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LOS ANGELES, July 18 (Xinhua) -- U.S. scientists have proven that oncogenes can change normal cells into stem-like cells, paving the way to a safer and more practical approach to treating diseases like multiple sclerosis and cancer with stem cell therapy.In a collaborative study, researchers from the Keck School of Medicine of the University of Southern California (USC), and the Children's Hospital of Orange County (CHOC) in California and Good Samaritan Hospital Medical Center in New York have successfully converted human skin cells into brain cells by suppressing the expression of p53, a protein encoded by a widely studied oncogene. This suggests that p53 mutation helps determine cell fate -- good or bad -- rather than only the outcome of cancer.Oncogenes are generally thought to be genes that, when mutated, change healthy cells into cancerous tumor cells.Study findings were appearing Monday on the website of the American Association for the Advancement of Science (AAAS)."The reality may be more complicated than people think," said Jiang F. Zhong, Ph.D., assistant professor of pathology at the Keck School. "What is a stem cell gene? What is a cancer gene? It may be the same thing.""When you turn off p53, people think the cell becomes cancerous because we tend to focus on the bad thing," Zhong said. "Actually, the cell becomes more plastic and could do good things, too. Let's say the cell is like a person who loses his job (the restriction of p53). He could become a criminal or he could find another job and have a positive effect on society. What pushes him one way or the other, we don't know because the environment is very complicated."Stem cells can divide and differentiate into different types of cells in the body. In humans, embryonic stem cells differentiate into three families, or germ layers, of cells. The reasons why and how certain stem cells differentiate into particular layers are not clearly understood. However, from those layers, tissues and organs develop. The endoderm, for example, leads to formation of the stomach, colon and lungs, while the mesoderm forms blood, bone and heart tissue. In its study, Zhong's team examined human skin cells, which are related to brain and neural cells from the ectoderm.When p53 was suppressed, the skin cells developed into cells that looked exactly like human embryonic stem cells. But, unlike other man-made stem cells that are "pluripotent" and can become any other cells in the body, these cells differentiated only into cells from the same germ layer, ectoderm."IPSCs (induced pluripotent stem cells) can turn into anything, so they are hard to control," Zhong said. "Our cells are staying within the ectoderm lineage."Zhong said he expects that suppressing other oncogenes in other families of cells would have the same effect, which could have critical significance for stem cell therapy. Future research should focus on determining which genes to manipulate, Zhong said.The study is slated to appear in the Proceedings of the National Academy of Sciences later this month, according to AAAS.

BEIJING, July 25 (Xinhuanet) -- Apple is planning a third, even larger Shanghai store, as well as dozens of other stores throughout China, to cope with huge crowds at its flagship store and a branch, according to media reports Monday.Apple says its Chinese outlets -- two in Beijing and two in Shanghai -- are the four most heavily trafficked Apple stores in the world. They also generate the most revenue. Apple’s push into China shows the depth of the country’s fast-growing economy, and shows that with products not so easy to counterfeit, Chinese consumers are willing to pay a premium.For the first three quarters of Apple’s fiscal year, revenue in China and its Taiwan, Hong Kong was 8.8 billion dollars -- six times that of a year earlier. China has become the second-largest market, after the United States, for apps that run on the smartphone and tablet, according to Distimo, a Dutch company that tracks the popularity of apps.In addition, Apple has been eager to team up with state-run telecom companies, which looks after mobile phone subscriptions.

WASHINGTON, June 6 (Xinhua) -- A new University of Missouri study shows that the exposure to the controversial chemical Bisphenol A (BPA) through diet has been underestimated by previous lab tests.The findings were published on Monday in Environmental Health Perspectives.In the study, researchers compared BPA concentrations in mice that were given a steady diet supplemented with BPA throughout the day, compared to the more common lab method of single exposure, and found an increased absorption and accumulation of BPA in the blood of the mice.The authors continuously exposed the mice to BPA through their feed, which is considered the primary route of exposure to this chemical in animals and humans. In previous studies examining the effects of BPA, mice were exposed to BPA only through a one-time administration.Following the exposure through the diet, a significantly greater increase in the active form of BPA, which is the greatest threat as it is the form that can bind to sex steroid receptors and exert adverse effects, was absorbed and accumulated in the animals."People are primarily and unknowingly exposed to BPA through the diet because of the various plastic and paper containers used to store our food are formulated with BPA," said Cheryl Rosenfeld, associate professor in biomedical sciences and corresponding lead author. "We know that the active form of BPA binds to our steroid receptors, meaning it can affect estrogen, thyroid and testosterone function. It might also cause genetic mutations. Thus, this chemical can hinder our ability to reproduce and possibly cause behavioral abnormalities that we are just beginning to understand."The study notes that more than eight billion pounds of BPA are produced every year, and more than 90 percent of people in the United States have measurable amounts of BPA in their bodies."When BPA is taken through the food, the active form may remain in the body for a longer period of time than when it is provided through a single treatment, which does not reflect the continuous exposure that occurs in animal and human populations," said Rosenfeld. "We need to study this further to determine where the ingested BPA becomes concentrated and subsequently released back into the bloodstream to be distributed throughout the body."

SAN FRANCISCO, June 8 (Xinhua) -- Facebook Inc. will be probed by European Union (EU) regulators over its latest facial recognition feature rolling out worldwide, U.S. media reported on Wednesday.The feature, called Tag Suggestions, uses face recognition software to match users' new photos to other photos they are tagged in. It groups similar photos together and suggests the name of the friend in the photos.Facebook rolled out the feature in the United States late last year, where users can opt out of the feature by going to their private settings. But Facebook switched it on by default without telling users first when it became available on Tuesday in countries outside of the United States.A group of privacy watchdogs from 27 EU nations will study the measure for possible rule violations, a Luxembourg official of Article 29 Data Protection Working Party told Bloomberg. The Working Party, an independent EU advisory body on data protection and privacy, comprises the data protection regulators of all the 27 EU member states."Tags of people on pictures should only happen based on people' s prior consent and it can't be activated by default," said the Luxembourg official, Gerald Lommel. He noted that such automatic features "can bear a lot of risks for users" and the European data- protection regulators will "clarify to Facebook that this can't happen like this."Authorities in Britain and Ireland said they are also looking into the new function on Facebook. The British Information Commissioner's Office told Bloomberg that "the privacy issues that this new software might raise are obvious," saying it is "speaking to Facebook" about the issue.Facebook has been under scrutiny by EU regulators for several privacy concerns, such as users' default settings and how the company uses the information collected from its social network website.

CANBERRA, Sept. 23 (Xinhua) -- A genetic study on Friday found Aboriginal Australians are descended from the first people to leave Africa up to 75,000 years ago.Researchers from the University of Western Australia, Murdoch University and an international team analyzed genetic material of a 100-year-old West Australian Aboriginal man's hair, and found he was directly descended from a migration out of Africa into Asia.The study revealed that Australian Aboriginal ancestors split from the first modern human populations to leave Africa, between 64,000 and 75,000 years ago, at least 24,000 years before other human migrations.According to Dr. Joe Dortch, an archaeologist at the University of Western Australia, the discovery rewrites the history of the human species by confirming humans moved out of Africa in waves of migrations rather than in one single out-of-Africa diaspora.It also rewrites the story about how Aborigines arrived in Australia some 50,000 years ago."So far there are no [archaeological] sites that are over 50, 000 years old so it puts a time limit on that and focuses our future efforts," he said in a statement released on Friday.Dr. Dortch believes the finding will foster a sense of pride in modern Australian Aborigines."No-one else in the world can say 'I am descended from people who have been here 75,000 years'."Associate Professor Darren Curnoe, leader of the Human Evolutionary Biology Lab in the School of Biological, Earth & Environmental Sciences at the University of New South Wales, said the study powerfully confirms that Aboriginal Australians are one of the oldest living populations in the world, certainly the oldest outside of Africa."Australians are truly one of the world's great human populations and a very ancient one at that, with deep connections to the Australian continent and broader Asian region. About this now there can be no dispute," he told Xinhua in an email note.Meanwhile, Professor Alan Cooper, Director of the Australian Centre for Ancient DNA (ACAD) at the University of Adelaide, said while this is a major step forward, the key unresolved question remains the unique story of Aboriginal history within Australia, such as what has happened in those 50,000 years of life in the harsh Australian environment."Unfortunately, the information from a single individual tells us very little about this fascinating, and critically important part of human history. Aborigines are one of the oldest continuous human populations outside Africa, as they note in the paper, and due to the geographic isolation and limited archaeological records remain one of the most mysterious chapters in human history," he told Xinhua on Friday.The study is published on Friday in the journal Science.Indigenous Australians are the original inhabitants of the Australian continent and nearby islands. They together make up more than 2.5 percent of Australia's population.