These new MDM2 inhibitors activate p53 while avoiding the DNA damage common with other drugs. In this study, which was done in collaboration with Ascenta Therapeutics and Sanonfi-Aventis, researchers showed that these new drugs shrank tumors without significant side effects.Because p53 is involved in all types of human cancer, the new drug has potential to be used in multiple types of cancer. Further, the researchers also identified certain markers in tumors that predict which ones will be particularly sensitive to the MDM2 inhibitor, which would allow physicians to target the drug only to patients most likely to benefit.

BEIJING, Feb. 1 (Xinhua) -- Two Air China passenger planes carrying 457 Chinese citizens stranded in Egypt are due to arrive in Beijing early morning on Wednesday.The planes took off from the Cairo International Airport respectively at 11:16 and 15:32 local time (0916 and 1332 GMT) on Tuesday.The Civil Aviation Administration of China (CAAC), the nation's aviation authority, said Tuesday it was doing its best to organize flights to Egypt to bring home Chinese tourists stranded in the North African nation.China has arranged six flights to fly stranded Chinese nationals home, the CAAC said in a statement posted on its website.
HAIKOU, Jan. 28 (Xinhua) -- China's aviation authorities on Friday started to allow helicopters to fly in low-altitude airspace over the tourist island of Hainan on a trial basis for the first time. The aim is to eventually open a part of the country's tightly-controlled airspace to private aircraft.Four helicopters were manned by eight pilots from Shanghai-based Zhengyang Investment Group, a leading domestic firm in the general aviation industry. They are expected to conduct test flights in the sky, 1,000 meters above the ground in Hainan in the next two months.The flight test will collect data for low-altitude flying and test the ground control system's response to emergencies, said Zou Jianming, chairman of Zhengyang Investment Group.Hainan is the first place in China to conduct test flights of private aircraft in low-altitude airspace, said Jiang Sixian, deputy governor of the province. Domestic and foreign firms are both welcome to invest in Hainan's general aviation sector to develop world-class tourism here.China's low-altitude airspace is controlled by the Air Force and the Civil Aviation Administration of China (CAAC). Every private aircraft flight needs approval, and the procedure can take from one day up to a week.But last November, the State Council and the Central Military Commission said that part of the low-altitude airspace would be opened to promote the country's general aviation sector, including the purchase and use of private planes.General aviation refers to the part of the aviation industry that excludes flights for military, law enforcement and public transport. China has only 900 aircraft, 80 airports and fewer than 10,000 pilots in the general aviation segment.The market for general aviation in China is valued at only 13 billion yuan (1.98 billion U.S. dollars) but is expected to grow by 15 percent annually until 2020, Hainan aviation officials said.
WASHINGTON, April 29 (Xinhua) -- A U.S. appeals court ruled on Friday that the Obama administration can continue the taxpayer- funding for human embryonic stem cell research.The U.S. Court of Appeals in Washington overturned a preliminary federal court order that would have blocked the U.S. Health and Human Services Department and the National Institutes of Health (NIH) from spending government money on embryonic stem cells research."Today's ruling is a victory for our scientists and patients around the world who stand to benefit from the groundbreaking medical research they're pursuing," said Nicholas Papas, a White House spokesman.U.S. President Barack Obama has been trying to expand government funding for human embryonic stem cells research, saying that years of progress on finding cures for spinal cord injuries, Parkinson's disease and other diseases would be lost without the government support on this field.Opponents have been arguing the research is unacceptable because embryonic stem cells can only be obtained through destroying human embryos.Last August, a federal judge ruled that the government-backed embryonic stem cell research violated the law because embryos were destroyed in the process and it jeopardized the position of researchers using adult stem cells for winning federal grants.The government immediately appealed to the ruling, and the appeals court said the research could continue at the NIH before the judge ruled on the case.
来源:资阳报