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The first experimental COVID-19 vaccine in the U.S. is on track to begin a huge study next month to prove if it really can fend off the coronavirus, while hard-hit Brazil is testing a different shot from China.Where to do crucial, late-stage testing and how many volunteers are needed to roll up their sleeves are big worries for health officials as the virus spread starts tapering off in parts of the world.Moderna Inc. said Thursday the vaccine it is developing with the National Institutes of Health will be tested in 30,000 people in the U.S. Some will get the real shot and some a dummy shot, as scientists carefully compare which group winds up with the most infections.With far fewer COVID-19 cases in China, Sinovac Biotech turned to Brazil, the epicenter of Latin America’s outbreak, for at least part of its final testing. The government of S?o Paulo announced Thursday that Sinovac will ship enough of its experimental vaccine to test in 9,000 Brazilians starting next month.If it works, “with this vaccine we will be able to immunize millions of Brazilians,” said S?o Paulo′s Gov. Joao Doria.Worldwide, about a dozen COVID-19 potential vaccines are in early stages of testing. The NIH expects to help several additional shots move into those final, large-scale studies this summer, including one made by Oxford University that’s also being tested in a few thousand volunteers in Brazil.There’s no guarantee any of the experimental shots will pan out.But if all goes well, “there will be potential to get answers” on which vaccines work by the end of the year, Dr. John Mascola, who directs NIH’s vaccine research center, told a meeting of the National Academy of Medicine on Wednesday.Vaccines train the body to recognize a virus and fight back, and specialists say it’s vital to test shots made in different ways — to increase the odds that at least one kind will work.Sinovac’s vaccine is made by growing the coronavirus in a lab and then killing it. So-called “whole inactivated” vaccines are tried-and-true, used for decades to make shots against polio, flu and other diseases — giving the body a sneak peek at the germ itself — but growing the virus is difficult and requires lab precautions.The vaccine made by the NIH and Moderna contains no actual virus. Those shots contain the genetic code for the aptly named “spike” protein that coats the surface of the coronavirus. The body’s cells use that code to make some harmless spike protein that the immune system reacts to, ready if it later encounters the real thing. The so-called mRNA vaccine is easier to make, but it’s a new and unproven technology.Neither company has yet published results of how their shots fared in smaller, earlier-stage studies, designed to check for serious side effects and how well people’s immune systems respond to different doses.Even before proof that any potential vaccine will work, companies and governments are beginning to stockpile millions of doses so they can be ready to start vaccinating as soon as answers arrive.In the U.S., a program called “Operation Warp Speed” aims to have 300 million doses on hand by January. Under Brazil’s agreement with Sinovac, the Instituto Butantan will learn to produce the Chinese shot.___AP journalist Marcelo Silva de Sousa contributed to this report.___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 3499

The first person known to be cured of HIV infection, Timothy Ray Brown, has died. He was 54.Brown was long known as “the Berlin patient” for where his historic treatment took place.He died Tuesday at his home in Palm Springs, California, according to his partner.The cause was a return of the cancer that originally prompted the unusual bone marrow and cell transplants Brown received in 2007 and 2008, which for years seemed to have eliminated both his leukemia and HIV, the virus that causes AIDS.His case inspired more research toward a cure, something that many scientists had thought impossible until his example proved that it was. 645

The Florida recount deadline passed on Thursday afternoon with at least one of the state's largest counties unable to complete the task.Florida law stipulates that any races with margins outside 0.25% can now be certified by law. Races that are still within that range will head to a manual recount of overvotes and undervotes to be completed by Sunday at noon.Election boards in every Florida county have been using voting machines to recount ballots this week, with some of the larger counties working all day and night. There are currently three statewide races -- the contests between Democratic Sen. Bill Nelson and Republican Gov. Rick Scott for Senate; Democratic Tallahassee Mayor Andrew Gillum and Republican former Rep. Ron DeSantis for governor; Republican Matt Caldwell and Democrat Nikki Fried for agriculture commissioner -- that were within the .5% margin required for a statewide machine recount.The fiery race between DeSantis and Gillum is the most likely to come to a formal end. The Republican led by roughly 33,000 votes after the initial count. Gillum, who conceded the race on election night before taking back his concession a few days later, tweeted on Wednesday, "I believe that we win," hinting that he believes the gap could narrow. But there is no evidence yet that he made up enough ground to extend the fight.The two other contests are significantly closer and appear likely to head to a hand recount. Nelson and Scott are divided by roughly 12,000 votes, which is why most of the flurry of recent legal action has been spun out of their race.Palm Beach County missed the deadline, which a court ruled on Thursday afternoon will not be extended.Hours before the cutoff, a federal judge in Tallahassee rejected a Democratic motion to extend the deadline beyond 3 p.m., meaning last week's unofficial count out of Palm Beach County will likely stand.Nelson's campaign and the Democratic Senatorial Campaign Committee argued that deadlines for both the machine and subsequent hand recounts should be lifted for however long is determined is necessary by the counties."The Florida legislature chose to define emergency narrowly -- only as an event that results or may result in substantial injury or harm to the population or substantial damage to or loss of property," Judge Mark Walker wrote in explaining his decision. "The emergency exception does not apply in this case, where the delay is the result of outdated and malfunctioning vote-counting technology."Palm Beach County has been hampered repeatedly by faltering machinery and shoddy infrastructure.Susan Bucher, the county's supervisor of elections, told reporters on Thursday she takes "full responsibility" if the county fails to recount before today's deadline."As a supervisor I take full responsibility. That's my job. It was not for lack of human effort ... it was so incredible, and I thank everybody who participated," she told CNN's Rosa Flores during a press conference.Bucher told reporters a little more than 24 hours before the cut-off, slated for 3 p.m. on Thursday, that she was in "prayer mode." On Sunday, hours after the recount began, Bucher said that completing the process would be "impossible."CNN has not called the Senate race between incumbent Nelson and his challenger, Republican Gov. Rick Scott. Before the recount began, Scott led Nelson by around 12,000 votes. The margin in the gubernatorial race between Republican Ron DeSantis and Democrat Andrew Gillum, which is also subject of the recount, is larger, with DeSantis up on Gillum by around 33,000 votes.Bucher's worries were compounded on Tuesday when the county's old and overheated machines malfunctioned, forcing officials to start their recount of early votes from scratch. By Wednesday, the already distant hopes of an on-time finish seemed to be slipping away.CNN observed long stretches of inaction on the floor of the cavernous facility which has been occupied by reporters, lawyers and operatives from both parties, and volunteers who have been working -- when the hardware complies -- day and night."It's an unusual request to make of your staff. You know, can you leave your kids behind, stay here and I'll feed you sub sandwiches and pizza and you'll work your brains out," Bucher said on Wednesday. "We're trying to meet a deadline that really reasonably shouldn't be there."Democrats agree -- and will make their case in a federal court in Fort Lauderdale on Thursday morning at 9 a.m.Lawyers for Nelson's campaign and the Democratic Senate campaign arm are suing to allow all 67 counties the time they say is required to complete their recounts. According to a legal filing, the Democrats will argue that enforcement of the current deadlines, including another on Sunday at noon for a potential hand review, would violate the constitutional rights of "thousands of Florida voters at risk of disenfranchisement in the 2018 general election."If their suit is rejected and Palm Beach County fails to complete its work on schedule, the state is expected to certify the unofficial results as initially reported ahead of the recount.A spokeswoman for the Florida Department of State told CNN on Sunday that Florida law does not give the secretary of state the authority to grant extensions.Palm Beach County GOP Chairman Michael Barnett told CNN on Sunday afternoon that a blown deadline would be "good news for Republicans, because our candidates (for Senate and governor) are ahead.""If they're not able to meet the deadline, the secretary of state of Florida may go ahead and certify the elections for our candidates," Barnett said. "In that case, you can bet your butt there will be lawsuits filed everywhere."Barnett, who was inside the facility along with Democrats early on in the recount, was critical of the infrastructure there from the start."It's an outdated process," he said. "The machinery is old. They don't have enough updated machinery to go through all the ballots to run one election, let alone all three statewide races."As of 4 p.m. Wednesday, at least 48 of Florida's 67 counties had finished their recounts. Every one of them reached by CNN -- with the exception of Palm Beach -- expressed confidence they would get in under the wire.In a different lawsuit, a federal judge in Florida ruled Thursday that the state must give voters whose mismatched signatures disqualified their provisional and mail-in ballots until Saturday at 5 p.m. ET to correct those signature problems -- extending the deadline by two days. 6536

The Catholic Diocese of Youngstown released a list of names Tuesday of clergy personnel credibly accused of sexual abuse of a minor and who were reported to authorities.After a thorough investigation, Bishop George V. Murray, S.J., accepted the accusations as credible, according to the news release sent by the diocese.“I am very sorry that the Church has failed to act aggressively to eliminate this evil.  I humbly ask forgiveness from the victims and their families for the grave mistakes the Church has made," said Bishop Murray in the release.Through the investigation, Bishop Murray said, “that as painful as the process of voluntary disclosure of names is for parishioners where these men served, this is one way that we can offer support and dignity to the survivors of clergy sexual abuse and their families.”The following is a list of clergy members who had credible, substantiated allegations of sexual abuse of a minor made against them, according to the Catholic Diocese of Youngstown: 1022

The creator of Jelly Belly is diving into a new brand of the iconic candy. According to Business Insider, Jelly Belly inventor David Klein is launching Spectrum Confections, which will sell CBD-infused jelly beans. Business Insider reports that the candies will come in 38 flavors, including pi?a colada, strawberry cheesecake and roasted marshmallow. Each bean will reportedly contain 10 milligrams of CBD. Jelly Belly itself, which was created by Klein in the 70s, isn’t involved in the new creation. CBD is the non-psychoactive component of marijuana used for treating pain and inflammation, according to Medical News Today. 636