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In hospitals, one bacterial species is becoming increasingly tolerant to the alcohols used in hand sanitizers, according to research published Wednesday in the journal Science Translational Medicine.Globally, hospitals use isopropyl or ethyl alcohol-based disinfectants, such as hand rubs, to prevent patients from becoming sick from many germs. These are the same active ingredients found in hand sanitizers available for personal use and at schools -- but that doesn't mean people should give up on them.The bacterium Enterococcus faecium resides in our guts, but if encountered in a hospital, it can cause various complicated infections affecting the abdomen, skin, urinary tract and blood. This particular bug is a member of the Enterococci family, which ranks as the fourth and fifth leading cause of sepsis, a life-threatening bloodstream infection, in North America and Europe, respectively.Many hospital-acquired infections have decreased or been kept in check by Australia's strict hygiene practices that rely on alcohol-based hand sanitizers. Yet drug-resistant E. faecium infections have increased in Australian hospitals over time, according to the study authors.This alarming pattern prompted them to investigate whether E. faecium might be developing resistance to the alcohols used in hand rubs. 1343

It's not too hard to spot massive housing projects being built around San Diego County right now.But they may not be enough to provide little relief to the rising rents and home prices around the region.A recent report from the San Diego Housing Commission said the city would need to build on average as many as 22,000 housing units per year for the next decade. But in 2017, only 10,000 units were authorized countywide."It's not so much that there is resistance to it, it's just the fact that it's hard to do," said Jeff Stevens, chair of the Mira Mesa Community Planning Group. "If you have to tear something down in order to build something else, it takes time and money."Some of the city's larger projects are in Mira Mesa - where Casa Mira View will have about 2,000 apartments when complete.And to the west at Hansen's Aggregates, a quarry that runs through Carroll Canyon, Shea and Lennar are planning to build what's called 3 Roots. The complex would have 1,800 units - including 186 single-family homes, 981 condos, and 633 apartments (180 of which will be affordable). The complex is about to go through environmental review. Still, residents are already expressing concerns over impacts like traffic."I want people to have affordable housing, that's very important. And also we want the contractors, subcontractors to have jobs, and growth is always important. But they need to think it through first before they do it," said John Svelan, a longtime Mira Mesa resident. ,Stevens said his board has reacted positively to 3 Roots, which would extend Carroll Canyon road. Another complex is being proposed over at Vulcan Materials for about 4,500 homes, but that's further away. The city of San Diego recently approved a series of development incentives, including density bonusses for micro-units near transit areas, that it hopes spurs more building. Lynn Reaser, chief economist at Point Loma Nazarene University, said it may take 15,000 new units per year just to stabilize the market. Meanwhile, Alan Gin, economist at the University of San Diego, noted that the region added 27,000 new jobs in the last year, increasing the demand for housing.    2220

It's looking like at least one? — if not more — American tech giants may soon find themselves worth more than trillion dollars. That's a lot of zeroes. A dozen in fact.Apple is in the lead right now. Thanks to strong demand for its new iPhones, the company now has a market value of about 0 billion.The stock only needs to go up another 10% for Apple to top trillion.But even if Apple gets to the trillion dollar mark first, it may soon have company. Apple rival Alphabet -- aka Google -- has a market cap just shy of 0 billion.Amazon and Microsoft are also nipping at the heels of Apple and Google. Both of the Seattle-based tech titans are worth more than 0 billion.And these two companies seem to have more momentum than Apple and Google, whose stocks are up about 6% this year.In fact, GBH Insights analyst Daniel Ives wrote in a report Monday that he thinks Amazon could get to a trillion dollar valuation within 12 to 18 months.Amazon's stock has soared 30% this year thanks to impressive growth in its core e-commerce business as well as gains from last year's acquisition of Whole Foods and strength in its AWS cloud division.Microsoft has also benefited from growth in its cloud business. The stock is up 11% this year and is not far from a record high.If the four biggest tech companies all hit the trillion dollar milestone relatively soon, they eventually may wind up being joined by a few other tech giants -- and a much older school conglomerate as well.Facebook, Chinese e-commerce giant Alibaba and Chinese gaming and social networking kingpin Tencent are all worth about half a trillion dollars. So is Warren Buffett's Berkshire Hathaway.There's also the possibility that none of these tech companies will be the first to top the magical trillion dollar level.That's because oil giant Saudi Aramco is hoping to go public sometime this year -- and it is expected to be valued somewhere between .5 trillion and trillion. 1968

Investigators for special counsel Robert Mueller have recently been asking witnesses about Donald Trump's business activities in Russia prior to the 2016 presidential campaign as he considered a run for president, according to three people familiar with the matter.Questions to some witnesses during wide-ranging interviews included the timing of Trump's decision to seek the presidency, potentially compromising information the Russians may have had about him, and why efforts to brand a Trump Tower in Moscow fell through, two sources said.The lines of inquiry indicate Mueller's team is reaching beyond the campaign to explore how the Russians might have sought to influence Trump at a time when he was discussing deals in Moscow and contemplating a presidential run.Mueller was appointed to investigate Russian meddling in the 2016 campaign. The President claims that any investigation of his family's finances would be a breach of the special counsel's mandate.Two of the sources said they do not know from the questions asked whether Mueller has concrete evidence to indicate wrongdoing."You ask everything even if you don't think it's credible," one of the sources said, adding, "the allegations are out there, and it was checking the box."The special counsel's office, an attorney for the President and the Trump Organization all declined to comment for this story.Questions about Trump's entry into the campaign 1428

In the shadow of the Capitol dome Tuesday was a sobering display of thousands of pairs of shoes, organized neatly across the grass said to represent children who have died in the US from gunshot wounds since the Newtown elementary school massacre in 2012.The global advocacy group Avaaz has been collecting donated pairs of shoes for two weeks and early Tuesday morning lined them up one by one, 18 inches apart, in roughly 80 rows on the Capitol lawn, as Congress continues to sort through a debate over gun violence and school safety."Shoes are individual. They're so personal. There are ballet slippers here and roller skates. These are kids," said Nell Greenberg, the campaign director for Avaaz.The display feature 7,000 pairs of shoes. To arrive at that figure, the group cited a 2017 report from the American Academy of Pediatrics using data from the Centers for Disease Control and Prevention that found nearly 1,300 children die from gunshot wounds in the US every year. Avaaz then tallied up the estimated number since the December 2012 shooting at Sandy Hook Elementary School.Organizers say shoes were donated from across the country and stored in a Washington, DC, warehouse until Tuesday. Among those who donated were family members who've lost loved ones to gun violence, such as Tom Mauser, who lost his son in the Columbine school shooting and traveled from Colorado to hand deliver his son's shoes for the display."My son wore the same size shoes as me. I discovered that after he died and that became a big symbol for me, that I could walk in his shoes," said Mauser, who has since become an advocate for stricter gun control.Mauser came to Washington with two pairs of his son's size 10.5 shoes. He placed one pair in the display and wore the other pair -- some gray and black Vans that Daniel was wearing the day he was killed. "That's usually what I wear," Tom Mauser said.Shoes from celebrities like actress Bette Midler and comedian Chelsea Handler were also seen on the grass.The display comes nearly one month after a gunman killed 17 people at a Parkland, Florida, high school, triggering a vocal movement led by student activists demanding more gun control and school safety.The House of Representatives votes Wednesday on a bill to increase security at school, and while it's expected to pass, many Democrats are upset the package doesn't include gun control measures. Also on the Capitol lawn Tuesday, six senators gathered for a news conference to support the Senate version of the House bill, also known as the STOP School Violence Act. The Senate version does not contain gun measures."This is about schools but it's not just about schools," Republican Sen. Marco Rubio of Florida, who is a co-sponsor of the Senate bill, told reporters. "When someone is determined that they're going to commit an act of violence, it could be in a school, it could be in a mall, it could be in a movie theater, it could be in an airport, it could be at a stadium. So, what we're really focused on here more than anything else is identifying the people that are going to commit a violent act irrespective of where they're going to commit it and stopping them before they do it."The Senate Judiciary Committee will hold a hearing Wednesday on the Parkland shooting and failures by FBI and law enforcement to recognize warning signs exhibited by the gunman before the massacre. The hearing is also expected to focus on a spate of recent gun control legislation that's been introduced by members on both sides of the aisle.Gabrielle Weiss, a 24-year-old volunteer who helped lay out the shoes Tuesday morning, said she wanted to help keep the issue of gun violence alive in the news cycle after seeing it fade after past shootings."I was happy that we were doing this a while after (the Florida shooting) just to keep beating the drum," said Weiss. "These kids that were lost in Florida, they aren't just headlines. They're real people that could have been standing there today." 4010