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SAN DIEGO (KGTV) — In some of the most severe cases of COVID-19, doctors are finding it’s not the coronavirus making people critically ill.It’s their own immune system, and a San Diego-based biotech company thinks it has an answer.La Jolla-based INmune Bio announced Tuesday it has FDA approval to begin a Phase 2 clinical trial on its inflammation fighting drug, Quellor.In many of the sickest COVID patients, doctors have noticed their blood is filled with high levels of immune proteins called cytokines. Cytokines act as messengers between cells and the virus can cause them to go haywire, setting off what’s known as a cytokine storm.In a cytokine storm, the body’s immune system starts to attack its own cells and tissues rather than the virus. During the Spanish Flu of 1918, many of the deaths were caused by cytokine storms.“You need to control the cytokine storm to keep patients from getting sick,” said INmune Bio’s CEO Dr. R.J. Tesi.There are several different types of cytokines. A drug undergoing testing in a federal trial with remdesivir targets a cytokine called beta interferon.The San Diego biotech’s drug Quellor suppresses a very specific cytokine called soluble tumor necrosis factor, which Dr. Tesi calls “the master cytokine” because of its role in triggering other immune proteins.Dr. Tesi said this particular cytokine may contribute to another troubling issue with COVID-19: blood clotting.“When they write the history of COVID-19, the clots are going to be the bad guy,” Dr. Tesi said. “These blood clots go off everywhere and they gum up the works. They make it so the lungs can't work. They make it so the kidneys can't work. They make it so the heart is screwed up. Make it so you have strokes.”INmune Bio, which is publicly traded but has just six full-time employees, is hoping its drug can address both the blood clots and the inflammation.The company plans to enroll 366 hospitalized COVID-19 patients for a Phase 2 trial to see if intervention with Quellor can keep people off ventilators and out of the ICU. 2053

SAN DIEGO (KGTV) — It's not the most family-friendly event in town, but it is one of San Diego's most time-honored bashes.The 66th Over-The-Line (OTL) World Championship returns to Fiesta Island Park for two weekends July 13 and 14, and July 20 and 21. The annual event, known for its color team names and characters, started locally in the 1950s and has since become a highlight of summertime in San Diego.What more can you ask for during the sweltering heat? Sunshine, brews, and a simple sport that everyone can follow. Well, it may not be that simple for newbies, but it's a quick lesson.RELATED: Ocean Beach summer tradition returns as 'David Buoy' is deployedHere's what to know:The batter and pitcher are on the same team. The batter's goal is to hit the ball into fair territory (over the line) without a fielder catching it. A hit includes any ball that lands in fair territory, if a fielder crosses over the line, or if a fielder drops the ball in fair or foul territory.If a batter connects with the ball but it does not cross the line, it can be saved and ruled a "no pitch" if the batter or pitcher are able to catch the ball before it hits the ground. Kind of like a redo pitch.An out is recorded when the ball fails to cross the line, a batter swings and misses, a fielder catches the ball in fair territory, a batter has two fouls, a player bats out of order, or if a pitcher or batter touch but do not catch a ball that falls short of the line.Nobody actually runs bases — at times, that's probably for the best — and three outs end each half of an inning just like baseball.To score:The third hit of a half-inning scores one run and each hit after that scores another run.A home run, which is when a ball lands past the last fielder without it being touched, scores a run and any hits before it. The hit count is then reset to zero.Anyone is free to spectate, but the Old Mission Beach Athletic Club (OMBAC) has a few guidelines. Participants and fans follow the "No Bs" of OTL, which include no bottles, no bowzers (dogs), no babies, and no battles (fighting.) RELATED: San Diego Airbnb experience transforms clients into mermaidsWhile the event is free, organizers warn that OTL is not the most appropriate and safe event for children due to crowds, language, booze, and the open sports setting.Before heading out, check traffic and weather conditions around the Mission Bay area. For more information on team registration, tickets, and parking visit the OMBAC website. 2497

SAN DIEGO (KGTV) — It looks like just another small apartment. Living room. Bedroom. Kitchen.But the apartment complex 10News toured is unlike any other. It's a solution for homelessness."People go into treatment, they get out, they relapse and the go back in and they get stuck in this thing we call the churn of in and out, and in and out of services."So Chris and Tammy Megison came up with a solution: Solutions for Change. The idea is to get families with children off the streets and into a program that would change their lives forever."We get them jobs right away, put them to work so they can learn the soft skills of working," Chris Megison said. "They're up at 5:30. Kids are fed and off to school. And now they're going to classes, they're going to work."Solutions for change works because of its motto, driven by accountability. It's a 1000 day program. Every client must have a job, and most work in the solutions aguaponic farm. They grow their own organic food, and what they don't eat they sell, and the proceeds go back into the program. "They're not looking to be a band-aid fix, they're looking to be a 'hand up' organization. They're not lowering the bar for people who find themselves in a pretty dark tragic place, they're trying to raise the bar and set people up for future success," San Diego County Supervisor Kristin Gaspar said.And since 1999, Solutions for Change has helped 900 families escape homelessness. People like Melissa Martinez and her children who not long ago were separated without a place to call home."It's put us all back under one roof. It's actually be a lot easier than I could have ever imagined, getting everybody to and from school, to and from work, we're really united and working as a team. So it's really just brought us tremendously closer," Martinez says."All we ask is, 'Would you grab one bootstrap and let us grab the other and let's do this thing called life,'" Megison says.To learn how to help Solutions for Change or donate, visit their website here. 2024

SAN DIEGO (KGTV) — Jalen McDaniels, San Diego State University basketball's sophomore forward, was accused of filming consensual sex acts with a classmate in 2016 without her knowledge and sharing it with friends, according to a civil lawsuit filed Wednesday in Washington.The civil suit alleges McDaniels recorded the intimate moments with an 18-year-old female student while they were both seniors at Federal Way High School near Tacoma, Wash.The lawsuit goes on to say while McDaniels later told the plaintiff about the unauthorized recordings and that he had shared it with his friends, she learned from other students that the video became widely circulated. When she confronted McDaniels, he explained he had gotten away with a similar incident involving another female student, according to the lawsuit.The plaintiff's attorney, Joan Mell, who filed the suit, wrote her client has suffered from several self-destructive behaviors as a result, including attempting suicide.SDSU is accused of wrongdoing in the lawsuit as well.Mell alleges in the lawsuit that SDSU was contacted by Washington police to provide them with McDaniels' phone number, but failed to do so. The suit says SDSU, instead, alerted former basketball coach Steve Fisher, who secured McDaniels a lawyer, and McDaniels refused to cooperate.The suit goes on to allege McDaniels' refusal to cooperate and, "that others concealed his wrongdoing prevented prompt criminal investigation and referral to the prosecutor's office for timely filing of criminal charges under Washington’s criminal offense of distribution of intimate images."In a statement, SDSU said there would be "no change in [McDaniels'] status at the university" at this time, after an investigation by Washington authorities resulted in no charges before McDaniels' enrollment at the school: 1837

SAN DIEGO (KGTV) — Max may look like most 5-year-olds, but a rare illness left him paralyzed from the shoulder to his wrist. Bending his arm on his own is impossible — until he puts on a new device designed to help him move.University of California, San Diego, engineering students Ethan and Marcos Serrano developed these "Iron Kid" arms over the last ten weeks after max's doctor at Rady Children's Hospital enlisted their help. Today is the first time Max and his family will be able to take the arms home. Dad, Ted Ng, says he and his wife have been in awe of this whole process."It's been really touching to have this come together," Ng said. "There's all kinds of robotic arms out there but none of them would really work for his condition."Grateful to see their son gain back some of his mobility. "It was kinda of like a miracle cause I didn't know how well it would work on him cause because as a child his limbs have a very specific shape," Ng added.And do more of the stuff 5-year-olds do, like pick stuff up, eat his favorite foods, or just play with his dad."It's really up to him to figure out how he wants to use this thing," Ng said. 1158