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SAN DIEGO (CNS) - Construction crews will close the northbound Interstate 5 off-ramp at Balboa Avenue Friday for a full weekend of work to make improvements to the off-ramp and its intersection with Balboa Avenue, according to the San Diego Association of Governments.The closure will take place from 9 p.m. Friday through 5 a.m. Monday, during which time construction crews will widen the off-ramp from one lane to two and add a traffic signal at the affected intersection. The signal will go into permanent operation on Monday when the ramp re-opens to vehicle traffic. The improvements will make it easier for motorists to access the future Balboa Avenue trolley station once it opens.The closure will necessitate lane reductions on Balboa and Garnet avenues between Mission Bay Drive and Moraga Avenue, according to SANDAG. Only one lane in each direction will be open to vehicle traffic throughout the weekend, although the schedule is subject to change.The weekend work is part of the .17 billion Mid-Coast Trolley Blue Line Extension, which includes a planned 11-mile extension of trolley service by MTS from Santa Fe Depot in downtown San Diego to University City. The extension will add trolley stops in Mission Bay Park, UC San Diego and Westfield UTC. SANDAG is receiving .04 billion in funding from the Federal Transit Administration to complete the project.The extension and related projects are intended to reduce traffic congestion as the county's population increases. Construction on the extension began in 2016 and is scheduled to be completed in 2021. 1582

SAN DIEGO (CNS) - Carlsbad-based Callaway Golf Co. announced Wednesday it has agreed to buy driving-range chain Topgolf Entertainment Group in an all-stock transaction valued at billion.The merger combines Callaway, a global golf equipment company, with Topgolf, which made its name as a party-golf attraction for players at all skill levels. Topgolf's driving ranges allow players to track their golf balls electronically and play against other groups nearby while ordering food and drinks.Callaway already owned 14 percent of Topgolf and first invested in the company in 2006."Together, Callaway and Topgolf create an unrivaled golf and entertainment business," said Chip Brewer, president and CEO of Callaway. "This combination unites proven leaders with a shared passion for delivering exceptional golf experiences for all -- from elite touring professionals to new and aspiring entrants to the game."Topgolf, founded in 2000, has 58 locations in North America.The company has 33 additional venues in some stage of planning nationwide, the San Diego Union-Tribune reported. In San Diego, the company has been talking with the Port of San Diego about building a 68,000 square foot facility on a seven-acre site along East Harbor Drive.Port commissioners are seeking additional financial information and have yet to enter into an exclusive negotiating agreement with Topgolf, according to the newspaper."As part of Callaway, we plan to grow our leadership position by leveraging Callaway's brand reputation, industry relationships and financial strength to connect more communities around the world to the Topgolf experience," said Dolf Berle, CEO of Topgolf.The merger is expected to be completed in early 2021, pending approval from both companys' shareholders. 1776

SAN DIEGO (CNS) - An international team of scientists, led by biologists at the University of California San Diego, has synthetically engineered mosquitoes that halt the transmission of the dengue virus, the university announced Thursday.Scientists at UC San Diego Associate Professor Omar Akbari's lab worked with Vanderbilt University Medical Center to identify a human antibody for dengue suppression. The broad-spectrum antibody stops the transmission of all four known types of the fever, compared to previous experiments, which have been able to limit single strains.The team then designed the antibody "cargo" to be synthetically expressed in the dengue-spreading Aedes aegypti mosquitoes.RELATED: UC San Diego study finds solutions for loneliness"Once the female mosquito takes in blood, the antibody is activated and expressed -- that's the trigger," Akbari said. "The antibody is able to hinder the replication of the virus and prevent its dissemination throughout the mosquito, which then prevents its transmission to humans. It's a powerful approach."Akbari works in the Division of Biological Sciences and is a member of the Tata Institute for Genetics and Society.These lab-engineers mosquitoes could be paired with a dissemination system, making it capable of spreading the antibody throughout wild disease- transmitting mosquitoes, Akbari said.Dengue fever is a virus that poses a severe risk to children and older adults in tropical regions in Asia and Latin America. There are an estimated 390 million infections every year, around 500,000 of which lead to Severe Dengue, and 25,000 people die of the disease every year.RELATED: UCSD Health, San Diego Zoo Safari Park team up to save gorilla's eyesightThe Pan American Health Organization recently reported the highest number of dengue cases ever recorded in the Americas. Infecting those with compromised immune systems, dengue victims suffer flu-like symptoms, including severe fevers and rashes. Serious cases can include life-threatening bleeding. No specific treatment exists and thus, prevention and control depend on measures that stop the spread of the virus.This development could go a long way toward limiting the disease's transmission."It is fascinating that we now can transfer genes from the human immune system to confer immunity to mosquitoes," said coauthor of the paper, Dr. James Crowe, Jr., director of the Vanderbilt Vaccine Center at Vanderbilt University Medical Center in Nashville, Tenn. "This work opens up a whole new field of biotechnology possibilities to interrupt mosquito-borne diseases of man."Akbari's lab is now in the early stages of testing methods to simultaneously neutralize mosquitoes against dengue and a suite of other viruses such as Zika, yellow fever and chikungunya. 2789

SAN DIEGO (CNS) - Another 2,925 of Pfizer's long-awaited COVID-19 vaccines arrived at UC San Diego Health for front line healthcare workers Tuesday morning.The vaccine -- estimated to be 95% effective at preventing COVID-19 -- recently received emergency use authorization from the U.S. Food and Drug Administration. Vaccine distribution is coordinated through the California Department of Public Health and public health departments, governed by recommendations from the U.S. Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices. Following these recommendations, health care workers are receiving the first available vaccinations."Our goal is to vaccinate as many employees as quickly as possible, depending upon supplies and evolving circumstances," said Patty Maysent, CEO of UC San Diego Health."With subsequent vaccine shipments from Pfizer and as other vaccines, such as Moderna, come online, we will expand the opportunity to vaccinate to all health system employees, our patients and communities beyond. We are determined to do this as safely and effectively, as rapidly and methodically, as we can," Maysent said. "But even with actual vaccinations starting, we must continue to follow all current measures designed to slow viral spread and infection, from masking and distancing to hand washing and signing up for CA NOTIFY."The first doses of the vaccine arrived Monday with San Diego County receiving and storing about 12,000 in subzero freezers to distribute to regional acute health care hospitals. Rady Children's Hospital will also receive vaccines this week.The 28,000 the county will receive in the first Pfizer batch is part of around 327,000 doses California is expected to receive in the first distribution. According to the county, the initial allotment will cover around 72% of what is needed for all identified health care first-tier recipients.Critical care health workers will be the first people to get the vaccine, followed by nursing home and long-term care facility residents and employees. The initial distribution will not be sufficient to vaccinate all people in those populations; however, the state anticipates receiving hundreds of thousand more doses over the next few weeks, followed by weekly allocations starting next year.Once people in these first two groups in are vaccinated and more COVID- 19 vaccine doses are available, they will go to essential workers such as people who work in education, food and agriculture, police officers, firefighters, correctional officers and transportation workers, among others.After that, the priority will be to vaccinate adults with underlying medical conditions and people over the age of 65 because they are at higher risk of developing serious complications from COVID-19.Naval Medical Center San Diego received an unspecified number of vaccines Monday, with front-line medical workers and essential mission personnel -- such as EMS, firefighters and security personnel -- to begin receiving the first dose of the vaccinations Tuesday. Naval Hospital Camp Pendleton took a portion of those doses for personnel north of San Diego and will begin vaccinations Wednesday.Rear Adm. Tim Weber, commander of Naval Medical Forces Pacific, said the number of doses delivered to the Navy in San Diego is likely fewer than the number of "first-tier" medical personnel at the two hospitals. Subsequent vaccine allotments -- as the supply chain dictates -- will allow for the second dose of the vaccine to be administered to medical and other mission-essential workers, as well as those who missed it the first time, Tricare dependents and non-essential personnel.The number of doses delivered to the San Diego-area military is classified, Weber said, calling it an "operational security issue." However, the U.S. government has allocated vaccines to 64 jurisdictions, and the DOD plans to administer its initial allocation of 43,875 doses to populations of uniformed service members -- both active and reserves. That includes members of the National Guard, dependents, retirees, civilian employees and select contract personnel.Capt. Devin Morrison, acting director of Naval Medical Center San Diego, said vaccines for military personnel will be voluntary until the FDA's emergency use authorization is lifted, at which time military personnel will follow DOD guidelines. Military personnel, including medical workers, can refuse the vaccine until then and will continue to operate with strict personal protective equipment standards, Morrison said. 4565

SAN DIEGO (CNS) - More than 28,000 defaulted bills were sent out to San Diego County taxpayers this week, but the county's treasurer announced Tuesday that his office is offering penalty relief."We know many of the late bills are due to COVID-19, and we want our taxpayers to know there could be relief," Treasurer-Tax Collector Dan McAllister said. "They may qualify to have their penalties waived if they file for a COVID-19 cancellation request. Our customers must provide documentation as evidence to show how the pandemic impacted their ability to pay their second installment by April 10."The 28,623 defaulted bills McAllister's office sent out went to property taxpayers who failed to pay all their 2019-20 property taxes."We're sending 6,195 more defaulted bills than we sent last year," he said. "We expected to see an increase in tax defaults due to COVID-19's impact on the San Diego economy and workforce."The defaulted bills total over 7 million; last year, million in defaulted taxes was due.The deadline to pay the 2019-20 annual tax bill was June 30. Beginning July 1, late bills will incur a 1.5% penalty each month -- 18% each year -- until they are paid. That is on top of the 10% penalty added for each late installment.Taxpayers who have submitted a COVID-19 penalty cancellation request and have not heard back from the Treasurer-Tax Collector yet will receive a response in the mail. The office has received 3,261 COVID-19 penalty cancellation requests and has approved 53% of them. Most denials are due to missing documentation, McAllister said. 1584

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