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The first experimental COVID-19 vaccine in the U.S. is on track to begin a huge study next month to prove if it really can fend off the coronavirus, while hard-hit Brazil is testing a different shot from China.Where to do crucial, late-stage testing and how many volunteers are needed to roll up their sleeves are big worries for health officials as the virus spread starts tapering off in parts of the world.Moderna Inc. said Thursday the vaccine it is developing with the National Institutes of Health will be tested in 30,000 people in the U.S. Some will get the real shot and some a dummy shot, as scientists carefully compare which group winds up with the most infections.With far fewer COVID-19 cases in China, Sinovac Biotech turned to Brazil, the epicenter of Latin America’s outbreak, for at least part of its final testing. The government of S?o Paulo announced Thursday that Sinovac will ship enough of its experimental vaccine to test in 9,000 Brazilians starting next month.If it works, “with this vaccine we will be able to immunize millions of Brazilians,” said S?o Paulo′s Gov. Joao Doria.Worldwide, about a dozen COVID-19 potential vaccines are in early stages of testing. The NIH expects to help several additional shots move into those final, large-scale studies this summer, including one made by Oxford University that’s also being tested in a few thousand volunteers in Brazil.There’s no guarantee any of the experimental shots will pan out.But if all goes well, “there will be potential to get answers” on which vaccines work by the end of the year, Dr. John Mascola, who directs NIH’s vaccine research center, told a meeting of the National Academy of Medicine on Wednesday.Vaccines train the body to recognize a virus and fight back, and specialists say it’s vital to test shots made in different ways — to increase the odds that at least one kind will work.Sinovac’s vaccine is made by growing the coronavirus in a lab and then killing it. So-called “whole inactivated” vaccines are tried-and-true, used for decades to make shots against polio, flu and other diseases — giving the body a sneak peek at the germ itself — but growing the virus is difficult and requires lab precautions.The vaccine made by the NIH and Moderna contains no actual virus. Those shots contain the genetic code for the aptly named “spike” protein that coats the surface of the coronavirus. The body’s cells use that code to make some harmless spike protein that the immune system reacts to, ready if it later encounters the real thing. The so-called mRNA vaccine is easier to make, but it’s a new and unproven technology.Neither company has yet published results of how their shots fared in smaller, earlier-stage studies, designed to check for serious side effects and how well people’s immune systems respond to different doses.Even before proof that any potential vaccine will work, companies and governments are beginning to stockpile millions of doses so they can be ready to start vaccinating as soon as answers arrive.In the U.S., a program called “Operation Warp Speed” aims to have 300 million doses on hand by January. Under Brazil’s agreement with Sinovac, the Instituto Butantan will learn to produce the Chinese shot.___AP journalist Marcelo Silva de Sousa contributed to this report.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3499
The Christian evangelist who attempted to convert one of the world's last remaining isolated tribes wrote of his convictions in pursuing the mission even in the face of open hostility and attempts on his life, according to diary entries and notes.In excerpts from his journal, John Allen Chau, the American who is believed to have been killed by members of the isolationist Sentinelese tribe on a tiny, remote island in the Bay of Bengal, wrote of returning to the island to continue his attempts at conversion even after a tribesman shot at him with a bow and arrow, piercing a Bible he was carrying."I hollered, 'My name is John, I love you and Jesus loves you,'" he wrote in his diary, pages of which were shared by his mother with the Washington Post. Shortly after, a young member of the tribe shot at him, according to his account.In pages left with the fishermen who facilitated his trip to the island, his musings are a clear indication of his desire to convert the tribe."Lord, is this island Satan's last stronghold where none have heard or even had the chance to hear your name?" he wrote.His notes indicate that he knew the trip was illegal, describing how the small fishing vessel transported him to the isolated island under cover of darkness, evading patrols."God Himself was hiding us from the Coast Guard and many patrols," he wrote.All seven locals who facilitated the trip have been arrested. 1419
The government is looking into getting rid of Transportation Security Administration (TSA) security at dozens of smaller airports across the country.According to reports, the TSA is considering getting rid of security screenings at more than 150 small and medium-sized airports that operate commercial flights, with no more than 60 passengers.The TSA estimates the move would save 5 million, which could then be used to enhance security at busier, larger airports. 475
The coronavirus has had a significant impact on sports, and now football is beginning to see the virus affect the sport.NFL Network reports that the league and players’ union agreed to not hold a preseason this fall, which would have gotten underway next month. Given football’s schedule, the games provide teams with revenue as they’re generally included in season ticket packages. The decision comes with the likelihood of teams playing in front of no or a limited number of fans during the regular season. Several states have said that large gatherings will be limited into the fall.NFL Network added the league will expand training camp rosters, and there will be an opt-out for players at a “high risk” of having coronavirus complications. 752
The city of Albuquerque, New Mexico, is answering calls to "defund the police" by creating a new public safety department that will send unarmed social workers instead of police officers in response to some 911 calls.On Monday, Albuquerque Mayor Tim Keller (D) said his administration would form a new city department, Albuquerque Community Safety, whose personnel would respond to some emergency calls.Albuquerque Community Safety officials will respond to calls of inebriation, homelessness, addiction and mental health. According to Keller's office, the department will be made up of social workers, housing and homelessness specialists, violence prevention and diversion program experts.Officials hope the new department will keep such calls from escalating into violence and will allow police officers to re-focus their efforts to combating and investigating violent crime."We want to send the right resource to the right call," Keller said in a statement. "Especially where a social worker or trained professional can connect people with the services they need, instead of simply taking folks to jail or the hospital, which have been the only choices until now."According to The Washington Post, experts believe that the Albuquerque Community Safety department may be the first of its kind. Though calls to defund police departments have strengthened following the death of George Floyd in May, Keller says the city has been working for two years on to change the way Albuquerque handles some emergency calls.Activists who are calling for cities to defund police departments say that money would be better spent on community outreach. They also say that sending armed police into some emergency situations can escalate situations and lead to violence, especially against racial minorities and people of color.In recent weeks, thousands of protesters have taken to the streets in dozens of major cities, calling for an end to police brutality and systemic racism following the death of George Floyd in Minneapolis.Floyd died in police custody after allegedly using a counterfeit bill to buy tobacco while intoxicated. After handcuffing Floyd, bystander video shows a police officer, later identified as Derek Chauvin, kneeling on Floyd's neck for more than eight minutes. Chauvin has been charged with second-degree murder, and three other officers face charges in connection with Floyd's death. 2412