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WASHINGTON, April 25 (Xinhua) -- Study by scientists at the Rockefeller University shows that anti-inflammatory drugs reduce the effectiveness of the most widely used class of antidepressant medications, the selective serotonin reuptake inhibitors (SSRIs), taken for depression and obsessive-compulsive disorder and anxiety disorders.This discovery, published online Monday in the Proceedings of the National Academy of Sciences, may explain why so many depressed patients taking SSRIs do not respond to antidepressant treatment and suggests that this lack of effectiveness may be preventable.The study may be especially significant in the case of Alzheimer's disease. Such patients commonly suffer from depression and unless this can be treated successfully, the course of the illness is likely to be more severe. Depression in the elderly is also a risk factor for developing Alzheimer's Disease and researchers have suggested that treating depression in the elderly might reduce the risk of developing the disease.In the recent study, investigators treated mice with antidepressants in the presence or absence of anti-inflammatory drugs. They then examined how the mice behaved in tasks that are sensitive to antidepressant treatment. They found that the mice's behavioral responses to antidepressants were inhibited by anti- inflammatory/analgesic treatments.They then confirmed these effects in a human population. Depressed individuals who reported anti-inflammatory drug use were much less likely to have their symptoms relieved by an antidepressant than depressed patients who reported no anti- inflammatory drug use. The effect was rather dramatic since, in the absence of any anti-inflammatory or analgesic use, 54 percent of patients responded to the antidepressant, whereas success rates dropped to approximately 40 percent for those who reported using anti-inflammatory agents."Many elderly individuals suffering from depression also have arthritic or related diseases and as a consequence are taking both antidepressant and anti-inflammatory medications. Our results suggest that physicians should carefully balance the advantages and disadvantages of continuing anti-inflammatory therapy in patients being treated with antidepressant medications," leader author Paul Greengard said.

WASHINGTON, March 22 (Xinhua) -- A long-term study by Greek researchers has shown the effectiveness of replacing bone marrow, purposely destroyed by chemotherapy, with autologous (self) stem cells in treating people with aggressive forms of multiple sclerosis (MS).The study was published on Tuesday in Neurology, the medical journal of the American Academy of Neurology.For the treatment, chemotherapy drugs are used to kill all of the patient's blood cells, including the immune cells that are believed to be attacking the body's own central nervous system. Bone marrow stem cells removed from the patient are purified and transplanted back into the body, which saves life by replacing the blood cells and also is proposed to "reboot" the immune system.A human embryonic stem cell line derived at Stanford University is seen in this handout photo released to Reuters by the California Institute for Regenerative Medicine, March 9, 2009The study followed 35 people for an average of 11 years after transplant. The study involved people with rapidly progressive MS who had tried a number of other treatments for MS with little or no effect. All were severely disabled by the disease, with an average score of six on a scale of disease activity that ranges from zero being a normal neurological examination to 10 meaning death due to MS.A score of six means able to walk with a cane or crutch; a seven is mainly in a wheelchair. All had worsened by at least one point on the scale in the year prior to the transplant.After the transplants, the probability of participants having no worsening of their disease for 15 years was 25 percent. The probability was higher -- 44 percent -- for those who had active brain lesions, which are a sign of disease activity, at the time of the transplant.For 16 people, symptoms improved by an average of one point on the scale after the transplant, and the improvements lasted for an average of two years. The participants also had a reduction in the number and size of lesions in their brains. Two people (six percent) died from complications related to the transplant at two months and 2-1/2 years post-transplant.Study author Vasilios Kimiskidis, of Aristotle University in Thessaloniki, Greece, noted that more research is needed on this treatment, including studies that compare people receiving the treatment to a control group that does not receive the treatment."Keeping that in mind, our feeling is that stem cell transplants may benefit people with rapidly progressive MS," he said. "This is not a therapy for the general population of people with MS but should be reserved for aggressive cases that are still in the inflammatory phase of the disease."

BEIJING, March 29 (Xinhuanet) -- Tickets for Apple's annual World Wide Developer Conference (WWDC) 2011 have already been sold out ten hours after the event was announced Monday, according to media reports.It is the first time the event sold out the same day it was announced. Last year, the conference sold out in eight days.WWDC 2011, with the tickets priced at 1599 U.S. dollars, will run from June 6 till June 10 at the Moscone West conference center in San Francisco.This year's speedy turnaround is probably because of a rumored double-focus on iOS and Mac OS."At this year's conference we are going to unveil the future of iOS and Mac OS," Philip Schiller, Apple's senior vice president of Worldwide Product Marketing, said in a press release."If you are an iOS or Mac OS X software developer, this is the event that you do not want to miss."The event will feature more than 100 technical sessions presented by Apple engineers on Application Frameworks; Graphics, Media and Games; Developer Tools; Internet and Web, and Core OS.

SANAA, Feb. 6 (Xinhua) -- In response to earlier reports that a Chinese-flagged commercial ship was hijacked by Somali pirates off Yemeni coast, the China Maritime Search and Rescue Center (MSA) said Sunday that the ship has never been hijacked, and is now sailing safely with escort of the Chinese anti-piracy navy fleet.Both the "Tien Hau" ship, which was registered in Hong Kong, China, and its 22-member crew, are safe, a MSA official confirmed to Xinhua over the phone. The center contacted the ship to make sure it was safe, he added.The ship had been followed by a suspicious boat for a while, but it was never attacked or hijacked, the official said.Earlier, Yemeni Interior Ministry had said the ship was hijacked by pirates some 20 kilometers off the Yemeni island of Al-Tair off the city port of al-Hudaida, and was heading to Somali coast.The Gulf of Aden is considered as one of the world's most dangerous waters because of rampant piracy.

CANBERRA, April 14 (Xinhua) -- Scientists on Thursday expressed disappointment to the decision to cancel the long-running Australian Science Festival in Canberra.The festival has been operating during August for the past 19 years with free and ticketed science education activities.However, the festival organizers on Wednesday announced to halt this year's program after failing to secure support from the Australian Capital Territory state government in time to arrange events.According to Australian Science Communicators president, Jesse Shore, thousands of school children have attended the festival over its history to learn more about science as a career."It's encouraged other activities to join it, it was very important in getting National Science Week started, and that's stimulated a lot of other science communication activities," he told ABC News on Thursday.Shore said the decision to close it down is unfortunate as the event has been very influential and instrumental promoting science communications activities.He said he hopes that a number of people would gather together in a new partnership, with new ideas and hopefully a new funding base.