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SAN DIEGO (KGTV) — Researchers at the University of California, San Francisco are working on a spray designed to block the novel coronavirus from hijacking cells in the body, like a biological mask or internal personal protective equipment.They’re doing it by borrowing a defense mechanism from an unlikely source: llamas.The team, led by UCSF graduate student Michael Schoof, engineered a synthetic molecule based on one found in a llama’s immune system that acts like an antibody but is one-tenth the size.Human antibody treatments, known as convalescent plasma, require a transfusion in a hospital setting. But this smaller molecule, called a nanobody, can be easily self-administered via an inhaler or nasal spray and rapidly manufactured using yeast, Schoof said.The scientists named their product AeroNabs. They say it could be an inexpensive intervention for treating and preventing COVID-19 while the world waits for a vaccine.“We don't know how effective vaccines will be. We don't know how long it will take to rapidly deploy them, so we envision this product as hopefully a bridge until there is widespread, effective vaccination,” Schoof said.Once a vaccine is available, AeroNabs could offer protection for individuals who are unable to be inoculated for health reasons, he said, or an early treatment option.The team is in talks with commercial partners and hopes to begin clinical trials soon.In the 1980s, Belgian scientists discovered that about half of the antibodies in camels, llamas and alpacas are shaped differently than the antibodies found in other mammals, including humans. Researchers later learned they could use a fragment of these oddly shaped camelid antibodies to bind to antigens.Those fragments are called nanobodies.Currently, there is only one FDA-approved drug that uses nanobodies. Caplacizumab was approved last year to treat a rare blood disorder.The team at UCSF sifted through billions of nanobodies to find one that binded best to the spike proteins on the coronavirus, then engineered it to stick even better.The coronavirus uses its spikes to enter cells and replicate; the spikes are essentially the pathogen’s key into the body. By coating the spikes with nanobodies or antibodies, the viral key no longer fits into the body’s receptors and the virus can’t get in.“This works in the lab. It needs to be translated into the clinic,” said Schoof.The team at UCSF still needs to figure out the best delivery method, whether it is a nebulizer, an inhaler or a nasal spray. 2524
SAN DIEGO (KGTV) -- San Diego Police arrested nine people suspected of driving under the influence Saturday night. According to the department, the checkpoint was held on the 1400 block of G Street between 11:30 p.m. Saturday and 3 a.m. Sunday. A total of 2,403 vehicles went through the checkpoint, police say. More than 400 vehicles were screened, 13 drivers evaluated and nine people arrested on suspicion of driving under the influence of alcohol. San Diego Police said in a news release that they plan to conduct another DUI checkpoint at an undisclosed location on Halloween. The department also plans to increase patrol on Halloween to screen for intoxicated drivers. This week, companies like Uber are offering tips on how to get around for Halloween. Click here to check out the deal from Uber. There's also the option of taking public transportation to get around San Diego. Click here for information from San Diego's Metropolitan Transit System. 966

SAN DIEGO (KGTV) — San Diego is already known as "America's Finest City," but it's the region's craft beer heritage that fans say make it "America's Hoppiest City."San Diego's East Village will pay homage to the area's craft beer past, present, and future with the Museum of Beer (MoB), slated to be introduced in spring/summer 2020.MoB will highlight beer, beer history, and the brewing process through high-tech, immersive, and hands-on exhibits, according to the museum. Virtual reality-based exhibits will also walk guests through a brewhouse, beer festival, and bring them face-to-face with iconic, San Diego brewers.Guests will learn about how beer is made, styles of beer, and, of course, San Diego's place in craft beer history. Self-guided installations, educational sessions, and other beer-themed activities will be offered."San Diego is home to many of the world's finest craft breweries and the Museum of Beer will be the place to tap into all that our region's beer scene has to offer,” Mayor Kevin Faulconer said in a release. “It’s been a long time coming and I hope all beer lovers will visit the museum for a taste and experience of what's brewing right here in America’s Finest City."And what would a day learning about beer be without a beer? An on-site beer garden will help guests satisfy and expand their pallets, in addition to filling up at an artisan pizza kitchen and a tasting room featuring beers from San Diego Brewers Guild members.“We’ll also have a bottle list curated to showcase the best rare beers and limited releases from breweries around the county, along with a special barrel-aged component that will make the Museum of Beer’s food and drink venue unlike any other in San Diego," co-founder Mike Kociela, said in a release.Co-founder Anthony Ridenhour adds, "This kind of brick-and-mortar beer attraction will be a first for all of California ... it's going to be an Instagram playground and we can't wait to see how visitors explore the exhibits."To help fund the museum, an Indiegogo campaign has been started, featuring perks through the museum and its partners depending on donated amounts.The team behind the museum is hosting an open forum at 7 p.m. on April 15 at Amplified Ale Works in the East Village where guests can learn more about the museum, meet the curators, and ask questions. 2343
SAN DIEGO (KGTV) — San Diego officials are offering a new location to help temporarily shelter migrants seeking asylum.The city says it has identified a new property to use as a shelter since its current temporary shelter doesn't have the occupancy for long-term sheltering, in a letter to California's Office of Emergency Services."The county recently vacated the Camp Barrett youth correctional facility in Alpine. The facility is already classified for residential occupancy and therefore does not require significant alteration to be used as a shelter," Robert Vacchi, deputy chief operating officer of San Diego's Neighborhood Services, wrote.RELATED: Exclusive look inside San Diego shelter for migrant asylum seekersCamp Barrett was closed in October following years of steadily decreasing populations at the county's in-custody facilities, according to the county. The remaining population was relocated to a Urban Camp facility in Kearny Mesa. The facility was capable of housing 125 boys.Camp Barrett and surrounding property is owned by the city's Public Utilities Department, but slated for sale. Vacchi writes the property could be leased to the state or third-party on a temporary basis to use as a shelter for asylum-seeking migrants.The Alliance Healthcare Foundation has agreed to fund the operation of a facility, according to Vacchi, and the city has been in talks with the agency to secure shelter operations.The city is facing a Feb. 4 deadline to vacate the current shelter being used for migrant asylum seekers. The location of that shelter is being kept private to protect the migrants. 1618
SAN DIEGO (KGTV) - San Diego Police arrested Tuesday a man wanted on a warrant in Arizona after a short standoff in Golden Hill. Officers said someone called in an anonymous tip to report the 25-year-old man, wanted for a stabbing, was at the home at 3363 A St. When police went to the home, the man opened the door but shut it when he saw officers. Police called a SWAT team to the scene, and the San Diego Unified School District put nearby Golden Hill K-8 school on lockdown. The man surrendered after about one hour and the lockdown was lifted. Officers said a total of eight people were in the home at the time of the standoff.10News is monitoring developments in the story. 687
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