南昌穿戴式环甲膜穿刺模型(陕西牙护理保健模型（带脸颊)(自然大）) (今日更新中)

WASHINGTON, Aug. 2 (Xinhua) -- The weakness of aging is associated with leaky calcium channels inside muscle cells and a drug already in Phase II clinical trials for the treatment of heart failure might plug those leaks, according to a report published Tuesday in the online edition of Cell Metabolism.Earlier studies by the research team led by Andrew Marks of Columbia University showed the same leaks underlie the weakness and fatigue that come with heart failure and Duchenne muscular dystrophy."It's interesting, normal people essentially acquire a form of muscular dystrophy with age," Marks said. "The basis for muscle weakness is the same." Extreme exercise like that done by marathon runners also springs the same sort of leaks, he added, but in that case damaged muscles return to normal after a few days of rest. A microscopic view shows smooth muscle cells derived from human embryonic stem cells showing the nuclei (blue) and proteins of the cytoskeleton (green) in this handout photo released to Reuters by the California Institute for Regenerative Medicine, March 9, 2009The leaks occur in a calcium release channel called ryanodine receptor 1 (RyR1) that is required for muscles to contract. Under conditions of stress, those channels are chemically modified and lose a stabilizing subunit known as calstabin1.Calcium inside of muscle cells is usually kept contained. When it is allowed to leak out into the cell that calcium itself is toxic, turning on an enzyme that chews up muscle cells. Once the leak starts, it's a vicious cycle. The calcium leak raises levels of damaging reactive oxygen species, which oxidize RyR1 and worsen the leak.The researchers made their discovery by studying the skeletal muscles of young and old mice. They also showed that 6-month-old mice carrying a mutation that made their RyR1 channels leaky showed the same muscular defects and weakness characteristic of older mice.When older mice were treated with a drug known as S107, the calcium leak in their muscles slowed and the animals voluntarily showed about a 50 percent increase in the amount of time spent wheel running. Now in clinical trials for patients with heart failure, the drug is known to work by restoring the connection between costabilin and RyR1.Despite considerable effort to understand and reverse age- related muscle wasting, there are no established treatments available. The new work suggests there may be hope in approaching the problem from a different angle."Most research has focused on making more muscle mass," Marks said. "What's different here is that we are focused not on muscle mass but on muscle function. More muscle doesn't help if it is not functional."

CAIRO, July 6 (Xinhua) -- Egypt's Central Administration of Agricultural Quarantine has denied again that the country's fenugreek seeds exported to Europe caused the E.coli infections which have claimed dozens of lives.The Egyptian authorities took and analyzed fenugreek seeds samples from the warehouse of the said Egyptian exporter and all results were negative by the strain, a statement posted on the official website of Egypt's Agricultural Ministry said on Wednesday."E.coli strain has not been reported in Egypt and no illness cases have been found," it added.If fenugreek seeds sprouts are suspected to be contaminated with E.coli pathogenic strain, it could be related to different handling processes, such as the re-packing or water used for sprouting, the statement said.The European Union (EU) on Tuesday agreed to ban the import of certain types of seeds from Egypt as Egyptian fenugreek seeds were reported to be linked with the outbreak of E.coli in Europe.The European Food Safety Authority (EFSA) published early Tuesday a report from its task force on the E.coli outbreaks in Germany and France, indicating that fenugreek seeds imported from Egypt is the most likely source of the outbreaks.The E.coli outbreak has killed over 50 people in Europe since it was first reported in late May.Russia's food safety watchdog Rospotrebnadzor has also banned the import of certain types of produce from Egypt over food safety concerns, a Russian official said on Wednesday.Egypt's Ministry of Agriculture refuted the claims of Egypt being the source of E.coli Friday.

BEIJING, Aug. 24 (Xinhua) -- China will prioritize the development of six types of new materials in its new material industry over the next five years, the China Securities Journal said on Wednesday.The report cited an insider, who noted that the country's 12th Five-Year Plan (2011-2015) for the new material industry will come out in September, in which the government will launch key projects to support the development of the six materials.The six materials will be high-strength light alloy, advanced iron and steel, carbon fiber composite, new power battery material, function coated material, and rare earth function material, according to the report.The plan states each of the six sub industries will form a sizable industrial scale, with the industry's total output value to hit trillions of yuan by the end of 2015, and the self-supply rate to reach 70 percent during the period, the report said.Meanwhile, the government will also foster the development of materials in sectors such as green building material and the biomedical industry over the next five years, it added.

MOSCOW, June 15 (Xinhua) -- Russia's Mission Control announced on Wednesday it had raised the International Space Station (ISS) by 10.2 km to 374.7 km with the help of the Europe's ATV-2 Johannes Kepler.The Mission Control conducted the correction to the ISS at 19: 55 Moscow time (1555 GMT) by the boosters of the ATV-2 Johannes Kepler. The correction had lasted for some 40 minutes.According to the Mission Control, the correction was made in line with the ISS's ballistic flight program.On June 12, the Europe's second Automated Transfer Vehicle (ATV) Johannes Kepler has conducted two similar operations, raising the ISS orbit by 19.2 km to 364.6 km.Corrections to the space station's orbit are conducted periodically before launches of Russian cargo ships and U.S. shuttles to compensate for the Earth's gravity and to safeguard successful dockings.According to the Mission Control, the ATV-2 Johannes Kepler is scheduled to undock from the ISS on June 21.

BEIJING, Sept. 6 (Xinhuanet) -- San Francisco police said they had helped Apple search for a "lost item," following reports saying that a prototype of Apple's yet-to-be-released iPhone 5 had gone missing in July.Last week, technology news website CNET reported that an Apple employee lost at a tequila bar in San Francisco in July a prototype of iPhone 5, a new version of the company's mobile phone expected to be released in September or October.The San Francisco Police Department said in a press release that after the missing device was tracked using GPS technology to a San Francisco house, four police officers and two Apple employees visited the home."Apple employees called Mission police station directly, wanting assistance in tracking down a lost item," the statement said."The two Apple employees met with the resident and then went into the house to look for the lost item," it said. "The Apple employees did not find the lost item and left the house."Police did not say exactly what Apple had lost, but media reports found the file of San Francisco police's Friday press release about the hunt was named "iphone5.doc" -- an apparent hint of the new mobile device.A 22-year-old resident of the home, identified by SF Weekly as Sergio Calderon, told the newspaper that he has visited the bar where the phone was reportedly lost but he did not have the device.Calderon said the search of his house took place in July when police had traced the phone to the house using satellite positioning software on the device, but did not find anything in the house.Apple has declined to comment on the matter.Last year, an employee of the company lost a prototype iPhone 4 in a Redwood City bar before it was released. The details of the phone ware then unveiled by technology blog Gizmodo.Criminal charges have been filed against the man who found the prototype and another who brokered the deal to sell it to Gizmodo. Both men pleaded not guilty on Thursday.

来源：资阳报