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WASHINGTON, April 25 (Xinhua) -- A class of drugs that shows promise in breast and ovarian cancers with BRCA gene mutations could potentially benefit colorectal cancer patients with a different genetic mutation, a new study from the University of Michigan Comprehensive Cancer Center finds.Working in cell lines from colorectal cancer patients, researchers found that the class of drugs called PARP inhibitors worked against tumors with mutations in the MRE11 gene.About 15 percent of all colorectal cancers have what's called microsatellite instability, a type of error in the DNA. About 82 percent of those tumors have the MRE11 gene mutation."This is a potential broader application for PARP inhibitors, beyond breast and ovarian cancer. This is a class of drug that's already shown safety in early clinical trials and now might benefit some colorectal cancer patients as well," says lead study author Eduardo Vilar-Sanchez, a hematology/oncology fellow at the university, in a statement.The study, which was published Monday in Cancer Research, also found that PARP inhibitors are even more effective when both copies of MRE11 were mutated. Each person carries two copies of each gene, which means mutations can occur in either one or both copies. The researchers suggest that PARP inhibitors could be targeted specifically to colorectal cancer patients who have two copies of the mutated gene.Researchers are planning a phase I clinical trial to look at using PARP inhibitors in colorectal cancer patients with two mutated copies of MRE11. Future trials are being considered using PARP inhibitors to prevent colorectal cancer and other cancers in people with Lynch syndrome whose tumors have this mutation.Microsatellite instability is also seen in prostate cancer and endometrial cancer, suggesting potential for PARP inhibitors to play a role in additional types of cancer as well, Vilar-Sanchez says, adding that more research is needed in these areas.

BOSTON, the United States, April 9 (Xinhua) -- China's clean energy market offers huge business opportunities, experts said at the Harvard China Forum here Saturday.In a panel discussion on clean energy, experts who have been keeping a close eye on China's renewable sectors evaluated its market size, development level and current challenges."No matter it comes to wind, solar or any other type of clean energy, the market capability in China is enormous," Peter Evans, GE Energy's global strategy and planning director said.Evans said he believed China has the need to develop all kinds of energy in order to meet its ever-growing appetite for energy, especially against the background of high oil price, which just surged to nearly 113 U.S. dollars a barrel.He also said China now has the capital needed to develop clean energy but lacked the technology, although that would not be a problem since "every abroad company related to clean energy wants to go to China and to grab something."Gong Li, chairman of Accenture Greater China, said that for a better development of China's renewable sectors, sustainable policy support is needed.On current challenges, Li said one big problem is the lack of network to turn clean energy into electricity. "Renewable energy such as solar and wind is intermediate energy that needs to be transmitted to the power grid, or else it will be garbage energy," Li said.

WASHINGTON, April 3 (Xinhua) -- In the largest study of its kind, researchers from a consortium led by the University of Pennsylvania School of Medicine, the University of Miami, and the Boston University School of Medicine, identified four new genes linked to Alzheimer's disease. The findings appeared Sunday in the current issue of Nature Genetics.Each gene individually adds to the risk of having this common form of dementia later in life. These new genes offer a portal into what causes Alzheimer's disease and is a major advance in the field.The study, conducted by the Alzheimer's Disease Genetics Consortium, reports genetic analysis of more than 11,000 people with Alzheimer's disease and a nearly equal number of elderly people who have no symptoms of dementia. Three other consortia contributed confirming data from additional people, bringing the total number of people analyzed to over 54,000. The consortium also contributed to the identification of a fifth gene reported by other groups of investigators from the United States, the United Kingdom, France, and other European countries.The study is the result of a large collaborative effort with investigators from 44 universities and research institutions in the United States, led by Gerard Schellenberg at University of Pennsylvania."This is the culmination of years of work on Alzheimer's disease by a large number of scientists, yet it is just the beginning in defining how genes influence memory and intellectual function as we age. We are all tremendously excited by our progress so far, but much remains to be done, both in understanding the genetics and in defining how these genes influence the disease process," Schellenberg said.Until recently, only four genes associated with late-onset Alzheimer's have been confirmed, with the gene for apolipoprotein E-e4, APOE-e4, having the largest effect on risk. The Nature Genetics studies add another four -- MS4A, CD2AP, CD33, and EPHA1 -- and contribute to identifying and confirming two other genes, BIN1 and ABCA7, thereby doubling the number of genes known to contribute Alzheimer's disease.

WASHINGTON, Jan. 19 (Xinhua) -- China and the United States have agreed to further boost their bilateral relationship toward a cooperative partnership for the benefit of the whole world, President Hu Jintao said Wednesday.The visiting Chinese leader presented the course forward at a joint press conference at the White House with his U.S. counterpart Barack Obama following their eighth meeting in two years.During the talks, conducted in "a candid, pragmatic and constructive atmosphere," the two sides reached "important agreement on China-U.S. relations and major international and regional issues of shared interests," according to the Chinese president.Chinese President Hu Jintao (2nd L) holds a bilateral meeting with U.S. President Barack Obama (2nd R) at the White House in Washington, the United States, Jan. 19, 2011. "We both agree to further push forward the positive, cooperative and comprehensive China-U.S. relationship," Hu said, adding that both sides also pledged to forge "a China-U.S. cooperative partnership based on mutual respect and mutual benefit" for the benefit of the two countries and beyond.Meanwhile, the two sides "should firmly adhere to the right direction," respecting each other's core interests and handling their relations with a long-term perspective, which will enable both countries to make greater contributions to world peace and development, he said.Citing the growing number of global challenges, the Chinese president stressed that Beijing and Washington "share expanding common interests and shoulder increasing common responsibilities."Accordingly, he added, the two sides have agreed to strengthen exchanges and cooperation in economy, trade, environment, education, science and technology, non-proliferation and counter-terrorism among many other fields.During Hu's ongoing state visit, the two countries signed a number of cooperation agreements. "These will inject fresh momentum into our bilateral cooperation and create a great many job opportunities for our two countries," Hu said.He added that he and Obama also discussed some disagreements in the economic and trade area, with both sides pledging "to continue to appropriately resolve these according to the principle of mutual respect and consultation on an equal footing."Commenting on the relations between the countries's armed forces, Hu said, "We believe expansion of military exchanges and cooperation will be conducive to deepening mutual trust between our two countries."On the situation on the Korean Peninsula, he said that both countries agreed to work together with relevant parties to maintain peace and stability on the peninsula, promote denuclearization of the peninsula and achieve lasting peace and security in Northeast Asia.The Chinese leader reaffirmed China's firm commitment to the path of peaceful development and a win-win strategy of opening up, and appreciated Obama's commitment to a positive and constructive China policy."China is a friend and partner of all countries, and China's development is an opportunity for the world," he said.

NEW YORK, May 27 (Xinhua) -- U.S. stocks expanded gains on Friday ahead of the long Memorial Day weekend as surging commodity prices overcame disappointing economic data.European Central Bank Governing Council member George Provopoulos said that Greece might deal with its debt problem if it sticks to the aid program. That comment, which was considered as bullish by investors, drove the U.S. dollar weaker and led commodity prices surge on Friday.The stock market was driven by higher commodities prices, with thin trading volume ahead of the Memorial Day holiday, despite somewhat disappointing economic data on Friday.The Commerce Department said that both personal income and spending rose 0.4 percent in April, in line with market estimates. However, the rise in spending was the smallest in three months, suggesting the consumption situation was still weak.Meanwhile, pending home sales dropped 11.6 percent in April. The reading was a seven-month low. The market expectation was a drop of 1 percent.Moreover, the Thomson Reuters/University of Michigan Consumer Sentiment index came in above analysts' estimates. Concerns about higher gas prices and inflation had knocked the gauge down in March and April.Despite those disappointing data, analysts still held a bullish view toward the stock market. "Despite our near-term caution, we continue to see the S&P 500 reaching 1400 over the coming year," Alec Young, equity strategist of S&P Equity Research told Xinhua.According to Alex, while recent macro headwinds were raising questions about the sustainability of recent earnings momentum, he still believed that a downside trend of market was fairly limited and that the current weakness is more likely to be a correction, rather than the beginning of a new bear market."In our view, 2011 estimated EPS would have to be excessively optimistic to justify a bear market,"he added.The Dow Jones industrial average added 38.82 points, or 0.31 percent, to 12,441.58. The Standard & Poor's 500 was up 5.41 points, or 0.41 percent, to 1,331.10. The Nasdaq Composite Index rose 13.94 points, or 0.50 percent, to 2,796.86.

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