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CBP officers later extracted approximately 3,014 pounds of methamphetamine, 64 pounds of heroin, 29 pounds of fentanyl powder, and almost 37 pounds of fentanyl pills, worth an estimated .2 million. 207

CARLSBAD, Calif. (KGTV) — LEGOLAND California Resort in North San Diego County is now hiring to fill 200 new job openings, preparing for the influx of visitors for spring break and summer seasons.The family-friendly theme park is encouraging you to apply, especially if it's your first job."Joining us NOW for spring break means you guarantee a summer of working with the Park, experiencing fantastic social events and be well placed for promotion opportunities to grow a career internally," LEGOLAND? reports. 523

Bulked-up, mutant “mighty mice” held onto their muscle during a monthlong stay at the International Space Station, returning to Earth with ripped bodybuilder physiques, scientists reported Monday.The findings hold promise for preventing muscle and bone loss in astronauts on prolonged space trips like Mars missions, as well as people on Earth who are confined to bed or need wheelchairs.A research team led by Dr. Se-Jin Lee of the Jackson Laboratory in Connecticut sent 40 young female black mice to the space station in December, launching aboard a SpaceX rocket.In a paper published in the Proceedings of the National Academy of Sciences, Lee said the 24 regular untreated mice lost considerable muscle and bone mass in weightlessness as expected — up to 18%.But the eight genetically engineered “mighty mice” launched with double the muscle maintained their bulk. Their muscles appeared to be comparable to similar “mighty mice” that stayed behind at NASA’s Kennedy Space Center.In addition, eight normal mice that received “mighty mouse” treatment in space returned to Earth with dramatically bigger muscles. The treatment involves blocking a pair of proteins that typically limit muscle mass.A SpaceX capsule brought all 40 mice back in good condition, parachuting into the Pacific off the California coast in January. Some of the ordinary mice were injected with the “mighty mice” drug after returning and quickly built up more muscle than their untreated companions, Lee said.The scientists completed the experiment just as the coronavirus was hitting the U.S.“The only silver lining of COVID is that we had time to write it up very intensively” and submit the results for publication, said Dr. Emily Germain-Lee of Connecticut Children’s Medical Center, Lee’s wife who also took part in the study. Both are affiliated with the University of Connecticut.While encouraged by their findings, the couple said much more work needs to be done before testing the drug on people to build up muscle and bone, without serious side effects.“We’re years away. But that’s how everything is when you go from mouse to human studies,” Germain-Lee said.Lee said the experiment pointed out other molecules and signaling pathways worth investigating — “an embarrassment of riches ... so many things we’d like to pursue.” His next step: possibly sending more “mighty mice” to the space station for an even longer stay.Three NASA astronauts looked after the space mice, performing body scans and injections: Christina Koch and Jessica Meir, who performed the first all-female spacewalk last fall, and Andrew Morgan. They are listed as co-authors.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2835

By JOYCE M. ROSENBERG and KEN SWEET AP Business WritersNEW YORK (AP) — Americans are likely to see more "for rent" signs in the coming months. That's because many businesses devastated by the coronavirus pandemic are expected to abandon offices and storefronts. The changes are happening because more employees are working from home, and more people are shopping online. The result could bring an end to the long boom in the nation's commercial real estate market. Hotels, restaurants and stores that closed in March have seen only a partial return of customers. Many of them may fail. Commercial landlords have reported an increase in missed rent payments. They expect vacancies to rise through the end of the year. 724

CARLSBAD, Calif. (KGTV) - The dollar value racked up by the Apple store bandits is now climbing toward the million-dollar mark.Surveillance images from an Apple store in Carlsbad in May show a group of men in hoodies walking in and immediately getting to work."They quickly grab the products on display near the front of the store," said Mark Herrring, coordinator of the San Diego County Crime Stoppers program.Investigators believe the same men hit the same store in June and several times in July."They flee the store, usually to a vehicle that is waiting for them," said Herring.The thieves have apparently shopped around for local targets.  Authorities released more images from a similar case at an Apple store at Westfield North County on July 9.  Detectives believe the local cases are linked to other grab-and-runs from across the state this year."Currently there are  approximately 30 cases throughout the state. The merchandise is valued at about 0,000."In some cases, people have gotten hurt. In a theft in Costa Mesa, the thieves punched and kicked an off-duty police officer trying to stop them before they ran off. Sources tell 10News the thieves hit three stores last Friday night, including one in Temecula.    "Most likely an arrest in this case is the only way this stops," said Herring.In one of the cases outside San Diego County, witnesses saw the men take off in a silver Infiniti sedan.  If you have any information, call Crime Stoppers at 888-580-8477. 1548