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Scientists are working to eliminate a type of heart disease in dogs using gene therapy. They're zoning in on a heart condition called mitral valve disease that’s common in 6% of dogs. Scientists are using Cavalier King Charles spaniels for the research. They tend to develop it at a younger age. Scientists at Tufts University have already tested gene therapy in mice. A virus is injected into them to deliver DNA to cells which causes them to create a protein. What it essentially does is stops the heart valve from getting thicker, stopping the valve from leaking. Researchers are now moving on to testing this in dogs. But they think the treatment could go beyond just canines. “Many of the dog diseases are naturally occurring and really great models for human disease,” says Dr. Vicky Yang, a veterinary cardiologist and research assistant professor at Cummings School of Veterinary Medicine at Tufts University. “And I can see this, if it becomes successful in dogs, potentially going into thinking about treatment for humans for mitral valve disease.”The biotech company behind the treatment agrees. It says it could also expand beyond heart problems. “I think a larger question, though, is if we are able to prove this thesis of treating aging, making the animal generally healthier, could also treat heart failure, what other diseases could we treat in dogs?” says Daniel Oliver, the CEO of Rejuvenate Bio. “And could we progress this treatment onto past dogs and other animals and possibly humans?” The gene therapy would only be used for dogs just starting to experience heart problems.Researchers still need to make sure the gene therapy is safe for all breeds before they make it available to the public. 1730

A gender discrimination lawsuit filed by members of the US women's soccer team against the US Soccer Federation has been scheduled for trial starting May 5, a spokeswoman for the players said."We are pleased with the expeditious schedule that has been set by the court and we are eager to move forward this case," Molly Levinson, spokeswoman for the players, said Tuesday. "We very much look forward to the trial in May 2020 when the players will have their day in court."We have every confidence that these world champion athletes will get what they legally deserve -- nothing less than equal pay and working conditions."US Soccer declined to comment.The US Women's National Team's lawsuit was filed in March in US District Court in California, with 28 members of the team listed as plaintiffs.The suit alleges US Soccer's payment practices amount to federal discrimination by paying women less than men "for substantially equal work and by denying them at least equal playing, training, and travel conditions; equal promotion of their games; equal support and development for their games; and other terms and conditions of employment equal to the MNT."Mediation talks between US Soccer and the US women's soccer team broke down, Levinson said last week.The players had previously requested a November 2020 trial date, while US Soccer asked that the trial begin in December 2020.The argumentIn one hypothetical case cited in the lawsuit, if the women's and men's teams both won 20 straight games in a season, the women would make 38% what the men do.Last month, US Soccer said the reigning Women's World Cup champions earned more than the US Men's National Team, with US Soccer president Carlos Cordeiro releasing an open letter on Twitter saying that from 2010 through 2018, the federation paid .1 million in salary and game bonuses to the women, compared with .4 million for the men.Those figures did not include benefits, such as health care, that the women receive. Included in the federation's numbers is that US Soccer pays USWNT contracted players a salary to play in the National Women's Soccer League, while the men are paid by their individual teams.The women's and men's compensation structures are different, as those each were collectively bargained.The figures were described as misleading and "utterly false" by Levinson in a July written statement.America's women have been far more successful than their male counterparts, winning four World Cups -- the most recent last month in France -- and four Olympic gold medals.The USMNT said its players, too, "were not impressed" by Cordeiro's letter. "The women's national team players deserve equal pay and are right to pursue a legal remedy from the courts or Congress," the men's team said.Sponsors have added to the pressure to resolve the equal pay fight, with deodorant brand Secret saying in July that it planned to contribute 9,000 to the USWNT players' association.Nike, US Soccer's biggest partner, has also said it's a strong advocate for pay equity. "Regarding gender equality, Nike has been an advocate for women and girls in the US and around the world," a spokesperson said.Minutes after the USWNT's World Cup win on July 7, Nike ran a 60-second ad celebrating the team's victory, centering on the concept that the USWNT's win is about more than winning a soccer title. However, Nike has been criticized for reducing athletes' pay during their pregnancies, a practice it said in May it would discontinue.It emerged this month that US Soccer had enlisted two lobbying firms, FBB Federal Relations and Vann Ness Feldman, to push back against claims of pay disparity after two Democratic senators introduced legislation that would require equal pay for men's and women's national teams.The move had left the team "stunned and disappointed," Levinson told CNN. 3854

A game was stolen...And so were tacos. Stop into Taco Bell on June 18 from 2-6PM to score your free Doritos? Locos Tacos. Or better yet, any time online or on the app. 180

A close associate of President Donald Trump's personal lawyer, Rudy Giuliani, has provided a trove of text messages and photos to the House committee leading the impeachment inquiry. Joseph Bondy, the lawyer for Lev Parnas, tweeted Monday that they had “worked through the night” to provide data from two of his client's smartphones to the House Intelligence Committee. The Democrat-led committee subpoenaed Parnas for documents on Oct. 10, the day after news broke that he and business partner Igor Fruman had been arrested by federal authorities while trying to board a one-way flight to Europe.To read the documents, click 638

Scientists are working to eliminate a type of heart disease in dogs using gene therapy. They're zoning in on a heart condition called mitral valve disease that’s common in 6% of dogs. Scientists are using Cavalier King Charles spaniels for the research. They tend to develop it at a younger age. Scientists at Tufts University have already tested gene therapy in mice. A virus is injected into them to deliver DNA to cells which causes them to create a protein. What it essentially does is stops the heart valve from getting thicker, stopping the valve from leaking. Researchers are now moving on to testing this in dogs. But they think the treatment could go beyond just canines. “Many of the dog diseases are naturally occurring and really great models for human disease,” says Dr. Vicky Yang, a veterinary cardiologist and research assistant professor at Cummings School of Veterinary Medicine at Tufts University. “And I can see this, if it becomes successful in dogs, potentially going into thinking about treatment for humans for mitral valve disease.”The biotech company behind the treatment agrees. It says it could also expand beyond heart problems. “I think a larger question, though, is if we are able to prove this thesis of treating aging, making the animal generally healthier, could also treat heart failure, what other diseases could we treat in dogs?” says Daniel Oliver, the CEO of Rejuvenate Bio. “And could we progress this treatment onto past dogs and other animals and possibly humans?” The gene therapy would only be used for dogs just starting to experience heart problems.Researchers still need to make sure the gene therapy is safe for all breeds before they make it available to the public. 1730