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The 2019 Nobel Prize for Medicine has been jointly awarded to William Kaelin Jr., Sir Peter Ratcliffe and Gregg Semenza for their pioneering research into how human cells respond to changing oxygen levels.Announcing the prize at the Karolinska Institute in Stockholm on Monday, the Nobel committee said that the trio's discoveries have paved the way for "promising new strategies to fight anaemia, cancer and many other diseases."The 2019 medicine laureates, the committee added, have identified molecular machinery that regulates the activity of genes in response to varying levels of oxygen.The importance of oxygen has long been established, the committee explained, but how cells adapt to changes in its levels remained unknown.Randall Johnson, prize committee member, described the trio's work as a "textbook discovery.""This is something basic biology students will be learning about when they study, at aged 12 or 13, or younger, biology and learn the fundamental ways cells work. This is a basic aspect of how a cell works and, from that standpoint alone, it's a very exciting thing."The winnersNew York-born Kaelin established his own research laboratory at the Dana-Farber Cancer Institute in Boston and became a full professor at Harvard Medical School in 2002.Semenza, also born in New York, became a full-time professor at Johns Hopkins University in 1999 and since 2003 has been the Director of the Vascular Research Program at the Johns Hopkins Institute for Cell Engineering.Ratcliffe, who was born in Lancashire, England, studied medicine at Cambridge University and established an independent research group at Oxford University, becoming a full professor in 1996. 1694

The Centers for Disease Control and Prevention said on Tuesday that it is likely that the spread of coronavirus will reach pandemic levels, as scientists still are trying to solve how to stop the spread of the deadly virus. In the meantime, the CDC has offered some tips it believes will help prevent the spread of the disease. Avoid close contact with people who are sick.Avoid touching your eyes, nose, and mouth.Stay home when you are sick.Cover your cough or sneeze with a tissue, then throw the tissue in the trash.Clean and disinfect frequently touched objects and surfaces using a regular household cleaning spray or wipe.Follow CDC’s recommendations for using a facemask.CDC does not recommend that people who are well wear a facemask to protect themselves from respiratory diseases, including COVID-19.Facemasks should be used by people who show symptoms of COVID-19 to help prevent the spread of the disease to others. The use of facemasks is also crucial for 982

The hit & miss nature of #thunderstorms means it's difficult to forecast exactly where the heaviest rain will be—some parts of #bushfire & #drought affected eastern Australia could see 50–100 mm over the next few days; while others may see very little https://t.co/T7MYuIdxkO pic.twitter.com/zgmiBmqcIG— Bureau of Meteorology, Australia (@BOM_au) January 15, 2020 383

The House Rules Committee met on Tuesday to decide on the process for Wednesday's House session, which will likely result in the impeachment of President Donald Trump. By a 9-4 party line vote, the Rules Committee decided that there will be six hours of debate on the House floor on Wednesday. The six hours will be divided evenly between the two parties. Members of the House will then vote on the two articles of impeachment being offered by House Democrats -- one on obstruction of Congress and another on abuse of power -- individually. Earlier on Tuesday, the Associated Press reported that enough Democrats plus Congress' lone independent have committed to voting for articles of impeachment against Trump. The result would result in Trump becoming the third president in American history to be impeached. The House said that Wednesday's session will get underway at 9 a.m. ET, but it is unclear exactly what time debate on the impeachment will start. 969

The candlelight vigil for two people killed at an off-campus homecoming party near Greenville, Texas, was interrupted by gunfire Sunday, police said.Officers responded to the shooting around 8 p.m. CDT and found a disturbance during the vigil led to shots being fired, according to Dallas police spokeswoman Tamika Dameron.No injuries were reported in the shooting, but several vehicles were damaged, Dameron said.The vigil comes just one day after two people were killed and 14 others were injured during a party Saturday.Police are still searching for the gunman who opened fire at the off-campus party.Efforts to find the shooter are being complicated by witnesses' reticence, Hunt County Sheriff Randy Meeks told reporters."It appalls me that, as many folks that were there, (they) have not been able to give us a better description of this shooter," the sheriff said. "Due to the many different descriptions being provided by those in attendance at that party, we unfortunately do not have any solid suspect information to provide at this time."The party was organized by a group called Good Fellows, some of whose members are students at Texas A&M University-Commerce, though the event was not sanctioned by the school, Meeks said.Of those injured, 12 were shot, he said. Other victims suffered cuts and other injuries from escaping through windows. Five of the victims are being treated at Medical City Healthcare facilities, said hospital spokesperson Melissa Sauvage. They are between 19 and 21 years old.Four of those five are at Medical City Plano, with two in critical condition and two in good condition, Sauvage said. One patient is in critical condition at Medical City Denton.'Complete chaos'Gunshots rang out about 11:45 p.m. (12:45 a.m. ET) Saturday at The Party Venue, an event space located on a sparsely populated stretch of Highway 380. Greenville is a city of 27,000 located 50 miles northeast of Dallas."When the shots were fired it was complete chaos as people fled for safety and deputies attempted to locate the shooter," Meeks said.By 12:10 p.m., deputies were reporting multiple victims.Investigators have yet to identify a suspect or motive, but evidence and witness accounts lead police to believe the gunman walked in the back door of the party, Meeks said. The initial investigation suggests the shooter was not a partygoer but that he likely got to the party before deputies arrived in response to an unrelated complaint, the sheriff said.It also appears, from one witness account, that the shooter targeted his first victim before randomly opening fire with his handgun, the sheriff said.There were bullets on the floor of the venue, but most of them were part of a Halloween costume, he said.Police have interviewed about 20 witnesses, and "none of them (has) given us a good description of the shooter or who they think he may be," Meeks said. There are no surveillance cameras at the venue, either, he said.The FBI and Texas Rangers are assisting in the investigation, he said. A man wearing a Bureau of Alcohol, Tobacco, Firearms and Explosives jacket was also at the scene.There was an off-duty policeman from nearby Farmersville at the event, but the officer was at the front of the venue when the shooting broke out and did not see the gunman, the sheriff said."It was packed," Meeks said. "It gave the opportunity for this shooter to be able to accomplish whatever he wanted to accomplish. When you have this many people in one place, it's an easy target for somebody and then we just had one security guard there. There's no way he could control everything that went on."Number of students unclearThere were about 750 people at the party, about 90% of whom were in their teens or early 20s, said Meeks, imploring the parents of the young people to urge their children to come forward if they know anything.Authorities first responded to complaints of vehicles parked along the highway, Chief Deputy Buddy Oxford said, and the shooting began about 15 minutes after they arrived."Our thoughts and prayers are with the victims, families, and friends of those affected by this morning's shooting in Greenville," Texas A&M University-Commerce said in a statement.Earlier, the school's police department 4261