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The US Food and Drug Administration approved Janssen Pharmaceuticals Inc.'s esketamine on Tuesday for treatment-resistant depression; the drug is the chemical cousin of ketamine, the powerful anesthetic that has been used illegally as the club drug Special K.It will be sold as Spravato. More specifically, it's for patients who have tried at least two other medications without success, and it should be taken with an oral antidepressant."There has been a longstanding need for additional effective treatments for treatment-resistant depression, a serious and life-threatening condition," Dr. Tiffany Farchione, acting director of the Division of Psychiatry Products at the FDA's Center for Drug Evaluation and Research, said in a 745

TUCSON, Ariz. — An Arizona man is facing federal murder charges after investigators say he poured hot water down a 6-year-old's throat, 148

This landlocked state shouldn't have any islands. But the deadly flooding that has deluged parts of Nebraska could get worse before it gets better."This really is the most devastating flooding we've probably ever had in our state's history, from the standpoint of how widespread it is," Gov. Pete Ricketts said Monday.More than 8 million people are under flood warnings in the Midwest and the Mississippi River Valley, said CNN meteorologist Dave Hennen."Eastern Nebraska remains the hardest hit area, with much of the southeast part of the state under flood warnings," he said.The flooding has already killed two people in Nebraska and one man in Iowa. Ricketts said at least one person remains missing in Nebraska.Flood records have been shattered in 17 places, and more rivers will likely break cresting records this week, according to the Nebraska Emergency Management Agency. (A crest is the highest point of a flood wave.)Now the big concern is floodwater draining downstream, further deluging communities that can't take any more water.3 deaths include a farmer trying to rescue othersNebraskan James Wilke, a farmer in Platte County, used his tractor to try to help a person trapped in a vehicle, NEMA spokesman Mike Wight said."With the guidance of emergency responders, James drove his tractor over the Shell Creek bridge on the Monestary Road and the bridge gave out. James and the tractor went down into the flood water below," family friend Jodi L. Hefti wrote on Facebook.Another Nebraska man died after he was overcome by flood waters near a dam in Spencer, Wight said.He said one more person in Nebraska is missing and presumed dead.In Iowa, Aleido Rojas Galan of Nebraska was one of three people rescued from floodwater, Iowa's Fremont County Sheriff's Office said. But Galan, 55, succumbed to his injuries and died at a hospital in Lincoln.This nightmare started with a 'bomb cyclone' The mammoth flooding follows a powerful "bomb cyclone" that slammed the central US last week with hurricane-like winds and blizzard conditions.Melting snow ended up in rivers and streams, causing flooding and cresting days after the precipitation was over.Nebraska's Offutt Air Force Base, just south of Omaha, said about 30 buildings were hit with floodwater."Team Offutt has done an incredible job working together to battle this historic flood as best we can," said Col. Michael Manion, 55th Wing commander. On Sunday, he said the 2449

There's a new first responder on the lookout for anyone who may be experiencing mental health issues.“Most people probably see their pharmacists more than their primary care physicians or certified therapists, so pharmacists are in a really good position to be able to notice these early warning signs or risk factors,” said Chad Cadwell, a Walgreens pharmacist. Walgreens pharmacists just finished the first phase of mental health first aid training. The program was developed by the National Council for Behavioral Health.They're taught to look for risk factors and red flags in patients, everything from anxiety and depression to addiction.Pharmacists can connect those people with the right resources, support groups, or may just lend an empathetic ear.“Really listening to their needs, spending those extra couple of minutes, instead of trying to get the work out, but also spending that time talking and listening to your patients, right now with everything that is going on with the pandemic, everything is so busy,” said Cadwell. This training initiative was actually put into place pre-pandemic.Mental Health America has already seen significant increases in the number of daily screenings for depression and anxiety since the beginning of the year. 1270

Their story gripped the world: determined divers racing against time and water to rescue 12 boys and their soccer coach trapped for more than two weeks in a flooded cave deep inside a northern Thai mountain.The ordeal in late June and early July 2018 had barely ended when filmmakers began their own race to get the nail-biting drama onto cinema screens. The first of those projects will premiere this weekend, when director Tom Waller’s “The Cave” shows at the Busan Film Festival in South Korea.The film was shot over three months earlier this year and has been in post-production since then. The 45-year-old Thai-born, British-raised filmmaker said the epic tale of the Wild Boars football team was a story he simply had to tell.The boys and their coach entered the Tham Luang cave complex after soccer practice and were quickly trapped inside by rising floodwater. Despite a massive search, the boys spent nine nights lost in the cave before they were spotted by an expert diver. It would take another eight days before they were all safe.Waller was visiting his father in Ireland when he saw television news accounts of the drama.“I thought this would be an amazing story to tell on screen,” he said.But putting the parts together after their dramatic rescue proved to be a challenge. Thailand’s government, at the time led by a military junta, became very protective of the story, barring unauthorized access to the Wild Boars or their parents. Waller often feared his production might be shut down.His good fortune was that the events at the Tham Luang cave in Chiang Rai province had multiple angles and interesting characters. Especially compelling were the stories of the rescuers, particularly the expert divers who rallied from around the world. He decided to make a film “about the volunteer spirit of the rescue.”Other people proposed telling the story from the point of view of the boys, and Netflix nailed down those rights in a deal brokered by the Thai government.“I took the view that this was going to be a story about the people we didn’t know about, about the cave divers who came all the way from across the planet,” Waller said. “They literally dropped everything to go and help, and I just felt that that was more of an exciting story to tell, to find out how these boys were brought out and what they did to get them out.”Waller even had more than a dozen key rescue personnel play themselves.Waller said they were natural actors, blending in almost seamlessly with the professionals around them, and helped by the accuracy of the settings and the production’s close attention to detail.“What you are really doing is asking them to remember what they did and to show us what they were doing and what they were feeling like at the time,” he said. “That was really very emotional for some of them because it was absolutely real.”Waller said his film is likely to have a visceral effect on some viewers, evoking a measure of claustrophobia.“It’s a sort of immersive experience with the sound of the environment, you know, the fact that is very dark and murky, that the water is not clear,” he said.“In Hollywood films, when they do underwater scenes, everything is crystal clear. But in this film it’s murky and I think that’s the big difference. This film lends itself to being more of a realistic portrayal of what happened.”Some scenes were filmed on location at the entrance to the actual Tham Luang cave, but most of the action was shot elsewhere, Waller said.“We filmed in real water caves that were flooded, all year-round,” he said. “It is very authentic in terms of real caves, real flooded tunnels, real divers and real creepy-crawlies in there. So it was no mean feat trying to get a crew to go and film in these caves.”“The Cave” goes on general release in Thailand on Nov. 28. 3824