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SAN DIEGO (KGTV) -- The FBI is investigating following a hazmat situation in La Jolla Thursday afternoon. According to authorities, the incident started around 1 p.m. on the 9400 block of La Jolla Farms Road near UCSD and the Scripps Reserve trail. Throughout the afternoon, people who appeared to be workers at the home could be seen sitting outside with bags wrapped around their lower legs. The unidentified substance is being cleaned up by hazmat crews and, at this time, it's unclear what led to the situation. Neighbors say the home was being rented out and a new tenant recently moved in.The Department of Environmental Health said they found a contaminant and that it is contained with no threat to the community.The final Hazmat crews left around 7:30 p.m. 798

SAN DIEGO (KGTV) — The Department of Defense has awarded a San Diego biotech company up to million to help develop a next-generation drug to fight COVID-19.Sorrento Therapeutics calls the drug a “rapid countermeasure” against the disease, one that might serve as a vaccine substitute in certain populations or a critical stopgap tool if the virus mutates.“With this, we have a new platform potentially that can respond very quickly to any type of emerging threat,” said CEO Dr. Henry Ji.Sorrento is trying to become the first company to develop an approved DNA-encoded monoclonal antibody treatment. The approach is similar to the experimental monoclonal antibody treatment used on President Trump, but Sorrento’s concept is a more advanced version that offers several benefits.Sorrento’s drug is designed to be used as either a treatment in infected patients or a fast-forming layer of defense in healthy people. The company said its solution should be cheaper and easier to deploy than existing monoclonal antibodies, while offering vaccine-like protective effects that last for several months rather than just two or three weeks.Antibodies are one of the body’s key defense mechanisms. They seek out pathogens and bind to them, marking the invader for destruction like ground troops marking an enemy base for an airstrike. In some cases, antibodies can even neutralize an invader themselves by blocking its method of entry into cells.Monoclonal antibodies are antibodies designed by scientists to neutralize a pathogen. They are hand-picked, genetically modified super antibodies that are cloned in labs.However, the process of growing these super soldiers in the lab is difficult, transporting them requires a cold chain, and as a result, monoclonal antibodies are among the most expensive drugs in the world.Instead of giving people an infusion of pre-made antibodies, Sorrento’s idea is to give people a shot of DNA that instructs some of their cells to churn out perfectly pre-designed antibodies.“It's much easier to make enough DNA to treat a large number of people than it is to make enough protein to treat a large number of people. That’s just a fact about manufacturing,” said Dr. Robert Allen, Sorrento’s chief scientific officer on the project.Dr. Allen said the company is hopeful the drug will induce cells to make protective antibodies for six months or more.This DNA approach to an antibody treatment has never been approved for any disease but other companies are working on their own versions of it. Another biotech with ties to San Diego, Inovio Pharmaceuticals, became the first company to test this approach in humans in 2019 for a drug targeting the Zika virus.Sorrento’s approach is similar to the way DNA vaccines work, but it cuts out intermediary steps and jumpstarts the production of antibodies, rather than leaving the production of antibodies up to the body’s immune system. The result is that protective antibodies can start circulating in days after injection rather than weeks, the company said.“What this is capable of doing is it bypasses the need for the immune system,” said Dr. Mark Brunswick, Sorrento’s senior vice president for regulatory affairs.The drug is unlikely to replace a vaccine in most situations because vaccines can produce other defense mechanisms like T-cells that work in conjunction with antibodies. But the drug might work better than a vaccine for the elderly and others with weakened immune systems who are unable to produce a robust number of antibodies on their own, Brunswick said.Still, the company still has a lot of pre-clinical work and testing to go. Sorrento is hoping to have the drug ready for human trials in four to six months.By then, vaccines from Pfizer and Moderna will likely be widely available, but Dr. Ji said the world needs to prepare for the possibility this virus will mutate.“When you vaccinate hundreds of millions, potentially billions of people, the virus is under tremendous evolution pressure,” he said. “It will escape. It’s guaranteed that the virus is going to mutate and escape all of the vaccines we’re trying to create.”If it does, he said Sorrento will be ready to rapidly deploy its DNA-based countermeasure. 4223

SAN DIEGO (KGTV) -- The leader of a San Diego motorcycle gang pleaded guilty Tuesday to participating in a scheme to seal dozens of Jeep Wranglers in San Diego County. Jimmy Josue Martinez, a leader of the Hooligans motorcycle gang, pleaded guilty Tuesday, admitting to participating in the scheme. According to court records, the gang is responsible for the theft of more than 150 of the vehicles since 2014, totaling about .5 million. Records show that the Hooligans used high-tech methods to disable security systems and steal the Jeeps before taking them to Tijuana to be sold or stripped for parts. RELATED: Three arrested, 6 sought in San Diego Jeep Wrangler theft ringAs part of the plea agreement, Martinez admitted to stealing the Jeeps in Pacific Beach, Serra Mesa, Chula Vista, Mission Valley, Ocean Beach, Hillcrest and North Park. Martinez and members of his crew would obtain the vehicle identification number in advance before getting secret key codes which allowed them to create a duplicate key for a particular Jeep. “The joy ride is over for Mr. Martinez,” said U.S. Attorney Robert Brewer. “These thefts were audacious and sophisticated and created hassle and heartache for scores of Jeep owners. I congratulate prosecutors Andrew Galvin and Joseph S. Green, the FBI and members of the Regional Auto Theft Task Force for putting together a strong case against a gang that, unfortunately, has lived up to its name.”Along with Martinez, eight other members of the gang were charged in a grand jury indictment in 2017. Of the nine charged, six have pleaded guilty and three are fugitives. 1616

SAN DIEGO (KGTV) - Surgeons at UC San Diego are using new technology that offers more options for patients who have complex thoracoabdominal aortic aneurysms. UC San Diego Health System is the first on the West Coast to use Dynamic Morphology Correction, a type of 3D imaging. It allows surgeons to compare scans taken before the procedure to real-time pictures during the surgery.Dr. Mahmoud Malas, Chief of Vascular and Endovascular Surgery at UC San Diego, says this type of technology uses minimal iodine contrast which lessens the chance of kidney problems for 25 percent of patients dealing with aneurysms.The data from this technology helps surgeons across the country.Dr. Malas adds, " They create prediction models that helps future surgeons perform procedures more accurately." 795

SAN DIEGO (KGTV) — The circus comes to San Diego this weekend in a pair of fun events and, of course, the craft beer and spirits are flowing elsewhere.Circus Vargas brings the big top back to Mission Valley for a weekend of acrobatic and astounding acts by circus performers. Chula Vista also hosts Circus in the Park with shows and workshops with performers with Fern Street Circus.Carlsbad's Flower Fields open for business this weekend, with their 50-acre display of beautiful Ranunculus flowers in bloom for the spring.The Mission Valley Craft Beer and Food Festival serves up delicious craft beers and food with a bacon twist from independent brewers and local chefs. The Mariachi Fest also pairs dazzling mariachi and folklórico performances with taco and tequila tastings in Escondido.THURSDAYCircus VargasWhere: Westfield Mission Valley; Cost: - Take your kids to the Big Top for a weekend packed with circus action as Circus Vargas hits Westfield Mission Valley. Acrobats, daredevils, and flying trapeze artists will perform to audiences' delight, recreating circus feats from the past for a new audience.Museum MonthWhere: Various locations; Cost: Prices vary(Thursday - Saturday) Throughout the month of February, San Diegans and visitors can pick up a special, free pass to save 50 percent at more than 40 museums throughout the city. Museums like the Fleet Science Center, Maritime Museum, San Diego Air & Space Museum, Natural History Museum, and many more are participating in the special month.FRIDAYKuumbaFestWhere: San Diego Repertory Theatre; Cost: - 5KuumbaFest brings three days of African-American culture, expression, and heritage to San Diego with traditional art, performances, educational workshops, a marketplace and health fair, Gospel concert, guest speakers, and more in celebration of our African-American community. Illumination: 21st Century Interactions with Art + Science + TechnologyWhere: San Diego Art Institute; Cost: FreeThe San Diego Art Institute hosts a free exhibit featuring an interactive show created by 26 artists. Guests will experience art through light, sound, metal, textiles, soundscapes, and more. The exhibits will walk visitors through issues like climate change, global health, and sustainability through art.SATURDAYMission Valley Craft Beer & Food FestivalWhere: SDCCU Stadium; Cost: - Enjoy sips and eats from dozens of independent San Diego breweries and eateries at SDCCU Stadium. Entry gets ticket holders unlimited tasters of craft beer and spirits and eats from each food vendor. The event will join forces with Bacon Fest to deliver some mouthwatering combinations of bacon and bites to guests.Circus in the ParkWhere: Chula Vista Bayfront Park; Cost: FreeChula Vista hosts a free day of activities for families during Circus in the Park. Exciting acts from Fern Street Circus, like jugglers and acrobats, will entertain crowds. Circus experts will also hold interactive workshops around hooping and tightwire activities, and face painting and photos booths.Leap Day CelebrationWhere: The Old Globe Theater; Cost: FreeHead over to Balboa Park where performers will stage a dance-of at the Old Globe Theater plaza. The fun starts at 11 a.m. with dance troupe performances and continues with workshops and dance competitions.SUNDAYMariachi FestivalWhere: California Center for the Arts, Escondido; Cost: - 0Take in the traditional sounds and sights of the Grammy-winning Mariachi Divas de Cindy Shea and folklórico dancers from Tierra Caliente Academy. Attendees can also spend the day at the festival's Tacos & Tequila reception, where they can sample spirits and participate in a silent auction.TinyFest CaliforniaWhere: Del Mar Fairgrounds; Cost: - Del Mar Fairgrounds will host several ideas in the world of "tiny homes" during TinyFest, featuring the latest in tiny living options, expert speakers, workshops for guests, and festival music and foods.Carlsbad Flower FieldsWhere: The Flower Fields; Cost: - Sunday is opening day for the Carlsbad Flower Fields this season! Peruse through 50 acres of beautiful variations of Ranunculus flowers, an artists garden, floral displays, and more. 4213