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LONDON (AP) — AstraZeneca and Oxford University have acknowledged a manufacturing error that is raising questions about preliminary results of their COVID-19 vaccine.A statement Wednesday describing the error came days after the company and the university described the shots as “highly effective” and made no mention of why some participants didn’t receive as much vaccine as expected.In a surprise, the group of volunteers that got half a dose in the first of their two shots seemed to be better protected than the volunteers who got full doses. The low-dose group was smaller and younger, however, which could have skewed the results, experts say.In a statement obtained by CNN, Oxford elaborated further, saying that a “difference in the manufacturing process” had led to the error.The university said that it discussed the problem with regulators, agreed to complete the late stage trial with two groups, and the problem has since been corrected. 959

LOS ANGELES (CNS) - Gov. Gavin Newsom said Monday he understands the frustrations of people who have been protesting police brutality across the state, but he lashed out at those who are taking advantage of the unrest to engage in looting.Newsom also declined to directly respond to comments made by President Donald Trump in a conference call with the nation's governors Monday morning, in which the president called many of their responses to protests "weak.""I have a choice. We all have a choice," Newsom said. "I can be part of the daily back and forth in the news cycle, and to continue to perpetuate the problems that persist in this country. I can choose to go back and forth and just be another voice in that cause. Or I can choose to focus a message that I think is so much more powerful that I hope has more resonance for people watching, and that is I care more about them than some of the noise I heard on a morning phone call."RELATED: Looters smash windows, rob stores in downtown San DiegoNewsom expressed solidarity with protesters and their call for change in a system that has failed communities for generations."The black community is not responsible for what's happening in this country right now. We are," he said. "Our institutions are responsible. We are accountable to this moment."RELATED: La Mesa community comes together to clean up downtown after Saturday riotsBut he said he had no patience for those who are taking advantage of the protests to engage in lawlessness."When you're out there to exploit conditions, not advance the cause of justice -- that is not serving the greater good," he said. "And we need to also call that out. The looting, the violence, the threats against fellow human beings -- that has no place in this state and in this nation. We as a society need to call that out."RELATED: San Diego County law enforcement denounce George Floyd's deathHe said another 1,100 members of the National Guard have been called up to assist cities across the state cope with the protests and violence, bringing the total to about 4,500. But he said the state and nation as a whole need to do more than just respond to the protests on the streets."We are committed and resolved to bringing peace back to the streets, not only in the state but supporting efforts all across this nation," he said. "But it's not just a situational moment. we have to focus on the medium and long-term and we have to prove our commitment and our resolve in that space." 2492

LOS ANGELES (AP) — Two young sisters missing from their Northern California home since Friday afternoon were found alive Sunday following a massive search that included helicopters and tracking dogs.Leia Carrico, 8, and Caroline Carrico, 5, were found "safe and sound" on Sunday morning by a fire captain and firefighter who had followed the girls' boot tracks, Humboldt County Sheriff William Honsal said."This is an absolute miracle," he said.Though the girls were dehydrated and cold, they were uninjured and "in good spirits," Honsal said.He said the girls were trained in outdoor survival through their local 4-H club and that authorities believed that helped them. They also were wearing boots and had eaten granola bars at some point while they were missing, he said."To have a positive outcome like this is just absolutely amazing," Honsal said.Using helicopters and tracking dogs, dozens of police and rescue personnel combed a vast and rugged rural area in the frantic search for the sisters.The girls had last been seen around 2:30 p.m. Friday outside their home in Benbow, a small community about 200 miles (320 kilometers) northwest of Sacramento.The searchers included National Guard members from Fresno and the U.S. Coast Guard, which provided one of its helicopters on top of a Black Hawk helicopter also being used.Rescuers were hopeful about finding the girls Saturday after they came across prints from the girls' rubber boots and wrappers from the granola bars, Lt. Mike Fridley said."The wrappers showed us a direction from where they started to where the wrappers ended up at," Fridley said.Fridley said he was the one who got to call the girls' mother and tell them her daughters were alive."She melted on the phone," he said.Honsal described the search area as vast, rugged and rural and the conditions as cold and sporadically rainy. 1866

LOS ANGELES (CNS) - Travelers coming through Los Angeles International and Van Nuys airports and Union Station beginning Wednesday will be required to sign a form acknowledging California's recommended 14-day self-quarantine in response to rising coronavirus rates.The form will be available at travel.lacity.org, Mayor Eric Garcetti said during a coronavirus briefing Monday.Garcetti urged people to not travel over the Thanksgiving holiday, not even to go across town because of how widespread COVID-19 cases have been and that it's too dangerous at this time.Garcetti said he is confident the Los Angeles County Board of Supervisors, which is slated at Tuesday's meeting to discuss coronavirus- related restrictions and closures, will make the right decisions."I know this is not popular with everybody, but if we don't take these actions now, when will we?" Garcetti said. "I know there may be some push and pull ... but I think the policies that (the county Department of Public Health) adopted are clear."Garcetti said when local government has hesitated implementing COVID- 19 restrictions, businesses have had to remain closed for longer because of the spread of the virus. But he also said he knows businesses are struggling."I've spoken with our City Council President (Nury Martinez), I've spoken with our county supervisors, and know that if those orders do come down, where we have to stop outdoor dining or limit the hours of other businesses, we will take the funds that we have in business assistance and surge them into those industries to get us through this period to keep those businesses alive to protect those jobs and to make sure that they can stand up again," Garcetti said.Garcetti said Los Angeles County could be out of hospital beds for coronavirus patients by Christmastime, if the rate of COVID-19 positive cases continues on its current trend.Field hospitals may have to be established if that happens, Garcetti said. However, Garcetti said he doesn't think the U.S. Navy's hospital ship Mercy will need to return. It docked at the Port of Los Angeles for use in non- coronavirus cases over the spring and summer as safeguard against a lack of hospital beds that did not materialize.Garcetti said he had a discussion Monday with President-elect Joe Biden and Vice President-elect Kamala Harris regarding the state of Los Angeles and its fight against COVID-19, telling them the virus will spread further if people don't follow health protocols."It doesn't matter what you've done last week or last month," Garcetti said he told Biden and Harris. "COVID doesn't care what we've done before today."COVID only cares how we are acting right now, and the moment we stop acting to protect lives, the moment we ignore the numbers or hope that somehow they will just go away is the moment lives are lost."COVID-19 testing sites in Los Angeles will be closed Thursday and Friday for Thanksgiving, but will reopen Saturday, Garcetti said. 2968

Local police have noted a disturbing increase in the amount of animals found to have been shot and dumped left to die.Previously, Scripps station WTVF in Nashville reported a?spike in the number of canine thefts in Middle Tennessee that was possibly connected to a local theft ring. Now, rather than just disappearing, the dogs are being killed.One beagle did survive. It was shot in the head and found dumped in a bag. Thankfully, veterinarians in nearby Winchester were able to save the dog.But others were not so lucky. Concerned citizens have sent in photos of dogs found shot and then dumped by the side of the road in a half-dozen middle Tennessee counties."It think it's horrible and we need to figure out why it's happening and who is doing it," said veterinarian Allison Fields at the Hermitage Animal Clinic in Davidson County.The dogs were shot with guns in more rural counties. Now, many wonder if some of them were among the many stolen in recent months."This is a big problem of people taking dogs from people coming into the yard and just snatching them out of yards and just taking them," said Earl Stouzenberger, who lost his dog Leia, earlier this year.Police have been checking for chips in the dead dogs hoping to locate owners."Absolutely, I'm sure they have. Animal Control or police stations will have a scanner," Fields said. But identifying the dogs doesn't solve the riddle of why they were shot and often dumped in public places. To date, no one has been charged or arrested in connection with the dog thefts or killings.Catching those responsible is a long shot. The best and really only line of defense for local pet owners is to keep an eye on them.Investigators say the shootings are difficult to explain. They are asking anyone who witnesses a shooting or has any information to contact a local police station or sheriff's office. 1920