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SAN DIEGO (KGTV) — As the world waits for a vaccine against the coronavirus, two San Diego biotechs are teaming up to develop a nasal spray using designer antibodies cloned from COVID-19 survivors.About 70 companies worldwide are working on therapies for COVID-19 using cloned antibodies, according to an estimate by the International AIDS Vaccine Initiative. A few of these treatments, known officially as monoclonal antibody therapies, have advanced to clinical trials.Most require an injection, but San Diego-based Diomics and its partner Active Motif, based in Carlsbad, are developing a once-a-day spray that could be easily self-administered.Early research suggests the coronavirus primarily enters the body through the nose. The spray, called Dioguard, is designed to coat the lining of the nasal cavity with cloned antibodies that are held in place for 24 hours or more using a proprietary polymer material developed by Diomics.Diomics CEO Anthony Zolezzi said he believes the spray “holds the key to allowing many aspects of life to resume until the day comes when there’s an effective vaccine in widespread use.”Diomics is also developing two tests for COVID-19 antibodies using its polymer beads, including a device that looks like a nicotine patch that is designed to monitor for infections for a week or more.RELATED: How a dot on your forearm could be the future sign of COVID immunityActive Motif is providing the cloned antibodies for the nasal spray. With a lab in Shanghai and other relationships in China, the Carlsbad company was able to clone antibodies from 11 Chinese survivors in February, before the World Health Organization declared a pandemic.When the company started the cloning project, they thought the virus would probably disappear in three to six months, said Active Motif CEO Ted DeFrank. “Then people started realizing, no this is going to be with us for a while.”The plasma from the 11 Chinese patients contained thousands of antibodies, and scientists with Active Motif set about selecting the one that was most effective, dubbed 414-1. The company says it can neutralize SARS-CoV-2 virus particles with 98 percent effectiveness.Monoclonal antibodies have some similarities to convalescent plasma, which is a complex cocktail of antibodies and other immune molecules drawn from the blood of recovered patients. One of the key differences is that cloned antibodies can be mass produced in a lab.Cloned antibodies have been used in treatments for more than 30 years, primarily for cancer. One such treatment famously helped former U.S. President Jimmy Carter beat melanoma.But of the more than 100 monoclonal antibody therapies licensed for use, only seven are for communicable diseases, according to IAVI.Historically, the treatments have been expensive and difficult to produce, but Diomics said it’s targeting a price of about a spray for Dioguard, roughly per bottle.“We do not want to have huge profits from a pandemic, that’s just wrong,” Zolezzi said. “We’re going to price this as effectively as we can for the masses. We want to get this out to the masses.”Animal testing is about to begin and the companies said they hope to progress to human trials soon. Their goal is to release the spray in early 2021, when a vaccine may be on the market but not yet widely available.If the spray works, it could be adapted to other viruses to help fight future pandemics, Zolezzi said."That’s our real goal," Zolezzi said. "That we never get caught flat-footed like this time." 3526

SAN DIEGO (KGTV) - Charles Schwab is the latest large investment firm to offer fractional stocks as a way to get more people to invest.The move puts more high-dollar, blue chip stocks within reach for younger customers."It's a big win to consumers in general," says Steven Fox, the owner of Next Gen Financial Planning. "That's particularly helpful for younger investors because they typically tend to have smaller accounts."A recent report says that 66% of millennials say they're afraid of the stock market. Fox thinks it's because that generation watched their parents go through multiple downturns and were turned off by its volatility.But, Fox says fractional stocks, and other new ideas from large companies are enticing more people to invest. He says many firms are starting to offer perks like zero-commission trades, fractional stocks, and on-line based accounts to help people save money and invest more."It may only be 1%, but for a lot of people over a long period of time, as you account grows more and more, that 1% can mean a difference of tens or hundreds of thousands of dollars that you would have available to pull out later in life."Fox says it also helps people keep a more diverse portfolio. He says this is the start of a shift to more direct indexing, where investors will be able to use fractional stocks to create their own groups of investments, rather than buying pre-set mutual funds or indexes."You're gonna see more technology come out that makes it easy to do direct indexing and consumers are going to see more and more options here," says Fox. 1585

SAN DIEGO (KGTV) -- Crews were able to extinguish a fire in Clairemont Friday afternoon reportedly started by a crash. According to California Highway Patrol, the blaze started on Boyd Avenue near Genesee Avenue. San Diego Police say at 5:24, a suspect hit several vehicles on Balboa and Mount Alifan Drive before taking off. RELATED: Check today's San Diego County forecastThe suspect then lost a tire, creating sparks and starting the blaze. The suspect was later taken into custody. The fire sparked just as a Red Flag Warning in parts of San Diego County was allowed to expire. 590

SAN DIEGO (KGTV) - Another testing site is being added to San Diego County, and this one will be the closest to the U.S.-Mexico border so far for the region.The San Ysidro port of Entry’s PedWest crossing is one of the world’s busiest pedestrian international border crossings. Within the next two weeks, a testing site at that location will join the more than two dozen others across San Diego County. It will be an appointment-free, walk-up site. Officials expect 200 tests to be done daily there.Chicano Federation Chief Strategy Officer Roberto Alcantar said this is a step in the right direction as far as testing is concerned, but said there is still work to be done to help the Latino community.Related: San Diego County launches COVID-19 outreach campaign for LatinosHe said many in the Latino community are afraid of getting tests done because of the fear of a positive test.“Our community is nervous about losing their jobs, not being able to go to work, the real economic impact that comes from being positive and feeling that that might hinder them in a way,” he said.He added that this is a big-picture problem. The Latino community lacks affordable housing, forcing families to live in close quarters and increasing the risk of spreading the virus, and also forcing people to live across the border to find affordable housing. Many of these people are essential workers and need to continue to work to support their families, so they cross the border on a daily basis. This new site will help give them access to testing.“They’re having to cross the border every day. We’re hearing from workers that they’re spending 4-5 hours every day waiting just to cross,” said Alcantar.Alcantar also said that the new testing site will likely lead to more positive rates, as is expected with increased testing, and he worries about what that will do to the perception of the Latino community, which already has higher numbers than the rest. As of August 9, 62% of San Diego’s cases are Hispanic people, a community that makes up just 34% of the population. That number will likely continue to climb with another testing site in an area dominated by Spanish speakers. This, tied with a perception that people are carrying the virus from Mexico to the U.S., could be bad.“Our concern is that this will help push further that narrative that we have to have a testing site because the rates are coming from Mexico,” he said.The Chicano Federation has been working with UCSD to reach out to the Latino community and find out why they don’t want to get tested and also encourage them to get tested. They also have been working with the county and giving feedback on testing in the Latino community.San Diego County also launched a campaign at the end of July targeted at helping get resources and information to the Latino community about safety measures, testing resources and contact tracing. 2899

SAN DIEGO (KGTV) — Beautiful sunsets may be considered a common occurrence in San Diego but that doesn't make them any less special.While pretty much any spot in San Diego can be considered "the best place to see sunsets," there are some areas that capture the scene better.And yes, many of them are at the beach.RELATED: San Diego's?most picturesque spotsBut that's not to say there aren't great places elsewhere! So if you're ready to grab your camera or just observe with your eyes, here's where to enjoy a breath-taking sunset around the county:Sunset CliffsIt's in the name. Sunset Cliffs gives photographers and anyone peering out to sea nearly 180-degrees of sky meeting water to gaze at. And during a sunset, that can create some amazing viewings as colors are reflected off the waves.Balboa ParkAs San Diego's crown jewel, Balboa Park lends itself to beautiful scenes museums and landscaping with the city in the background. Drop in a sunset and those scenes seem to transform once your eyes hit the horizon.Lake CuyamacaThe Lake Cuyamaca area brings San Diego's routinely dry, East County landscape together with the calmness of the lake. Sunsets are reflected beautifully off the lake, while the dry brush and mountains on the horizon can split through, creating some stunning imagery.Temecula wine countryUp north, San Diego County's wine region creates a mesmerizing foreground to sunsets. Between the vines curling up and over one another, rays of sunlight break through.Oceanside HarborThere nothing quite like a shot of the sun peering over masts and sails from boats bundled together in a harbor. Though there may not be a lot of reflection of the water, there's plenty to stand in awe and observe. 1733

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