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Researchers thought they had a way to keep hard-to-treat patients from constantly returning to the hospital and racking up big medical bills. Health workers visited homes, went along to doctor appointments, made sure medicines were available and tackled social problems including homelessness, addiction and mental health issues.Readmissions seemed to drop. The program looked so promising that the federal government and the MacArthur Foundation gave big bucks to expand it beyond Camden, New Jersey, where it started. But a more robust study released Wednesday revealed it was a stunning failure on its main goal: Readmission rates did decline, but by the same amount as for a comparison group of similar patients not in the costly program.“There’s real concern that the response to this would be to just throw up our arms” and say nothing can be done to help these so-called frequent fliers of the medical system, said study leader Amy Finkelstein.Instead, researchers need to seek better solutions and test them as rigorously as new drugs, said Finkelstein, of the Massachusetts Institute of Technology and the National Bureau of Economic Research.Federal grants and research groups at MIT paid for the study, which was 1236

SAN DIEGO, Calif. – What’s usually a marathon for biotech companies is now a full-blown sprint to stop the spread of coronavirus.Kate Broderick, the Senior Vice President of R&D at Inovio Pharmaceuticals in San Diego, remembers the moment she first learned about the mysterious outbreak unfolding thousands of miles away. “Yes, absolutely, distinctly, probably one of those moments you’ll remember forever. I was in my kitchen at home the 31st of December,” said Broderick.She never imagined that two months later it would be the crisis it is today. “Every week I keep thinking it’s going to get better, it’s going to start to tone down a little bit, but in fact, rather than getting better it’s getting worse every week,” said Broderick.Inovio has made headlines before, creating vaccines for Zika, Ebola, and now the coronavirus. After Chinese researchers shared the genetic sequence of COVID-19, Inovio designed a vaccine in just three hours Using its proprietary DNA medicines platform technology. The vaccine was designed to precisely match the DNA sequence of the virus“In an outbreak setting we really don’t have two to three years to wait for a vaccine, so that’s where we come in at Inovio pharmaceuticals, we use DNA medicine technology,” said Broderick.While traditional vaccines use the virus itself, this method puts DNA inside E.coli, which naturally replicates the medicine over and over. The paste is then purified, leaving behind only the DNA medicine, which Inovio hopes to test in humans next month.“Infectious diseases are global and they don’t care about boundaries and borders, everyone is affected from childhood all the way through seniors,” said Phyllis Arthur, who’s been in the infectious disease industry for 20 years.Arthur is Vice President of Infectious Diseases and Diagnostic Policy at BIO, an association made up of about 1,000 companies.“One of the things we’re seeing, from outbreak to outbreak, unfortunately, is we’re getting faster at using platform technologies to build something that can be tried in humans sooner than we were the last time,” said Arthur.She’s following dozens of companies working on vaccines, treatments, and diagnostic tools. If their vaccines work, companies like Inovio will have to figure out how to manufacture them fast.“You may have the best vaccine in the world, but if you can only produce 1,000 doses of it, that’s not really going to help 1.4 billion people in China,” said Broderick. Continued funding will also be critical. Broderick says while their Zika vaccine looked promising in humans, it never ultimately got FDA approval for broad public use.“The problem there was, although great for global health, was that of course cases of the virus really steadily declined, the problem for us there was so did the funding,” said Broderick.She says that way of thinking is shortsighted but does see change on the horizon. “It’s a huge amount of responsibility on everyone’s shoulders, and I think we feel genuinely compelled to do everything in our power, hence why no one complains about two hours of sleep, because this is a point in our careers we can truly, literally, make a difference in saving lives, right now,” said Broderick.After the company begins human trials in the U.S., they’ll continue testing in China and South Korea. They hope to deliver one million doses by the end of the year.If they make it that far, it too would be a day Broderick will never forget. 3462

Senate Minority Leader Chuck Schumer put forth a number of amendments to rules set forth by Majority Leader Mitch McConnell, setting the table for President Donald Trump's removal trial over the next few weeks. All 11 amendments put forth so far on Tuesday have been tabled -- effectively turning them down -- by a party-line vote in all but one vote. Fifty-three Republicans voted to table the amendments, while 47 Democrats voted against tabling in 10 of the 11 votes. The only exception was on Amendment No. 1293 when Republican Susan Collins voted against tabling the motion.McConnell said at the onset of Tuesday's session that the GOP would block votes on all amendments to the rules put forth by him. "If a senator moves to amend the resolution in order to subpoena specific witnesses or documents, I will move to table such motions because the senate will decide those questions later in the trial," McConnell said. But Schumer continued on with a series of amendments. "These amendments are not dilatory," Schumer said. "They only seek one thing, the truth. That means relevant documents, relevant witnesses. That's the only way to get a fair trial and everyone in this body knows it. All 15 that were brought to completion feature witnesses, every single one. The witnesses we request are not Democrats. They're the president's own men."Here is what the Senate has voted on so far today:Amendment No. 1284This amendment would have compelled documents via subpoena from the White House to be used in the Senate trial. Amendment No. 1285This amendment would have compelled documents via subpoena from State Department to be used in the Senate trial. Amendment No. 1286This amendment would have compelled documents via subpoena from the Office of Budget and Management to be used in the Senate trial.Amendment No. 1287This amendment would have issued a subpoena for the testimony for White House Chief of Staff Mick Mulvaney.Amendment No. 1288This amendment would have compelled documents via subpoena from the Department of Defense to be used in the Senate trial.Amendment No. 1289This amendment would have issued a subpoena for the testimony for White House aide Rob Blair and Office of Budget and Management official Michael DuffeyAmendment No. 1290This amendment would have prevented the selective admission of evidence and to provide for appropriate handling of classified and confidential materialsAmendment No. 1291This amendment would have issued a subpoena for the testimony for former National Security Adviser John Bolton.Amendment No. 1292This amendment would have required motions to subpoena witnesses or documents shall be in order after the question period.Amendment No. 1293This amendment would have given additional time for House managers and Trump's legal team to file their responses to motions.Amendment No. 1294This amendment would have required Chief Justice Roberts to rule on motions to subpoena witnesses and documents.The documents requested by Democrats would have included emails, text messages, notes and other communications between White House and other government officials.After nearly 13 hours, the Senate finally voted to approve rules put forth by McConnell to lay out rules and a schedule for the trial. One point of contention was on the schedule for arguments. Originally, McConnell proposed 48 hours of opening arguments, 24 hours by the two respective legal teams, split over four days. After some criticism from Democrats, McConnell altered his proposal to splitting the arguments over six days, giving each team three days each.Another was on how evidence would be accepted by the Senate. 3652

Rescue efforts by authorities and citizens are underway in Texas as Tropical Depression Imelda moves slowly through with flooding and tornadoes.John Adiletta in Galveston got the call that floodwaters left his girlfriend stranded on the road. He set off to rescue her on his own two legs."Well, I did a lot of screaming in my car to get out all the anger before I saw my girlfriend," Adiletta told 410

Stocks are headed lower in afternoon trading on Wall Street after erasing earlier gains, as investors close out a brutal first quarter. The S&P 500 had a loss of more than 20% for the first three months of the year. The surge of coronavirus cases has sent markets tumbling since mid-February, halting what had been a good start to the year. Stocks have clawed back some of those losses with a rally the past week. Massive aid for the economy and markets from the Federal Reserve and Capitol Hill have helped spur some buying. The Dow Jones Industrial Average finished Tuesday down 410 points for the day, ending at 21,917 points. The Dow has lost nearly 8,000 points in the last eight weeks. While many industries saw declines in stock value in Q1 of 2020, the losses were especially pronounced for the travel and oil industries. 846