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The U.S. reached another bleak milestone in the COVID-19 pandemic Wednesday, as Johns Hopkins University reports that 150,000 Americans have now died of the virus.By comparison, about 116,000 Americans died in World War I, according to Encyclopedia Britannica All recorded U.S. deaths have come in the span of just under six months.The U.S. continues to lead the world in deaths linked to the coronavirus. Brazil, with a death toll of about 88,000, is currently the only other country with more than 50,000 deaths.The U.S. currently has more than 4.3 million confirmed cases of the virus, also the most among all world nations.In recent days, the U.S. has seen daily confirmed cases drop slightly, following several consecutive days of near-record case increases. The spread of the virus in hotspots like Arizona, Florida and Texas appears to be slowing.However, Dr. Anthony Fauci — the nation's top expert on infectious diseases — says he is concerned that hotspots could begin moving to Midwest states. Cases are beginning to tick up in places like Missouri, Nebraska and Colorado. 1091

The U.S. will pay more than billion for 100 million doses of a potential Covid-19 vaccine manufactured by Johnson & Johnson.The deal is one of several large agreements between the government and pharmaceutical companies as part of Operation Warp Speed, aimed at creating, testing, manufacturing and distributing a Covid-19 vaccine quickly.The Trump administration’s deal with Johnson & Johnson, announced Wednesday, allows for the purchase of an additional 200 million doses.Johnson & Johnson’s vaccine, developed by subsidiary Janssen Pharmaceutical Companies, has shown positive preclinical results. Testing of their vaccine is currently underway with human trials in the United States and Belgium.The Johnson & Johnson vaccine testing is reportedly behind some of the more advanced-stage potential vaccines, like those from Moderna, Pfizer and AstraZeneca, which have begun phase three human trials.“We greatly appreciate the U.S. government’s confidence in, and support for, our R&D platform and efforts and the scalability of our vaccine technology. We are scaling up production in the U.S. and worldwide to deliver a SARS-CoV-2 vaccine for emergency use,” said Paul Stoffels, M.D., Vice Chairman of the Executive Committee and Chief Scientific Officer, Johnson & Johnson in a statement.The company says they are committed to global access to the vaccine following approvals, and has a goal of supplying 1 billion doses globally through the end of 2021. 1493

The United States has more than double the rate of premature overdose deaths of at least 12 other countries, according to a new?study.The research, published Monday in the Annals of Internal Medicine, says that there were an estimated 63,632 drug overdose deaths in 2016 in the US."The U.S. has the highest death rate due to drug overdoses for both men and women (35 deaths in 100,000 men and 20 deaths in 100,000 women) in 2015, more than double those of any other country in our study," Yingxi Chen, one of the researchers and a postdoctoral fellow at the National Institutes of Health's National Cancer Institute, wrote in an email.Mexico had the lowest rates: 1 death per 100,000 men and 0.2 deaths per 100,000 women.The researchers also found that the United States had the second-highest increase in drug overdose deaths: 4.3% per year in men and 5.3% per year in women, Chen said. Only Estonia had a higher increase.Norway was found to have the biggest decrease in drug overdose mortality for the whole population. Decreases were also found among men and women in Mexico, Spanish men and Danish women.Researchers "looked at the trends and patterns of drug overdose deaths among people age 20 to 64 years in 13 countries of the Organisation for Economic Co-Operation and Development?between 2001-2015," Chen said.These countries were Australia, Chile, Denmark, England, Wales (the data for these two countries was combined), Estonia, Finland, Germany, Mexico, the Netherlands, Norway, Spain and the United States."I think it reinforces what we know about the United States but also points out some of the contrast in terms of the ways other countries have dealt with similar issues," said Caleb Banta-Green, principal research scientist at the University of Washington Alcohol and Drug Abuse Institute, who was not involved in the research.Banta-Green and the researchers both point out that opioids play a part in the high levels of drug overdose deaths in the US.The study describes US opioid deaths as "triple epidemic waves," starting with prescription opioid deaths in the late 1990s, heroin deaths beginning in 2010 and finally deaths due to synthetic opioids, which include fentanyl.Other countries have found solutions to high rates of opioid-related deaths, according to Banta-Green, who cited France, which was not included in the research."When France got rid of the restrictions on prescribers using the medication buprenorphine, their national mortality, opiate overdose mortality rate dropped 79%," he said.Buprenorphine is a drug approved by the US Food and Drug Administration that can be used, alongside behavioral therapies and counseling, to help with the treatment of opioid addiction. It is the "first medication to treat opioid dependency that is permitted to be prescribed or dispensed in physician offices, significantly increasing treatment access," according to the US Substance Abuse and Mental Health Services Administration.Banta-Green believes that creating better access to substance abuse disorder treatments, along with a better national understanding that these are treatable medical conditions, would help reduce the number of overdose-related deaths in the US. This includes giving more people access to medications that could help treat and manage opiate addiction."That's really fundamentally what I think we need to take away from these data finding is that there are solutions, other countries have them, and we are not doing the dramatic things that we need to be doing," he said. 3565

The Russian government denied Monday that it had interfered in the 2016 US election campaign in the Kremlin's first remarks since 13 Russian nationals were indicted Friday on charges of conspiring to defraud the US.Answering a question from CNN on a weekly telephone news conference, the spokesman for Russian President Vladimir Putin, Dmitry Peskov, said the indictments provided "no substantial evidence" of Russian meddling, and that there were "no indications that the Russian state could have been involved.""We didn't see any substantial evidence of someone interfering in the domestic affairs," Peskov added. He said the US indictment "mentions Russian citizens, but we heard the accusations against the Russian state -- that the Russian state, the Kremlin and the Russian government were involved."  820

The Supreme Court has rejected Republicans' last-gasp bid to reverse Pennsylvania’s certification of President-elect Joe Biden’s victory in the electoral battleground. The court without comment Tuesday refused to call into question the certification process in Pennsylvania. Gov. Tom Wolf already has certified Biden’s victory and the state’s 20 electors are to meet on Dec. 14 to cast their votes for Biden. Biden won 306 electoral votes, so even if Pennsylvania’s results had been in doubt, he still would have more than the 270 electoral votes needed to become president.Amid dozens of failed legal challenges since the election, Trump has been meeting with state legislative leaders, including Republican members of the Pennsylvania legislature.A Trump-appointed federal judge was among a three-judge panel that threw out a lawsuit in Pennsylvania. The other two judges were Judge Michael Chagares, a George W. Bush appointee, and Judge D. Brooks Smith, who has been appointed by both GOP and Democratic presidents.“Charges of unfairness are serious. But calling an election unfair does not make it so. Charges require specific allegations and then proof. We have neither here,” 3rd Circuit Judge Stephanos Bibas wrote. Bibas was appointed by Trump to the federal bench in 2017.Last month, a joint statement released by federal and state officials described the presidential election as the “most secure in American history.”The letter was signed by leaders of the Department of Homeland Security’s Cybersecurity and Infrastructure Security Agency, the U.S. Election Assistance Commission and the National Association of State Election Directors, among others. The Cybersecurity and Infrastructure Security Agency was established two years ago as a branch of Homeland Security during the Trump administration.In bold, the authors of the statement wrote, “There is no evidence that any voting system deleted or lost votes, changed votes, or was in any way compromised.” This statement matches those from secretaries of state and boards of election throughout the US.In response to the letter, Trump fired US election security head Chris Krebs. 2154