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SAN DIEGO (KGTV) — Researchers at the University of California, San Francisco are working on a spray designed to block the novel coronavirus from hijacking cells in the body, like a biological mask or internal personal protective equipment.They’re doing it by borrowing a defense mechanism from an unlikely source: llamas.The team, led by UCSF graduate student Michael Schoof, engineered a synthetic molecule based on one found in a llama’s immune system that acts like an antibody but is one-tenth the size.Human antibody treatments, known as convalescent plasma, require a transfusion in a hospital setting. But this smaller molecule, called a nanobody, can be easily self-administered via an inhaler or nasal spray and rapidly manufactured using yeast, Schoof said.The scientists named their product AeroNabs. They say it could be an inexpensive intervention for treating and preventing COVID-19 while the world waits for a vaccine.“We don't know how effective vaccines will be. We don't know how long it will take to rapidly deploy them, so we envision this product as hopefully a bridge until there is widespread, effective vaccination,” Schoof said.Once a vaccine is available, AeroNabs could offer protection for individuals who are unable to be inoculated for health reasons, he said, or an early treatment option.The team is in talks with commercial partners and hopes to begin clinical trials soon.In the 1980s, Belgian scientists discovered that about half of the antibodies in camels, llamas and alpacas are shaped differently than the antibodies found in other mammals, including humans. Researchers later learned they could use a fragment of these oddly shaped camelid antibodies to bind to antigens.Those fragments are called nanobodies.Currently, there is only one FDA-approved drug that uses nanobodies. Caplacizumab was approved last year to treat a rare blood disorder.The team at UCSF sifted through billions of nanobodies to find one that binded best to the spike proteins on the coronavirus, then engineered it to stick even better.The coronavirus uses its spikes to enter cells and replicate; the spikes are essentially the pathogen’s key into the body. By coating the spikes with nanobodies or antibodies, the viral key no longer fits into the body’s receptors and the virus can’t get in.“This works in the lab. It needs to be translated into the clinic,” said Schoof.The team at UCSF still needs to figure out the best delivery method, whether it is a nebulizer, an inhaler or a nasal spray. 2524

SAN DIEGO (KGTV) — San Diego health officials are worried about a recent uptick in out-of-towners testing positive for coronavirus locally ahead of the holiday weekend.In San Diego, health officials have seen increases in positive COVID-19 cases diagnosed locally in people who live in nearby counties or states. Throughout the pandemic, there have been 16 Arizona residents have tested positive while in the region, seven of those were in the last week. So far, 330 Imperial County residents have tested positive while in San Diego and 61 of those were in the last week, as cases grow in that county.RELATED: San Diego County to close bars that don't serve food to slow COVID-19 spread"We have looked specifically at nearby county residents. Certainly, the number of individuals who live in Imperial County who are diagnosed in San Diego have increased in the last number of weeks," said Dr. Eric McDonald, director of the county’s epidemiology and immunization department. "The number of cases who have Arizona as their primary residence have also increased in the last number of days."With Monday's decision to close bars that don't serve food ahead of the July 4 weekend, the hope is the move will deter out-of-county residents from coming to San Diego."If you go back to some of the restrictions that were announced today, so that we are more consistent with our neighboring counties in terms of bar closures, it somewhat addresses that," McDonald said. "Certainly, if all the surrounding areas had more restrictions and we were perceived as a place where individuals could have more freedom to do certain types of social interactions, that could be a draw."RELATED: Gov. Newsom shuts down bars in Los Angeles, six other counties amid surge in COVID-19 casesSan Diego's beaches are scheduled to remain open as of Monday. Nearby Los Angeles County officials announced they will close their beaches for the weekend."We're going to reach out to the cities and assess their level of comfort in being able to enforce the physical distancing requirements at the beaches," Supervisor Nathan Fletcher said. "We have, to date, not seen significant numbers of outbreaks or case trends from outdoor settings. So there is more concern about indoor than outdoor. But it is something we're certainly going to reach out to the cities to ascertain." 2347

SAN DIEGO (KGTV) — San Diego County reported a record new 1,802 coronavirus cases on Friday, bringing the region's total to 78,159 cases thus far.The new cases resulted in an 8% positive rate out of 21,671 reported tests for the county's daily tally. No new deaths were reported on Friday, as the death toll sits at 996.The new case totals come as public and federal health officials urge the public to keep gatherings limited and small this Thanksgiving and not to travel.Hospitalizations in the county remained at 580 on Friday, while ICU cases rose slightly from 166 to 173 — both of which have nearly doubled since a month earlier, according to the county's data.There were 82 community outbreaks in San Diego County as of Friday. A community outbreak is defined as three or more COVID-19 cases in a setting and in people of different households over the past 14 days. 880

SAN DIEGO (KGTV) -- San Diego is one of the least affordable cities for renters, according to a new report by WalletHub. The new report looked at 182 cities around the United States and ranked them based on rental affordability and quality of life. According to the report, San Diego is the 177th least affordable place to rent out of the 182 cities. Only five cities in the U.S., most of them in California, are less affordable than San Diego. Those cities are Santa Ana, Santa Rosa, Bridgeport, Connecticut, Oceanside, California and Hialeah, Florida. However, when it comes to quality of life, San Diego placed 2nd, only topped by Scottsdale, Arizona. Overall, America’s Finest City placed 44th on the list. Although San Diego is expensive, it may be more affordable to buy a home than rent is some areas. A new report found that it is actually more affordable to buy than it is to rent in Chula Vista. A new program also vows to help teachers buy homes. 967

SAN DIEGO (KGTV) — San Diego is packed with art this weekend.Whether you plan to enjoy the Oceanside Jazz Festival or Asian Film Festival spring showcase, you have plenty of options around the county.The San Diego Museum of Art will bring works of art into a new context, with creations of art using flowers in Art Alive, and the San Diego Botanic Garden will host works from some of the region's best artists throughout the garden.RELATED: Things to do for free in San Diego CountyFor an experience that will surely broaden you pallet, check out Taste of Hillcrest or the Fallbrook Avocado Festival for delicious creations by San Diego's culinary minds.Here's a look at this weekend in town:THURSDAY13th Annual Oceanside Jazz FestivalWhere: MiraCosta College, Oceanside; Cost: Free - (Thursday - Saturday) International recognized jazz singers and students with the MiraCosta College jazz program will perform as part of the Oceanside Jazz Festival, with clinics also being held by student singers and visiting choirs.9th annual Asian Film Festival Spring ShowcaseWhere: UltraStar Mission Valley; Cost: - (Thursday - Sunday) Watch the best of Asian and Asian American cinema during the San Diego Asian Film Festival's spring showcase of films. The showcase highlights South Asian and Southeast Asian stories, as well as a special collection of Filipino films and works shedding light on LGBTQ Asian stories.FRIDAYArt AliveWhere: San Diego Museum of Art; Cost: (Friday - Sunday) Nearly 100 floral designers' interpretations of works of art will be showcased throughout San Diego's Museum of Art during Art Alive, combining a multitude of colors and scents across the museum's galleries.Spring Critter Camp Where: Helen Woodward Animal Center; Cost: - (Thursday - Friday) Kids can get an up-close and personal looks at animals with the Helen Woodward Animal Center during Spring Critter Camp. Thursday, campers can expect to interact with a miniature horse, chicken, and ball python with learning about animals families, and Friday, kids can learn about animals and the Earth with a leopard gecko, miniature donkey, and Madagascar hissing cockroach.Cirque Du Soleil: Volta Where: Del Mar Fairgrounds; Cost: starting at (Thursday - Sunday) Experience the magic of Cirque Du Soleil under the bog top at Del Mar this weekend, as the energetic circus brings amazing feats using dance, high-flying maneuvers, and even BMX choreography.SATURDAY18th annual Taste of HillcrestWhere: Hillcrest; Cost: More than 35 of some of Hillcrest's best restaurants will offer a taste of their menu's during Taste of Hillcrest, with special samples being offered at eateries and bars spanning the culinary landscape on your very own walking tour of the town. Spring EGGstravaganzaWhere: Birch Aquarium at Scripps; Cost: Free with admission(Saturday - Sunday) Celebrate the Easter season at Birch Aquarium, where the East Bunny will don scuba gear to fee the fishes, as guests can explore more about animal eggs, create a shark egg, and participate in an "underwater" egg hunt.Selena-dedicated Del Barrio MarketWhere: Barrio Logan; Cost: FreeHead to Barrio Logan to pay tribute to Selena, the beloved singer whose life was cut short, but who still inspires countless of people. The Del Barrio Market will be dedicated to Selena and feature local vendors, crafters, artisans. Some vendors will offer merchandise inspired by the singer.San Diego Botanic Garden ArtFestWhere: San Diego Botanic Garden; Cost: Free with paid admission(Saturday - Sunday) More than 30 of the region's finest artists will display their works throughout the scenic space of the San Diego Botanic Garden this weekend. From sculptors to painters to potters, ArtFest will feature art on display and for sale as well as live music throughout the garden.SUNDAY33rd annual Fallbrook Avocado FestivalWhere: East Alvarado St. at South Main Ave. in Fallbrook; Cost: FreeYou won't be charged extra to enjoy Fallbrook's Avocado Festival, featuring live music, a wine garden, a kid's zone, and avocado trees available for sale to plant at home. Come out and sample avocados, enjoy some of the crazy avocado-fueled creations by cooks, or find a piece of avocado gear to take home.Port of San Diego's Day at the DocksWhere: Sportfishing Landing; Cost: FreeEnjoy free fishing seminars, kids fishing activities, knot tying and carting contests, discounted boat rides around the bay, and more during the port's Day at the Docks. The event will also feature sport fishing boats to check out and entertainment throughout the day.6th annual Mariachi FestivalWhere: California Center for the Performing Arts, Escondido; Cost: - 0Enjoy incredible mariachi performances by the The First Ladies of Mariachi, Mariachi Sol de México de José Hernández, and Ballet Folklórico Tierra Caliente as they take the stage as part of this year's Mariachi Festival. VIP ticket holders can enjoy a special “tacos and tequila” reception. Proceeds benefit college scholarship, literacy programs, and leadership opportunities through the center.Spring EggtravaganzaWhere: Santee Lakes; Cost: tickets for rides and activitiesHead out for family fun at Santee Lakes, where kids can take part in egg hunting throughout the day, jump into carnival games and pony rides, crafts, and more ahead of the Easter holiday. 5365