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New research suggests that antibodies the immune system makes to fight the new coronavirus may only last a few months in people with mild illness, but that doesn’t mean protection also is gone or that it won’t be possible to develop an effective vaccine.“Infection with this coronavirus does not necessarily generate lifetime immunity,” but antibodies are only part of the story, said Dr. Buddy Creech, an infectious disease specialist at Vanderbilt University. He had no role in the work, published Tuesday in the New England Journal of Medicine.The immune system remembers how to make fresh antibodies if needed and other parts of it also can mount an attack, he said.Antibodies are proteins that white blood cells called B cells make to bind to the virus and help eliminate it. The earliest ones are fairly crude but as infection goes on, the immune system becomes trained to focus its attack and to make more precise antibodies.Dr. Otto Yang and others at the University of California, Los Angeles, measured these more precise antibodies in 30 patients diagnosed with COVID-19 and four housemates presumed to have the disease. Their average age was 43 and most had mild symptoms.Researchers found that the antibodies had a half-life of 73 days, which means that half of them would be gone after that much time. It dovetails with a previous report from China also suggesting antibodies quickly fade.The results “call for caution regarding antibody-based ‘immunity passports,’ herd immunity, and perhaps vaccine durability,” the California authors write.That’s true, Creech said, but other parts of the immune system also help confer protection. Besides churning out antibodies, B cells develop a memory so they know how to do that again if needed.“They would get called into action very quickly when there’s a new exposure to the virus. It’s as if they lie dormant, just waiting,” he said.Other white blood cells called T cells also are better able to attack the virus the next time they see it, Creech said.Although circulating antibodies may not last long, what we need to know is if and how people remake antibodies if exposed to the coronavirus again and if they protect against another infection, Alison Criss, an immunologist at the University of Virginia, wrote in an email. “We also need to know if there is a protective T cell response” that reappears.Vaccines, which provoke the immune system to make antibodies, might give longer-lasting protection than natural infection because they use purified versions of what stimulates that response, she noted.Creech agreed.“This shouldn’t dissuade us from pursuing a vaccine,” he said. “Antibodies are only a part of the story.”___Marilynn Marchione can be followed on Twitter at http://twitter.com/MMarchioneAP___The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. 2967
NEW YORK -- A bodega clerk who was attacked by a customer in New York City is concerned mask laws will get someone killed, he said Sunday.Javier Franco and Aneuri Castillo were in a Morrisania bodega several weeks ago when they were attacked. Franco was stacking the shelves when he asked a customer to put on a mask. The customer punched him in the face.“The mask law is going to get someone killed," Franco said. "We are doing our best trying to obey the law so we don’t lose our liquor license, but it seems we could lose our life instead."Castillo was smacked in a mask confrontation with a customer."This was shocking to me," he said. "I tried to do what the governor asked us. I told him it was the law. I’m scared! Maybe he’ll come back and shoot me. It’s so hard coming to work not knowing how the day will go. I have a family and they need me, I don’t want to die in the bodega."United Bodegas of America spokesman Fernando Mateo said both incidents happened within minutes of one another. He said they're meeting with NYPD Commissioner Dermot Shea soon to address their concerns.“The mayor and the governor have a responsibility to keep us all safe," he said. "We invested in NYC and they must ensure our public safety."This story was originally published by Aliza Chasan at WPIX. 1298

NEW YORK (AP) — A federal judge has approved a request from a group of WeChat users to delay looming U.S. government restrictions that could effectively make the popular app nearly impossible to use.In a ruling dated Saturday, Magistrate Judge Laurel Beeler in California said the government’s actions would affect users’ First Amendment rights as an effective ban on the app removes their platform for communication.WeChat is a messaging-focused app popular with many Chinese-speaking Americans that serves as a lifeline to friends, family, customers and business contacts in China.It’s owned by Chinese tech giant Tencent.As of Monday morning, WeChat was still available for download through Apple and Android app stores. 731
Next week, folks who are traveling can expect really crowded airport lines.There will be a 7 percent increase in those flying to their Thanksgiving celebrations, the Transportation Security Administration announced.The Thanksgiving rush at airports will last 10 days beginning Nov. 16 and stretching to Nov. 26.The Sunday after Thanksgiving is likely going to be the heaviest travel day of 2018, officials said — it is expected to break into TSA's top 10 busiest days ever. 481
Nominations for the 61st Grammy Awards were announced Friday and one of the nominees was brought to tears live on television.Singer Janelle Monáe -- along with Alessia Cara and Shawn Mendes -- announced some the nominees on "CBS This Morning." Monáe became emotional when her "Dirty Computer" was announced for album of the year.She said she was moved because the project is "about community," especially the LGBT community of which she is a part."I hope they feel seen," Monáe said. "I hope they feel loved and I hope they feel celebrated."Rap artists Kendrick Lamar and Drake received the most nominations with eight and seven, respectively. Singer/songwriter Brandi Carlile received six nominations.Fans of H.E.R., the singer/musician who wears sunglasses and guards her privacy to keep the focus on her music, had plenty to celebrate with her multiple nominations.She scored nods for best R&B album, album of the year and best new artist.Female artists dominated top categories this year. Seemingly in an effort to address a historic lack of diversity among its previous nominees, the Grammys expanded the major categories of album of the year, record of the year, song of the year and best new artist from five nominees to eight.There was controversy early on when rapper Cardi B and rapper/singer Post Malone were deemed ineligible for the best new artist category.But the pair did well anyway.Malone's "Beerbongs & Bentleys" is up album of the year, as is Cardi B's "Invasion of Privacy."Her hit "I Like It" is also up for record of the year.Here's a list of some of the Grammy nominees. The complete list of more than 80 categories can be found on Grammys.com. 1690
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