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SAN DIEGO (KGTV) -- County health officials are notifying people who may have been exposed to tuberculosis at locations throughout San Diego County. According to County News Center, three unrelated cases of the disease were reported in San Diego County between August 20 and October 18. Two of the cases were reported at San Diego County Sheriff’s detention facilities. RELATED: Tuberculosis case confirmed at San Diego Airport, exposure risk extremely lowThe third case was found in a person who arrived from out of town after being diagnosed with TB and spent time at one of the city’s bridge shelters. Investigators believe the individual arrived in San Diego after leaving a Long Beach hospital without permission. The third person died from “co-occurring medical conditions” at a local hospital on October 6. The periods of exposure are listed below: Aug. 20 to Sept. 6, 2019 at the San Diego Central Jail Detention FacilitySept. 6 to Sept. 15, 2019 at the George Bailey Detention FacilityOct. 16 to Oct. 18, 2019 at the Las Colinas Detention and Reentry FacilityAug. 20, 2019 to Sept. 9, 2019 at the 16th St. and Newton Ave. bridge shelterThe sheriff’s department is offering free testing for its staff and all identified people in custody while the County Health and Human Services Agency is offering free tests to those who may have been exposed and have no medical provider. RELATED: Tuberculosis case reported at Southwestern CollegeThe agency is also working with the City of San Diego, the San Diego Housing Commission and the Alpha Project to notify people who may have been exposed. Tuberculosis is transmitted from person to person through indoor air during prolonged contact with the infected person. According to health officials, most people who are exposed don’t become infected. 1807

SAN DIEGO (KGTV) - At least two people suffered major burns in a boat fire off the coast of San Diego late Saturday night, according to Coast Guard officials.Two patients were critically injured and were flown from the boat by helicopter and have been transported to the hospital. The total number of patients at this time is unknown. The rest are expected to be brought to the shore by boat. The circumstances of the fire and the type of boat are unclear at this time.This is a breaking news story. 10News will update as details become available. 575

SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) — Caltrans is starting a yearlong pilot program in San Diego to reduce wrong-way driving.The agency has installed markings at 30 locations that include red arrows and "DO NOT ENTER" written across the pavement that are only legible when driving in the wrong direction onto freeway ramps.The markings will stay up until the end of the year, according to Caltrans.The agency says that a previous three-year pilot program helped reduce wrong-way driving by 44% in San Diego. The program utilized special reflectors, sensors, and illuminated signs in early 2018.Now, those specialized reflectors have been installed on hundreds of miles of highways, according to Caltrans."The number of wrong-way drivers decreased significantly during the initial pilot program," said Caltrans Director Toks Omishakin. "The addition of these markings, along with what we have learned thus far, will go a long way as we continue to study ways to deter wrong-way drivers."While wrong-way crashes only account for less than 1% of all crashes on California's highways, they are often among the deadliest, Caltrans said."We are constantly looking for ways to improve safety on the transportation system," said Caltrans (San Diego area) District 11 Director Gustavo Dallarda. "If the testing of this new product is successful, it could provide a new tool to reduce wrong-way driving." 1383

SAN DIEGO (KGTV) - Attention is now turning to the southern border after Wednesday's border closure with Canada.On Thursday, the walkway into Tijuana was nearly empty but the San Ysidro Port of Entry remains open, for the time being. “It's going to have major implications for us, particularly for us here in Southern California, if we see a closing of the U.S.-Mexico border,” says Dr. David Shirk with the University of San Diego, where he works as a professor with an area of expertise in U.S.-Mexico relations. RELATED: Senate GOP to unveil stimulus plan that includes ,200 payments for most AmericansShirk says that if the U.S. proceeds with any closure, not only will families be separated, but there will also be a major shortage of supplies like foods that are harvested in Baja and transported north. “Something that the federal government needs to take into consideration is that our economy is critically interlinked with Mexico,” he adds.As of Thursday morning, there were only 118 reported cases of COVID-19 in Mexico. Mexican President Andrés Manuel López Obrador has been criticized in recent days for not taking enough containment measures. Video on the Washington Post's website shows him shaking hands at a big rally last Saturday and kissing a supporter. RELATED: San Diego County Westfield malls close 'majority of its operations' amid outbreakThursday, he tweeted out from a press conference to act calmly, disseminate official information and adopt hygiene measures. San Diego Mayor Kevin Faulconer said Thursday that he has requested for the State of Baja to adopt the same precautionary measures that are being taken in San Diego.This Wednesday, the Mayor of Tijuana decided to cancel events with more than 100 people. Schools in Tijuana are reportedly now closed. RELATED: San Diego and national closures, cancellations, postponements due to COVID-19Shirk says Mexico has likely been slower to respond to the pandemic out of fears over its own economy. “I think there's real concern in the López Obrador Administration that an overly drastic response to the coronavirus crisis could cripple Mexico's economy and that has to do with the fact that for the last couple of years Mexico's growth rate has basically remained about flat," Shirk. U.S. Customs and Border Protection (CBP) sent 10News a statement about any possible plans for a border closure:“What we can say right now is that the U.S. Customs and Border Protection’s (CBP) highest priority is to ensure the health, safety and security of our workforce and the American people. CBP agents and officers will maintain situational awareness while identifying individuals who have traveled from or transited through countries affected by COVID-19. CBP continues to process cargo as there has been no identified threat as it relates to cargo shipments.CBP officers use a combination of traveler history records, questioning, observation, and self-declarations to further identify individuals requiring enhanced health screening by the Centers for Disease Control and Prevention (CDC). Currently, all CBP ports of entry are following the same operational guidance as issued by Presidential Proclamations and the Department of Homeland Security. If CBP observes a traveler with symptoms of COVID-19, we will refer them to the (CDC) and or DHS medical contractors for enhanced health screening. CDC personnel are responsible for the enhanced health screening of travelers in all locations nationwide.CBP has issued guidance to all employees that outlines the current comprehensive use of Personal Protective Equipment including guidance regarding wearing masks in the appropriate circumstances. (using a risk-based approach).” 3711

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