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INDIANAPOLIS — The U.S. Food and Drug Administration on Monday granted emergency use authorization to Eli Lilly and Company's experimental COVID-19 antibody treatment bamlanivimab.According to a statement from the company, the drug is authorized for the treatment of mild to moderate COVID-19 in adults and pediatric patients 12 years and older with a positive COVID-19 test who are at high risk for progressing to severe COVID-19 and/or hospitalization. Lilly said in a statement the drug should be administered as soon as possible after a positive COVID-19 test and within 10 days of symptom onset. The authorization allows for the distribution and emergency use of bamlanivimab, which is administered via a single intravenous infusion."This emergency authorization allows us to make bamlanivimab available as a COVID-19 treatment for recently diagnosed, high-risk patients — adding a valuable tool for doctors fighting the now-increasing burden of this global pandemic," David A. Ricks, Lilly's chairman and CEO, said. "The rapid development and availability of bamlanivimab could not have been achieved without the relentless work of our Lilly team, collaboration across the industry and the urgent work being done by the government to ensure appropriate allocation to patients who need it the most."The emergency use authorization is based on data from BLAZE-1, a randomized, double-blind, placebo-controlled Phase 2 study in patients with recently diagnosed mild to moderate COVID-19 in the outpatient setting. Patients treated with the drug showed reduced viral load and rates of symptoms and hospitalization, Lilly said in the statement. Infusion reactions and other allergic hypersensitivity events have been reported, Lilly said. The emergency use authorization includes a warning for hypersensitivity including anaphylaxis and infusion-related reactions.Lilly said the drug is not authorized for use in patients who are hospitalized due to COVID-19 or who require oxygen therapy due to COVID-19 or who require an increase in baseline oxygen flow rate due to COVID-19 in those on chronic oxygen therapy due to underlying non-COVID-19 related comorbidity."The BLAZE-1 data show bamlanivimab, when given early in the disease course, may help patients clear the virus and reduce COVID-related hospitalizations, supporting our belief that neutralizing antibodies can be an important therapeutic option for patients fighting this virus," Daniel Skovronsky, M.D., Ph.D., Lilly's chief scientific officer and president of Lilly Research Laboratories, said. "We're proud of the speed with which we have been able to bring patients this therapy specifically designed to treat COVID-19. We thank those who have contributed to this medical advancement, particularly the clinical trial investigators and participants around the country." This article was written by Bob Blake for WRTV. 2906
As the holiday season approaches, organizers for the Times Square New Year’s Eve celebration said this year’s festivities will be “virtually enhanced” and very different.This year, the celebration will bring Times Square and The Ball to the audience digitally, no matter where they are.A scaled back and socially distanced live production is still being determined."People all over the globe are ready to join New Yorkers in welcoming in the new year with the iconic Ball Drop. I commend the Times Square Alliance, Jamestown Properties, and Countdown Entertainment on finding a safe, creative and innovative way for all of us to continue to celebrate this century old-tradition. A new year means a fresh start, and we’re excited to celebrate,” said Mayor Bill de Blasio.“One thing that will never change is the ticking of time and the arrival of a New Year at midnight on December 31st,” said Tim Tompkins, President of the Times Square Alliance, which co-produces the event with Countdown Entertainment.“Because any opportunity to be live in Times Square will be pre-determined and extremely limited due to COVID-19 restrictions, there will be the opportunity to participate virtually wherever you are. Because more than ever in these divided and fear-filled times, the world desperately needs to come together symbolically and virtually to celebrate the people and things we love and to look forward with a sense of renewal and new beginnings,” Tompkins added.Due to the ongoing coronavirus pandemic, many events have been canceled or modified to fight the spread of the virus. The New Year’s Eve Times Square ball drop, which typically brings millions of people together in Manhattan, is no different.Earlier this month, the mayor and Macy's announced the annual Thanksgiving Day Parade will be "reinvented" with virtual aspects. The Macy's Fourth of July fireworks were also modified into smaller fireworks displayed before a grand show was aired on television. This story originally reported y Kristine Garcia on PIX11.com. 2053

For more than 40 years, The Guardian Angels have been putting their lives on the line to protect citizens. The group, which is made up of volunteers, don't get paid and don't carry weapons. Advocates of the group say they have made a big difference in public safety. But the group is having trouble attracting new members, and it's losing its headquarters in Colorado. It’s Saturday evening on one of Denver’s most dangerous streets, when the calls of concerns start coming in. “We got a report from a passerby about an individual shooting over here,” said Robi Salo, commander of the Colorado Guardian Angels. The word "shooting" refers to drug use, and that's exactly what Salo and his team found when they arrived to the scene. They approached young man, sitting in a parking lot with a needle in his hand. “We aren’t going to bust your b***s or nothing,” Salo says. “If you’re going to shoot, you’re going to shoot.”The young man decides, at least while the Guardian Angels are around, not to inject himself with drugs. Salo chalks it up a small win. Back in the day, the Guardian Angels had a reputation of being a Robin Hood, while robbing drug dealers and donating that money to local shelters. The group started out protecting New York City subway riders in the late 1970’s. The Colorado Guardian Angel chapter opened in Denver in 1993. Twenty-six years later, their numbers are dropping, their members are getting older and they’re losing their headquarters.“The numbers have dwindled over the years,” Salo says of the Colorado Guardian Angels. “Instead of having 100 active, we have 25 maybe on the deep list; probably about 12 that are heavily active. And we’re aging. I’m 55 we have members that are as old as 70.”Salo says while there are more Guardian Angels chapters across the country, the number of active members has stayed the same at around 3,000 since the mid-1990’s. The angels are aging out, but there is hope to replace them. “I’m kind of, right now, a rookie; fresh meat,” said Zane Salazar, who at 16 years old is following his father’s footsteps in becoming a Guardian Angel. “We want to show the community that we’re out there, show the community that we care, and I think people will come along if they see that.”We reached out to several national and local law enforcement agencies for their take on the Guardian Angels. None of them wanted comment, but police departments typically don't encourage citizens to take the law into their own hands. Their opinions on the Guardian Angels have been mixed over the years. 2558
Kyle Rittenhouse's attorney has filed a motion to dismiss two charges late Tuesday.According to court records, they seek to dismiss Possession of a Dangerous Weapon by a Person Under 18, and First Degree Recklessly Endangering Safety, Use of a Dangerous Weapon.Rittenhouse is facing a total of six charges, including two counts of 1st-Degree Reckless Homicide after prosecutors say he shot and killed two people and wounded a third during protests in Kenosha.Attorney Mark Richards argues in Tuesday's filing that possession of a dangerous weapon by a person under 18 should be dismissed because "the complaint [filed against Rittenhouse] fails to allege facts which could allow a reasonable person to conclude that a crime was committed."In regard to first-degree recklessly endangering safety, Richards writes that "no reasonable person could find that this crime was ever committed. Thus, the criminal complaint is defective and Count 2 should be dismissed." FILE - In this Tuesday, Aug. 25, 2020, file photo, Kyle Rittenhouse carries a weapon as he walks along Sheridan Road in Kenosha, Wis., during a night of unrest following the weekend police shooting of Jacob Blake. Rittenhouse's defense team has called him a member of a militia. Rittenhouse is accused of killing two people and seriously wounding a third.(Adam Rogan/The Journal Times via AP, File) The motion comes a day before Rittenhouse is set to attend his pretrial hearing in Kenosha County Court, on Dec. 3 at 10:30 a.m.Prosecutors allege Rittenhouse shot and killed Anthony M. Huber and Joseph Rosenbaum, and wounded Gaige Grosskreutz during protests in Kenosha on Aug. 25.Supporters of the Black Lives Matter movement paint Rittenhouse as a white supremacist and militia member. Rittenhouse and his attorneys argue that he acted in self-defense, an argument that has become a rallying cry for some on the right.If convicted, Rittenhouse could spend life behind bars.This article was written by Jackson Danbeck for WTMJ. 2040
My dad has only ever liked one video game - Galaga. He and my mom used to go play it on date nights when they were newly-weds and broke. This year, me and my siblings all pitched in to get him a Galaga arcade machine for Christmas. I don't think I've ever seen him more excited to get a present! 311
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