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BEIJING, Aug. 22 (Xinhuanet) -- Researchers have discovered how a human egg captures an incoming sperm for fertilization, paving the way to help couples suffering from infertility, according to media reports on Monday.An international team of researchers found that a sugar chain known as the sialyl-lewis-x sequence (SLeX) makes the outer coat of the egg “sticky,” which has proven to be helpful in binding the egg and the sperm.As a result, this observation has filled in a huge gap in the understanding of fertility and provides hope for ultimately helping couples who currently cannot conceive.Scientists and doctors know that a sperm identifies an egg when proteins on the head of the sperm match and bind to a series of specific sugars in the egg’s outer coating. With a successful match of proteins, the outside surfaces of the sperm and egg then bind together before merging, which is then followed by delivery of sperm’s DNA into egg.To identify this molecules, the researchers used ultra-sensitive mass-spectrometric imaging technology to observe and identify which molecules are most likely to be key in the binding process.They experimented with a range of synthesised sugars in the laboratory and found that it is SLeX that specifically binds sperm to an egg.According to the World Health Organisation, infertility affects about 15 percent of reproductive-aged couples around the world and almost one in every seven couples in Britain has problems conceiving a child for various reasons.
CANBERRA, Sept. 24 (Xinhua) -- Australian scientists on Saturday said a satellite due to re-enter Earth poses a negligible threat to life and property on Earth.U.S. National Aeronautics and Space Administration's Upper Atmosphere Research Satellite (UARS), which weighs more than five tons, is expected to re-enter the Earth's atmosphere at 1058 (AEST) on Saturday. The U.S.-based Center for Orbital and Re-entry Debris Studies estimates that re-entry could occur up to seven hours before or after this time.According to Nonathan Nally, a former editor of two space magazines and currently editor of the Australian Space News website, the satellite poses a negligible threat to life and property on Earth."Most of the satellite will burn up on re-entry, with perhaps as many as 26 stronger or harder small pieces surviving to reach the surface," Nally said in a statement."But with the majority of the Earth comprising oceans or uninhabited (or very sparsely populated) remote regions, the chances are overwhelming that any pieces of UARS that survive re- entry will fall harmlessly and never be seen again."Since the spacecraft is no longer powered, U.S. National Aeronautics and Space Administration has no control over where it comes down, but Nally said there is a small chance that debris from the satellite could land in Australia.Debris from SkyLab, another satellite which plunged to Earth, was scattered over parts of Western Australia in 1979. Skylab weighed about 77 tonnes, many times more than the UARS.?Dr Alice Gorman, a lecturer in the Department of Archaeology, specializing in space archaeology, at Flinders University in South Australia, said the UARS satellite re-entry is very reminiscent of Skylab in 1979."There is the same exaggeration of the hazard through the media, public anxiety as the advance warning allows for speculation, and a lack of understanding of what the risks actually are," he said in a statement."Should it land in Australia, we might expect the same rush for souvenirs as we saw with Skylab, as anything that has been in space has a special meaning on Earth."?UARS was launched on 12 September 1991 and decommissioned on 15 December 2005. Its total dry mass is about 5.5 tonnes. UARS is one of the largest NASA satellites to plunge back to Earth uncontrolled in the last 30 years.Since the beginning of the Space Age in the late-1950s, there have been no confirmed reports of an injury resulting from re- entering space objects.? Nor is there a record of significant property damage resulting from a satellite re-entry.
SINGAPORE, Sept. 7 (Xinhua) -- Singapore scientists have found possible new ways to treat a type of aggressive breast cancer that is unresponsive to current forms of treatment, local broadcaster Channel NewsAsia reported on Wednesday.The team of scientists at the Genome Institute of Singapore ( GIS) and National University of Singapore (NUS), led by GIS senior group leader Qiang Yu, found that the enzyme EZH2 acts by inhibiting genes that stop the growth of tumors in the body.The insights could open the door to developing more effective treatment for fast spreading breast cancers, especially the estrogen receptor-negative breast cancer that is common all over the world.It was also found that through EZH2, cancer is promoted in the body by activating specific genes that impact breast cancer progression and cancer stem cell self-renewal.Yu said the new understanding on how EZH2 works as a cancer- causing gene in breast cancer has important therapeutic implication."The results suggest that small molecule drugs that block enzyme activity of EZH2 may not work for cancers caused by EZH2's activation genes," Yu said.Currently pharmaceutical companies have been developing drugs only to the block EZH2 enzyme activity so that tumor suppressers can perform their protective role in blocking cancer growth.Researchers said the next step would be to develop biomarkers to identify tumors with EZH2.This step would enable better treatment methods, with one of options being the development of therapies that shut down EZH2 completely and not just inhibit its enzymatic function.The findings have been published on the journal Molecular Cell.
BRUSSELS, May 31 (Xinhua) -- A deadly outbreak of E.coli linked to contaminated cucumbers is sending Europe on high alert, as death toll from the disease climbed to 16 till Tuesday.So far, 15 people have reportedly died and more than 300 were seriously ill from infections linked to tainted vegetables in Germany. Experts said the numbers are expected to increase in the coming week."We hope the number of cases will go down but we fear it will worsen," said Oliver Grieve, spokesperson with the University Medical Center Schleswig where most German victims are being treated.The German government has identified the pathogen as hemolytic-uremic syndrome (HUS), a serious complication of a type of E. coli known as Shiga toxin-producing E.coli (STEC). The bacteria could damage blood cells and kidneys, and hence cause deaths.A woman in her 50s was confirmed to be the first fatal victim out of Germany by a local hospital on Tuesday. Officials at the hospital in Boras, southwestern Sweden, said the woman, who had recently traveled to Germany, was admitted on May 29.Swedish health authorities already said on Sunday that 36 people, all linked to travel in northern Germany, had been confirmed to have infected with E.coli, whereas cases were also reported in France, the Netherlands, Denmark and Britain.It was the second food scare for European consumers this year. In January, highly toxic dioxin was found in eggs, poultry and pork products across Germany.
SAN FRANCISCO, Sept. 22 (Xinhua) -- Facebook on Thursday introduced a new feature called Open Graph, enabling users to access and share a wide range of media and lifestyle content on the social network site.According to Facebook's chief executive officer (CEO) Mark Zuckerberg, Open Graph lets users share what they are doing in Facebook-connected apps as they are doing it.These social apps focus on media apps including books, news, music, TV, movies and games, as well as lifestyle apps such as exercise, food, fashion and travel."The last five years of social networking have been about getting people signed up, and getting people connected with their lives. The next five years are going to be defined by the apps and depth of engagement," the young CEO said in a keynote speech at Facebook's f8 developer conference.Take music for example, Facebook integrates with European music streaming service Spotify. If one's Spotify account is connected to Facebook, a message will show up in the Ticker stating the song one is listening to and in the Timeline, a new design of one's profile page. The friends of the user can listen to the same song at the same time by hovering mouse over the song in Timeline or Ticker.Spotify founder and CEO Daniel Ek and movie streaming service Netflix CEO Reed Hastings also took stage as guest speakers to introduce their partnership with Facebook.Zuckerberg also introduced social news reading applications from major news organizations such as The Washington Post and Yahoo News, which allow users to access the content directly on Facebook.Earlier at the f8 conference, Timeline was unveiled as a new feature. It is a new profile design allowing users to scroll vertically through the big moments of one's life in a single page.Zuckerberg assured users that they have complete control over their Timeline, saying they can decide what content will appear and who can see it. The new feature will be available in a few weeks.Since Google launched its own social network "Google+" in June, Facebook has been in a combat mode, striving to roll out new products and features to beat the search giant. In his keynote speech on Thursday, Zuckerberg said half a billion people now use Facebook every day.Two days before the f8 conference, Google announced to open its social network to the public, noting it has introduced 100 new features in the three-month trial.